Use of a hard gelatin capsule as a rectal dosage form

S.T.P. Pharma Sciences

Volumn 6, Issue 6, 1996, Pages 435-440

  Eerikainen S ^a   Leino, J ^b   Harjula, M ^b   Klinge, E ^b   Marvola, M ^b  

^a University Pharmacy   (Finland)

^b Department of Pharmacy ^*  (Finland)

Author keywords

Bioavailability; Diluent; Hard gelatin capsule; Hydroxypropylmethyl cellulose; Ibuprofen; Rectal administration

Indexed keywords

CALCIUM PHOSPHATE DIBASIC; EXCIPIENT; GELATIN; HYDROXYPROPYLMETHYLCELLULOSE; IBUPROFEN; LACTOSE;

ADULT; ARTICLE; BIOAVAILABILITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG SOLUBILITY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PHARMACOKINETICS; RANDOMIZED CONTROLLED TRIAL; RECTAL DRUG ADMINISTRATION;

EID: 0029847540     PISSN: 11571489     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. STOREY P. and TRUMBLE M. - Rectal doxepin and carbamazepine therapy in patients with cancer. - N. Engl. J. Med., 327, 1318-1319, 1992.
2. ISHIKAWA M., YOKOTA N., SAWAZAKI A., KASHIRO S., HIRATA S., OKADA M. and ISHIKAWA K. - Rectal administration of perforated nifedipine capsules to maintain an effective level of longer duration. - Am. Heart J., 11, 1116-1119, 1986.
3. UCHIYAMA M. and OGAWA T. - Rectal nifedipine in acute severe hypertension in young children (a letter). - Arch. Dis. Child, 64, 632-633, 1989.
4. UCHIYAMA M. and SAKAI K. - Rectal administration of perforated nifedipine capsules in acute severe hypertension in children. - Br. J. Clin Pract., 46, 100-101, 1992.
5. HANNULA A.-M., HAGENLOCHER M. and SPEISER P. -Evaluation of a gliding coat for rectal hard gelatin capsules. -Acta Pharm. Technol., 32, 26-28, 1986.
6. VAN HOOGDALEM E., DE BOER A.G. and BREIMER D.D. -Pharmacokinetics of rectal drug administration, part II. Clinical applications of peripherally acting drugs, and conclusions. -Clin. Pharmacokinet., 21, 110-128, 1991.
7. AVREGINOS A. and HUTT A.J. - High-performance liquid chromatographic determination of ibuprofen in human plasma and urine by direct injection. - J. Chromatogr., 380, 468-471, 1986.
8. SHAH V.P., MIDHA K.K., DIGHE S., McGIVERAY I J., SKELLY J.P., YACOBI A., LAYLOFF T., VISWANATHAN C.T., COOK C.E., McDOWALL R.D., PITTMAN K.A. and SPECTOR S -Analytical methods validation : bioavailability, bioequivalence and pharmacokinetic studies. - J. Pharm. Sci., 81, 309-312, 1992.
9. OJANTAKANEN S., HANNULA A.-M. and MARVOLA M -Bioavailability of ibuprofen from hard gelatin capsules containing sodium bicarbonate, lactose or dicalcium phosphate. - Acta Pharm. Fenn., 99, 119-126, 1990.
10. EERIKAINEN S., FORSSELL K. and MARVOLA M - The bioavailability of ibuprofen from two different kinds of mixture compared with a rectal preparation for pediatric treatment. -54th International Congress of FIP, Lisbon, 4-9 September, 1994, ABGI, p.142.