Rectal bioavailability of ibuprofen from hard gelatin capsules containing sodium phosphates as adjuvants and soft gelatin capsules or suppositories as references

S.T.P. Pharma Sciences

Volumn 9, Issue 6, 1999, Pages 579-585

  Leino, J ^a   Salmela, O ^a   Alastalo, H ^a   Eerikainen S ^b   Klinge, E ^a   Marvola, M ^a  

^a Department of Pharmacy ^*  (Finland)

^b University of Pharmacy   (Finland)

Author keywords

Bioavailability; Bioequivalence; Coating agent; Disodium hydrogen phosphate; Hard gelatin capsule; Ibuprofen; Rectal administration; Sodium dihydrogen phosphate; Soft gelatin capsule; Suppository

Indexed keywords

GELATIN; IBUPROFEN; SODIUM DIHYDROGEN PHOSPHATE;

ARTICLE; BIOEQUIVALENCE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CAPSULE; DRUG SOLUBILITY; PH; RECTUM; SUPPOSITORY;

EID: 0033386175     PISSN: 11571489     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. EERIKÄINEN S., LEINO J., HARJULA M., KLINGE E. and MARVOLA M. - Use of hard gelatin capsules as rectal dosage forms. - STP Pharm.Sci., 6, 435-440, 1996.
2. LEINO J., HAAVISTO H., TOMMINEN T., HEINILÄ K., EERIKÄINEN S., KLINGE E. and MARVOLA M. - Development of rectally administered prolonged-release hard gelatin capsules using different polymers as diluents. - STP Pharm. Sci., 7, 348-353, 1997.
3. DE BOER A., VAN HOOGDALEM E., HEIJLIGERS-FEIJEN C., VERHOEF J. and BREIMER D. - Rectal absorption enhancement of peptide drugs. - J.Contr.Rel., 13, 241-246, 1990.
4. NEWTON J. - Drug release from capsules. - In: Hard Capsules, Development and Technology, Paperbook, The Pharmaceutical Press, London), 1987, pp. 195-204.
5. MOOLENAAR F., OLTHOF L. and HUIZINGA T. -Biopharmaceutics of rectal administration of drugs in man. 3. Absorption rate and bioavailability of paracetamol from rectal aqueous suspensions. - Pharm. Weekbl. Sci. Ed., 1, 201-206, 1979.
6. TAKUBO T., MATSUMARU H., TSUCHIYA S. and HIURA M. - Studies on absorption of suppositories. IV. Effect of buffer reagents on absorption of sulfonamides. - Chem.Pharm.Bull., 21, 1440-1445, 1973.
7. MOOLENAAR F., PRONK J., VISSER J. and MEIJER D. -Rectal versus oral absorption of diflunisal in man. - Int. J. Pharm., 19, 161-167, 1984.
8. MOOLENAAR F., YSKA J., VISSER J. and MEIJER D. - Drastic improvement in the rectal absorption profile of morphine in man. - Eur. J. Clin. Pharmacol., 29, 119-121, 1985.
9. MOOLENAAR F., GRASMEIJER G., VISSER J. and MEIJER D. - Rectal versus oral absorption of codeine phosphate in man. - Biopharm. Drug Disp., 4, 195-199, 1983.
10. HERMAN T. - Recent research on unavailability of drugs from suppositories. - Int. J. Pharm., 123, 1-11, 1995.
11. AVGERINOS A. and HUTT A. - High-performance liquid chromatographic determination of ibuprofen in human plasma and urine by direct injection. - J.Chromatogr., 380, 468-471, 1986.
12. SHAH V., MIDHA K., DIGHE S, McGIVERAY I., SKELLY J., YACOBI A., LAYLOFF T., VISWANATHAN C., COOK C., McDOWALL R., PITTMAN K and SPECTOR S. - Analytical methods validation: Bioavailability, bioequivalence and pharmacokinetic studies. - J. Pharm. Sci., 81, 309-312, 1992.
13. NÄRVÄNEN T., HALSAS M., SMAL J. and MARVOLA M. - Is one paracetamol suppository of 1000 mg bioequivalent with two suppositories of 500 mg? - Eur.J.Drug Metabol.Pharmacokin., 23, 203-206, 1998.