Role of glutathione in the detoxication by metallothionein of hepatic copper

Pharmacometrics

Volumn 58, Issue 1, 1999, Pages 23-30

  Kato, Naoyuki ^a   Nakai, Shuzo ^b  

^a TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHO UNIVERSITY   (Japan)

Author keywords

Copper; Detoxication; Glutathione; Metallothionein; Rat liver

Indexed keywords

COPPER; COPPER SULFATE; CYCLOHEXIMIDE; GLUTATHIONE PEROXIDASE; GLYOXALASE; LEAD; MALEIC ACID DIETHYL ESTER; MERCURY; METALLOTHIONEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATOMIC EMISSION SPECTROMETRY; CONCENTRATION RESPONSE; DETOXIFICATION; DOSE LIVER FUNCTION RELATION; DOSE TIME EFFECT RELATION; DRUG LIVER LEVEL; GLUTATHIONE METABOLISM; LIVER METABOLISM; MALE; NONHUMAN; PROTEIN SYNTHESIS INHIBITION; RAT;

EID: 0033380840     PISSN: 03008533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Akerboom, T.P.M and Sies, H. (1981): Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples. Methods in Enzymology, Academic Press, Inc., New York, 77, 373-382.
2. Barnhart, J.L. and Combes, B. (1978): Choleresis associated with metabolism and biliary excretion of diethyl maleate in the rat and dog, J. Phamacol. Exp. Ther, 206, 614-623.
3. Bernt, E. and Bergmeyer, H.U. (1974): in Methods of Enzymatic Analysis (ed. Bergmeyer, H.U.), Verlag Chemie, Weinheim, pp. 1643-1647.
4. Boyland, E. and Chasseaud, L.F. (1970): The effect of some carboxyl compounds on rat liver glutathione levels, Biochem. pharmacol, 19, 1526-1528.
5. Britton, R. (1996): Metal-induced hepatotoxicity, Seminars in liver disease, 16, 3-12.
6. Cherian, M.G. and Goyer, R.A. (1978): Role of metallothioneins in disease. Ann. Clin. Lab. Sci., 8, 91-94.
7. Christie, N.T and Costa, M. (1984): In vitro assessment of the toxixity of metal compounds. Biol. Trace Element Res., 6, 139-158.
8. Ferreira, A M.D.C., Ciriolo, M.R., Marcocci, L. and Rotilio, G. (1993): Copper (I) transfer into metallothionein mediated by glutathione, Biochem. J., 292, 673-676.
9. Freedman, J.H., Ciriolo, MR. and Peisach, J. (1989). The role of glutathione in copper metabolism and toxicity, J. Biol. Chem., 264, 5598-5605.
10. Garcia-Ruiz, C., Fernandez-Checa, J.C. and Kaplowitz, N. (1995): Bidrectional mechanism of plasma membrane transport of reduced glutathione in intact rat hepatocytes and membrane vesicles, J. Biol. Chem., 267, 22256-22264.
11. Higashi, T., Furukawa, M., Hikita, K., Naruse, A., Tateishi, N. and Sakamoto, Y. (1985): Reevaluation of protein-bound glutathione in rat liver, J. Biochem., 98, 1661-1667.
12. Irato, P., Sturniolo, G.C., Giacon, G., Magro, A., D'Inca, R., Mestriner, C. and Albergoni, V. (1996): Effect of zinc supplementation on metallothionein, copper, and zinc concentration in various tissues of copper-loaded rats, Biol. Trace Element Res., 51, 87-95.
13. Kagi, J.H.R. (1993): Evolution, sturucture and chemical activity of class I metallothioneins: an overview In: Suzuki, K T., Imura, N. and Kimura, M. (eds), Metallothionein III, Basel, Switzerland, Birkhauser Verlag, pp. 29-56.
14. Kosower, N S. and Kosower, E.M. (1978): The glutathione status of cells, Int. Rev. Cytol., 54, 109-160.
15. Kotsonis, F.N. and Klaassen, C.D. (1979): Increase in hepatic metallothionein in rats treated with alkylating agents, Toxicol. Appl. Pharmacol., 51, 19-27.
16. Meredith, M.J and Reed, D J. (1982): Status of the mitochondrial pool of glutathione in the isolated hepatocyte, J. Biol. Chem., 257, 3747-3753.
17. Nakayama, K., Okabe, M., Aoyagi, K., Yamanoshita, O., Okui, T., Ohyama, T. and Kasai, N. (1996): Visualization of yellowish-orange luminescence from cuprous metallothioneins in liver of Long-Evans Cinnamon rat, Biochim. Biophys. Acta, 1289, 150-158.
