Vascular hyporesponsiveness of the renal circulation during endotoxemia in anesthetized pigs

Critical Care Medicine

Volumn 27, Issue 12, 1999, Pages 2735-2740

  Pastor, Catherine M ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Acetylcholine; Endotoxin; Norepinephrine; Pig; Renal circulation; Sepsis; Sodium nitroprusside; Vascular reactivity

Indexed keywords

CORTICOTROPIN; ENDOTOXIN; NITROPRUSSIDE SODIUM; NORADRENALIN;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; ENDOTOXEMIA; HYPOTENSION; KIDNEY CIRCULATION; KIDNEY PERFUSION; KIDNEY VASCULAR RESISTANCE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SWINE; VASOCONSTRICTION;

EID: 0033386916     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199912000-00022     Document Type: Article

References (46)

1. 1. Gullichsen E, Nelimarkka O, Halkola L, et al: Renal glucose and lactate metabolism in endotoxin shock in dogs. Acta Chir Scand 1989; 155:561-565
2. 2. Schaer GL, Fink MP, Chernow B, et al: Renal hemodynamics and prostaglandin E2 excretion in a nonhuman primate model of septic shock. Crit Care Med 1990; 18:52-59
3. 3. Weber A, Schweiger IA, Poinsot O, et al: Sequential changes in renal oxygen consumption and sodium transport during hyperdynamic sepsis in sheep. Am J Physiol 1992; 262:F965-F971
4. 4. O'Hair DP, Adams MB, Tunberg TC, et al: Relationships among endotoxemia, arterial pressure, and renal function in dogs. Circ Shock 1989; 27:199 -210
5. 5. Sibbald WJ, Fox G, Martin C: Abnormalities of vascular reactivity in the sepsis syndrome. Chest 1991; 100:155S-159S
6. 6. Julou-Schaeffer G, Gray GA, Fleming I, et al: Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway. Am J Physiol 1990; 259:H1038-H1043
7. 7. Bouvier C, Guc MO, Furman BL, et al: Platelet activating factor impairs pressor responses to noradrenaline in the anaesthetized rat but does not mediate endotoxin-induced hyporeactivity. Circ Shock 1994; 42:14-19
8. 8. Szabo C, Mitchell JA, Thiemermann C, et al: Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock. Br J Pharmacol 1993; 108:786-792
9. 9. Peters TS, Lewis SJ: Lipopolysaccharide inhibits acetylcholine-and nitric oxide-mediated vasodilation in vivo. J Pharmacol Exp Ther 1996; 279:918-925
10. 10. Lorente JA, Landin L, Renes E, et al: Role of nitric oxide in the hemodynamic changes of sepsis. Crit Care Med 1993; 21:759-767
11. 11. Wang P, Ba ZF, Chaudry IH: Endothelium-dependent relaxation is depressed at the macro-and microcirculatory levels during sepsis. Am J Physiol 1995; 269:R988-R994
12. 12. Wylam ME, Samsel RW, Umans JG, et al: Endotoxin in vivo impairs endothelium-dependent relaxation of canine arteries in vitro. Am Rev Respir Dis 1990; 142:1263-1267
13. 13. Wang P, Ba ZF, Chaudry IH: Nitric oxide: To block or enhance its production during sepsis? Arch Surg 1994; 129:1137-1143
14. 14. Breslow MJ, Miller CF, Parker SD, et al: Effect of vasopressors on organ blood flow during endotoxin shock in pigs. Am J Physiol 1987; 252:H291-H300
15. 15. Klemm P, Thiemermann C, Winklmaier G, et al: Effects of nitric oxide synthase inhibition combined with nitric oxide inhalation in a porcine model of endotoxin shock. Br J Pharmacol 1995; 114:363-368
16. 16. Astiz ME, Rackow EC, Falk JL, et al: Oxygen delivery and consumption in patients with hyperdynamic septic shock. Crit Care Med 1987; 15:26-28
17. 17. Shoemaker WC, Appel PL, Kram HG, et al: Temporal hemodynamic and oxygen transport patterns in medical patients: Septic shock. Chest 1993; 104:1529-1536
18. 18. Hom GJ, Grant SK, Wolfe G, et al: Lipopolysaccharide-induced hypotension and vascular hyporeactivity in the rat: Tissue analysis of nitric oxide synthase mRNA and protein expression in the presence and absence of dexamethasone, NG-monomethyl-L-arginine or indomethacin. J Phamacol Exp Ther 1995; 272:452-459
19. 19. Hauser GJ, Dayao EK, Zukowska-Grojec Z: Effect of neuropeptide Y on endotoxin-induced suppression of the response to various agonists in conscious rats. Life Sci 1995; 57:235-244
20. 20. Burnier M, Waeber B, Aubert JF, et al: Effects of nonhypotensive endotoxemia in conscious rats: Role of prostaglandins. Am J Physiol 1988; 254:H509-H516
