Analysis of β-tubulin cDNAs from taxol-resistant Pestalotiopsis microspora and taxol-sensitive Pythium ultimum and comparison of the taxol-binding properties of their products

Molecular and General Genetics

Volumn 262, Issue 4-5, 1999, Pages 857-868

  Mu, J H ^a   Bollon, A P ^a   Sidhu, R S ^a  

^a Cytoclonal Pharmaceutics Inc   (United States)

Author keywords

tubulin; Achlya klebsiana; Pestalotiopsis microspora; Pythium ultimum; Taxol

Indexed keywords

ANTINEOPLASTIC AGENT; ASPARAGINE; BETA TUBULIN; COMPLEMENTARY DNA; GLUTAMINE; PACLITAXEL; THREONINE; TIABENDAZOLE; TRITIUM;

AMINO ACID SEQUENCE; ARTICLE; ASCOMYCETES; CELL CYCLE; COMPARATIVE STUDY; DEPOLYMERIZATION; DRUG BINDING SITE; DRUG RESISTANCE; DRUG SENSITIVITY; MICROTUBULE; NONHUMAN; NUCLEOTIDE SEQUENCE; OOMYCETES; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; DNA, COMPLEMENTARY; HUMANS; MITOSPORIC FUNGI; MOLECULAR SEQUENCE DATA; PACLITAXEL; PROTEIN BINDING; PYTHIUM; RADIOLIGAND ASSAY; RNA, FUNGAL; SEQUENCE HOMOLOGY, AMINO ACID; TRITIUM; TUBULIN;

ACHLYA KLEBSIANA; ANIMALIA; ASCOMYCOTA; FUNGI; MYXOGASTRIA; OOMYCETES; PESTALOTIOPSIS MICROSPORA; PYTHIUM ULTIMUM; TRITIUM;

EID: 0033376338     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380051151     Document Type: Article

References (50)