18. Okayasu, T., Tochimaru, H., Hyuga, T, Takahashi, T., Takekoshi, Y., Li, Y., Togashi, Y., Takeichi, N., Kasai, N. and Arashima, S. (1992): Inherited copper toxicity in Long-Evans Cinnamon rats exhibiting spontaneous hepatitis, Pediatric Res., 31, 253-257.
19. Rafter, G.W (1982): The effect of copper on glutathione metabolism in human leukocytes, Biol. Trace Element Res., 4, 191-197
20. Reed, D.J. and Fariss, M.W. (1984): Glutathione depletion and susceptibility, Pharmacol. Rev., 36, 25S-33S.
21. Reed, D.J. (1990): Glutathione, Annu. Rev. Pharmacol. Toxicol., 30, 603-631.
22. Saito, S. and Kojima, Y. (1997): Differential role of metallothionem on Zn, Cd and Cu accumulation in hepatic cytosol of rats, Cell. Mol. Life Sci., 53, 267-270.
23. Sakurai, H., Fukudome, A., Tawa, R., Kito, M., Takeshima, S., Kimura, M., Otaki, M., Nakajima, K., Hagino, T., Kawano, K , Hirai, S. and Suzuki, S. (1992a): Unusual accumulation of copper related to induction of metallothionein in the liver of LEC rats, Biochem. Biophys. Res. Commun., 184, 1393-1397.
24. Sakurai, H., Kamada, H., Fukudome, A., Kito, M., Takeshima, S., Kimura, M., Otaki, N., Nakajima, K., Kawano, K. and Hagino, T (1992b): Copper-metallothionein induction in the liver of LEC rats, Biochem. Biophys. Res. Commun., 185, 548-552.
25. Sakurai, H., Satoh, H., Hatanaka, A., Sawada, T., Kawano, K., Hagino, T. and Nakajima, K. (1994): Unusual generation of hydroxyl radicals in hepatic copper-metallothionein of LEC (Long-Evans Cinnamon) rats in the presence of hydrogen peroxide, Biochem. Biophys. Res. Commun., 199, 313-318.
26. Sasaki, M., Yoshida, M.C., Kagami, K., Kobayashi, H., Dempo, K. and Mori, M. (1985): Spontaneous hepatitis in an inherited strain of Long-Evans rats, Rat News Lett., 14, 4-6.
27. Satoh, M, Naganuma, A. and Imura, N. (1992): Effect of preinduction of metallothionein on paraquat toxicity in mice, Arch. Toxicol., 66, 145-148.
28. Scheuhammer, A.M and Cherian, M.G. (1986). Quantification of metallothioneins by a silver-saturation method, Toxicol. Appl. Pharmacol., 82, 417-425.
29. Scheuhammer, A.M. and Cherian, M.G. (1991): Quantification of metallothionein by silver saturation, Methods Enzymol., 205, 78-83.
30. Schnellmann, R.G., Gilchrist, S.M. and Mandel, L.J. (1988): Intracellular distribution and depletion of glutathione in rabbit renal proximal tubules, Kidney Int., 34, 229-233
31. Shan, X., Jones, D.P., Hashmi, M. and Anders, M.W. (1993): Selective depletion of mitochondrial glutathione concentrations by (R,S)-3-hydroxy-4-pentenoate potentiates oxidative cell death, Chem. Res. Toxicol., 6, 75-81.
32. Smith, R.C., Reed, V.D. and Hill, W.E. (1994): Oxidation of thiols by copper (II), Phos. Sulf. Silicon, 90, 147-154.
33. Takeichi, N , Kobayashi, H., Yoshida, MC., Sasaki, M., Dempo, K. and Mori, M. (1988): Spontaneous hepatitis in Long-Evans rats: a potential animal model for fulminant hepatitis in man, Acta Pathol. Jpn., 38, 1369-1375.
34. Tietze, F. (1969): Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione, Anal. Biochem., 27, 502-522.
35. Thornalley, P.J. and Vasak, M. (1985): Possible role for metallothionein in protection against radiation-induced oxidative stress, Biochim. Biophys. Acta, 827, 36-44.
36. Yamada, T., Suzuki, Y., Agui, T. and Matsumoto, K. (1992): Elevation of metallothionein gene expression associated with hepatic copper accumulation in Long-Evans Cinnamon mutant rat, Biochim. Biophys. Acta, 1131, 188-191
37. Yoshida, H., Kuronuma, Y., Iijima, M., Tamano, T. and Harada, T. (1993): Effects of glutathione isopropyl ester on bile flow in glutathione-depleted rats, Arch. Int. Pharmacodyn., 322, 105-114.