21. 21. Stassen FR, Willemsen MJJMF, Janssen GMJ, et al: Reduced responsiveness of rat mesenteric resistance artery smooth muscle to phenylephrine and calcium following myocardial infarction. Br J Pharmacol 1997; 120: 1505-1512
22. 22. Sieber CC, Groszmann RJ: Nitric oxide mediates hyporeactivity to vasopressors in mesenteric vessels of portal hypertensive rats. Gastroenterology 1992; 103:235-239
23. 23. Heinemann A, Wachter CH, Holzer P, et al: Nitric oxide-dependent and -independent vascular hyporeactivity in mesenteric arteries of portal hypertensive rats. Br J Pharmacol 1997; 121:1031-1037
24. 24. Howard MG, DiCarlo SE: Reduced vascular responsiveness after a single bout of dynamic exercise in the conscious rabbit. J Appl Physiol 1992; 73:2662-2667
25. 25. Ryan AJ, Gisolfi CV: Responses of rat mesenteric arteries to norepinephrine during exposure to heat stress and acidosis. J Appl Physiol 1995; 78:38-45
26. 2 tensions. Am J Physiol 1990; 258:H1049-H1054
27. 27. McKenna TM: Recovery of vascular tissue contractile function during sustained endotoxin exposure. Am J Physiol 1992; 263: H1628-H1631
28. 28. McKenna TM: Prolonged exposure of rat aorta to low levels of endotoxin in vitro results in impaired contractility: Association with vascular cytokine release. J Clin Invest 1990; 86:160-168
29. 29. Li S, Fan SX, McKenna TM: Vascular smooth muscle cells on Matrigel as a model for LPS-induced hypocontractility and NO formation. Am J Physiol 1997; 272:H576-II584
30. 30. Lugon JR, Boim MA, Ramos OL, et al: Renal function and glomerular hemodynamics in male endotoxemic rats. Kidney Int 1989; 36: 570-575
31. 31. Kikeri D, Pennell JP, Hwang KH, et al: Endotoxemic acute renal failure in awake rats. Am J Physiol 1986; 250:F1098-F1106
32. 32. Badr KF, Kelley VE, Rennke HG, et al: Roles for thromboxane A2 and leukotrienes in endotoxin-induced acute renal failure. Kidney Int 1986; 30:474-480
33. 33. Cohen JJ, Black AJ, Wertheim SJ: Direct effects of endotoxin on the function of the isolated perfused rat kidney. Kidney Int 1990; 37:1219-1226
34. 34. Wang J, Dunn MJ: Platelet-activating factor mediates endotoxin-induced acute renal insufficiency in rats. Am J Physiol 1987; 253: F1283-F1289
35. 35. Spain DA, Wilson MA, Garrison RN: Nitric oxide synthase inhibition exacerbates sepsisinduced renal hypoperfusion. Surgery 1994; 116:322-330
36. 36. Bellomo R, Kellum JA, Pinsky MR: Transvisceral lactate fluxes during early endotoxemia. Chest 1996; 110:198-204
37. 37. Cai M, Sakamoto A, Ogawa R: Inhibition of nitric oxide formation with L-canavanine attenuates endotoxin-induced vascular hypore-activity in the rat. Eur J Pharmacol 1996; 295:215-220
38. 38. Landin L, Lorente JA, Renes E, et al: Inhibition of nitric oxide synthesis improves the vasoconstrictive effect of noradrenaline in sepsis. Chest 1994; 106:250-256
39. 39. Meyer J, Booke M, Waurick R, et al: Nitric oxide synthase inhibition restores vasopressor effects of norepinephrine in ovine hyperdynamic sepsis. Anesth Analg 1996; 83:1009-1013
40. 40. Bhagat K, Collier J, Vallance P: Local venous responses to endotoxin in humans. Circulation 1996; 94:490-497
41. 41. Page IH, Olmsted F: The influence of respiratory gas mixtures on arterial pressure and vascular reactivity in "normal" and hypertensive dogs. Circulation 1951; 3:801-819
42. 42. Evans T, Carpenter A, Kinderman H, et al: Evidence of increased nitric oxide production in patients with the sepsis syndrome. Circ Shock 1993; 41:77-81
43. 43. Ochoa JB, Udekwu AO, Billiar TR, et al: Nitrogen oxide levels in patients after trauma and during sepsis. Ann Surg 1991; 214:621-626
44. 44. Groves AC, Griffiths J, Leung F, et al: Plasma catecholamines in patients with serious post-operative infection. Ann Surg 1973; 178: 102-107
45. 45. Hofford JM, Milakofsky L, Pell S, et al: A profile of amino acid and catecholamine levels during endotoxin-induced acute lung injury in sheep: Searching for potential markers of the acute respiratory distress syndrome. J Lab Clin Med 1996; 128: 545-551
46. 46. Pastor CM, Billiar TR: Nitric oxide causes hyporeactivity to phenylephrine in isolated perfused livers from endotoxin-treated rats. Am J Physiol 1995; 268:G177-G182