1. Barnes G, Louie KA, Botstein D (1992) Yeast proteins associated with microtubules in vitro and in vivo. Mol Biol Cell 3:29-47
2. Baum SG, Wittner M, Nadler JP, Horwitz SB, Dennis JE, Schiff PB, Tanowitz HB (1981) Taxol, a microtubule stabilizing agent, blocks the replication of Trypanosoma cruzi. Proc Natl Acad Sci USA 78:4571-4575
3. Cameron LE, Hutsul J-A, Thorlacius L, Lejohn HB (1990) Cloning and analysis of β-tubulin gene from a protoctist. J Biol Chem 265:15245-15252
4. Davidse LC, Flach W (1977) Differential binding of methyl benzimidazole-2-yl-carbamate to fungal tubulin as a mechanism of resistance to this antimitotic agent in mutant strains of Aspergillus nidulans. J Cell Biol 72:174-193
5. Davidse LC, Flach W (1978) Interaction of thiabendazole with fungal tubulin. Biochim Biophys Acta 543:82-90
6. Duerr A, Pallas D, Solomon F (1981) Molecular analysis of cytoplasmic microtubules in situ: identification of both widespread and specific proteins. Cell 24:203-211
7. Farr GW, Sternlicht H (1992) Site-directed mutagenesis of the GTP-binding domain of β-tubulin. J Mol Biol 227:307-321
8. Fugimura M, Oeda K, Inoue H, Kato T (1992) A single amino-acid substitution in the beta-tubulin gene of Neurospora confers both cabendazim resistance and diethofencarb sensitivity. Curr Genet 21:399-404
9. Giannakakou P, Sackett DL, Kang Y-K, Zhan Z, Buters JTM, Fojo T, Poruchynsky MS (1997) Paclitaxel-resistant human ovarian cancer cells have mutant β-tubulins that exhibit impaired paclitaxel-driven polymerization. J Biol Chem 272:17118-17125
10. Goldman GH, Temmerman W, Jacobs D, Contreras R, Van Montagu M, Herrera-Estrella A (1993) A nucleotide substitution in one of the β-tubulin genes of Trichoderma viride confers resistance to the antimitotic drug methyl benzimidazole-2-yl-carbamate. Mol Gen Genet 240:73-80
11. Hiraoka Y, Toda T, Yanagida M (1984) The NDA3 gene of fission yeast encodes β-tubulin: a cold-sensitive nda3 mutation reversibly blocks spindle formation and chromosome movement in mitosis. Cell 39:349-358
12. Horwitz SB (1992) Mechanism of action of taxol. Trends Pharmacol Sci 13:134-136
13. Jachez B, Nordmann R, Loor F (1993) Restoration of taxol sensitivity of multidrug-resistant cells by the cyclosporine SDZ PSC 833 and the cyclopeptide SDZ 280-446. J Natl Cancer Inst 85:478-483
14. Jung MK, Oakley BR (1990) Identification of an amino acid substitution in the benA, β-tubulin gene of Aspergillus nidulans that confers thiabendazole resistance and benomyl supersensitivity. Cell Motil Cytoskeleton 17:87-94
15. Jung MK, Wilder IB, Oakley BR (1992) Amino acid alterations in the benA (β-tubulin) gene of Aspergillus nidulans that confer benomyl resistance. Cell Motil Cytoskeleton 22:170-174
16. Kellogg DR, Field CM, Alberts BM (1989) Proteins in the centrosome, spindle, and kinetochore of the early Drosophila embryo. J Cell Biol 109:2977-2991
17. Kilmartin JV (1981) Purification of yeast tubulin by self-assembly in vitro. Biochemistry 20:3629-3633
18. Li J-Y, Strobel G, Sidhu R, Hess WM, Ford EJ (1996) Endophytic taxol-producing fungi from bald cypress, Taxodium distichum. Microbiology 142:223-226
19. Li J-Y, Sidhu RS, Bollon A, Strobel GA (1998a) Stimulation of taxol production in liquid culture of Pestalotiopsis microspora. Mycol Res 102:461-464
20. Li J-Y, Sidhu RS, Ford EJ, Long DM, Hess WM, Strobel GA (1998b) The induction of taxol production in the endophytic fungus Periconia sp from Torreya grandifolia. J Ind Microbiol Biotechnol 20:259-264
21. Linse K, Mandelkow E-M (1988) The GTP-binding peptide of β-tubulin: localization by direct photoaffinity labeling and comparison with nucleotide-binding proteins. J Biol Chem 263:15205-15210
22. Littauer UZ, Giveon D, Thierauf M, Ginzburg I, Ponstingl H (1986) Common and distinct tubulin binding sites for microtubule-associated proteins. Proc Natl Acad Sci USA 83:7162-7166
23. Manfredi JJ, Parness J, Horwitz SB (1982) Taxol binds to cellular microtubules. J Cell Biol 94:688-696
24. Manfredi JJ, Horwitz SB (1984) Taxol: an antimitotic agent with a new mechanism of action. Pharmacol Ther 25:83-125
25. Margulis L, Corliss JO, Melkonian M, Chapman DJ (eds) (1990) Handbook of Protoctisca. Jones and Bartlett, Boston
26. May GS, Tsang ML-S, Smith H, Fidel S, Morris NR (1987) Aspergillus nidulans β-tubulin genes are usually divergent. Gene 55:231-243
27. Neff NF, Thomas JH, Grisafi P, Botstein D (1983) Isolation of the β-tubulin gene from yeast and demonstration of its essential function in vivo. Cell 33:211-219
28. Nogales E, Wolf SG, Downing KH (1998) Structure of the αβ tubulin dimer by electron crystallography. Nature 391:199-203
29. Nogales E, Whittaker M, Milligan RA, Downing KH (1999) High-resolution model of he microtubule. Cell 95:79-88
30. Oakley BR (1994) Gamma-tubulin. In: Hyams JS, Lloyd CW (eds) Microtubules. Wiley-Liss, New York, pp 38-45
31. Orbach MJ, Porro EB, Yanofsky C (1986) Cloning and characterization of the gene for β-tubulin from a benomyl-resistant mutant of Neurospora crassa and its use as a dominant selectable marker. Mol Cell Biol 6:2452-2461
32. Panaccione DG, McKiernan M, Hanau RM (1988) Colletotrichum graminicola transformed with homologous and heterologous benomyl-resistance genes retains expected pathogenicity to corn. Mol Plant Microbe Interact 1:113-120
33. Parness J, Horwitz SB (1981) Taxol binds to polymerized tubulin in vitro. J Cell Biol 91:479-487
34. Proudfoot NJ, Brownlee GG (1976) 3′ Non-coding region sequences in eukaryotic messenger RNA. Nature 263:211-214
35. Rao S, Krauss NE, Heerding JM, Swindell CS, Ringel I, Orr GA, Horwitz SB (1994) 3′-(p-Azidobenzamido) taxol photolabels the N-terminal 31 amino acids of β-tubulin. J Biol Chem 269:3132-3134
36. Rao S, Orr GA, Chaudhary AG, Kingston DGI, Horwitz SB (1995) Characterization of the taxol binding site on the microtubule. J Biol Chem 270:20235-20238
37. Rowinsky EK, Donehower RC (1991) The clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeutics. Pharmacol Ther 52:35-84
38. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
39. Schiff PB, Fant J, Horwitz SB (1979) Promotion of microtubule assembly in vitro by taxol. Nature 277:665-667
40. Schliwa M, van Blerkom J, Porter KR (1981) Stabilization of the cytoplasmic ground substance in detergent-opened cells and a structural and biochemical analysis of its composition. Proc Natl Acad Sci USA 78:4329-4333
41. Stierle A, Strobel G, Stierle D (1993) Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew. Science 260:214-216
42. Strobel GA, Hess WM, Ford E, Sidhu RS, Yang X (1996a) Taxol from fungal endophytes and the issue of biodiversity. J Ind Microbiol 17:417-423
43. Strobel G, Yang X, Sears J, Kramer R, Sidhu RS, Hess WM (1996b) Taxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallachiana. Microbiology 142:435-440
44. Sullivan KF (1988) Structure and utilization of tubulin isotypes. Ann Rev Cell Biol 4:687-716
45. Thomas JH, Neff NF, Botstein D (1985) Isolation and characterization of mutations in the β-tubulin gene of Saccharomyces cerevisiae. Genetics 112:715-734
46. Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT (1971) Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc 93:2325-2327
47. Weerakoon ND, Roberts JK, Lehnen LPJr, Wilkinson JM, Marshall JS, Hardham AR (1998) Isolation and characterization of the single beta-tubulin gene in Phytophthora cinnamomi. Mycologia 90:85-95
48. Yen TJ, Machlin PS, Cleveland DW (1988) Autoregulated instability of β-tubulin mRNAs by recognition of the nascent amino terminus of β-tubulin. Nature 334:580-585
49. Yoon Y, Oakley BR (1995) Purification and characterization of assembly-competent tubulin from Aspergillus nidulans. Biochemistry 34:6373-6381
50. Young DH, Michelotti EL, Swindell CS, Krauss NE (1992) Antifungal properties of taxol and various analogues. Experientia 48:882-885