Endothelial no release caused by red wine polyphenols

Journal of Physiology and Pharmacology

Volumn 50, Issue 4, 1999, Pages 535-540

  Stoclet, J C ^a   Kleschyov, A ^a   Andriambeloson, E ^a   Diebolt, M ^a   Andriantsitohaina, R ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Cardiovascular protection; Endothelium; Intracellular Ca2+; Nitric oxide; Polyphenols; Red wine

Indexed keywords

ANTHOCYANIN; BRADYKININ; CALCIUM ION; CARBACHOL; CATECHIN; CYANIDIN 3 GLUCOSIDE; DELPHINIDIN; EPICATECHIN; MALVIDIN CHLORIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NORADRENALIN; POLYPHENOL DERIVATIVE; QUERCETIN;

ANIMAL CELL; ANIMAL TISSUE; CALCIUM CELL LEVEL; CARDIOVASCULAR DISEASE; CONFERENCE PAPER; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; ENDOTHELIUM CELL; EXTRACELLULAR CALCIUM; HEART PROTECTION; MALE; NONHUMAN; RAT; SMOOTH MUSCLE FIBER; VASODILATATION; WINE;

ANIMALS; AORTA; BRADYKININ; CALCIUM; CARBACHOL; ENDOTHELIUM, VASCULAR; FLAVONOIDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NOREPINEPHRINE; PHENOLS; POLYMERS; RATS; RATS, WISTAR; WINE;

EID: 0033372509     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (15)

1. Fitzpatrick D, Hirschfield SL, Coffey RG. Endothelium-dependent vasorelaxing activity of wine and other grape products. Am J Physiol 1993; 265:H774-H778.
2. Fitzpatrick D, Hirschfeld SL, Ricci T, Jantzen P, Coffey RG. Endothelium-dependent vasorelaxation caused by various plant extracts. J Cardiovasc Pharmacol 1995; 26:90-95.
3. Andriambeloson E., Kleschyov AL, Muller B, Beretz A, Stoclet JC, Andriatsitohaina R. Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat aorta. Br J Pharmacol 1997; 120:1053-1058.
4. Andriambeloson E, Stoclet JC, Andriantsitohaina R. Mechanism of endothelial nitric oxide-dependent vasorelaxation induced by wine polyphenols in rat thoracic aorta. J Cardiovasc Pharmacol 1999; 33:248-254.
5. Renaud S, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart diesease. Lancet 1992; 339:1523-1526.
6. Goldberg DM, Hahn SE, Parkes JG. Beyond alcohol: beverage consumption and cardiovascular mortality. Clin Chem Acta 1995; 237:155-187.
7. Gronbeck M, Deis A, Sorensen TA, Becker U, Schnohr P, Jensen G. Mortality associated with moderate intakes of wine, beer or spirits. Brit Med J 1995; 310:1165-1169.
8. Renaud SC, Guéguen R, Schenker J, D'Houtaud A. Alcohol and mortality in middle-aged men from eastern France. Epidemiology 1998; 9:184-188.
9. Andriambeloson E, Magnier C, Haan-Archipoff G, Lobstein A, Anton R, Beretz A, Stoclet JC, Andriantsitohaina R. Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta. J Nutr 1998; 128:2324-2333.
10. Wollny T, Aiello L, Di Tommaso D, Bellavia V, Rotilio D, Donati MB, de Gaetano G, Iacoviello L. Modulation of haemostatic function and prevention of experimental thrombosis by red wine in rats: a role for increased nitric oxide production. Br J Pharmacol 1999; 127:747-755.
11. Andriantsitohaina R, Andriambeloson E, Stoclet JC. Pharmacological approaches of endothelial nitric oxide dependent vasorelaxation induced by polyphenols from plant extracts. Meth Enzymol 1999; 301:522-532.
12. Andriambeloson E, Duarte J, Kleschyov A, Stoclet JC, Andriantsitohaina R. Mechanism of nitric oxide production by wine polyphenols in bovine aortic endothelial cells. J Vasc Res 1997; 34:81-002.
13. Brüne B, Von Knethen A, Sandau KB. Nitric oxide and its role in apoptosis. Eur J Pharmacol 1998; 351:261-272.
14. Stoclet JC, Kleschyov A, Muller B, Lugnier C. New insights into the role of nitric oxide in cardiovascular protection. Exp Clin Cardiol 1997; 2:93-97.
15. György K, Muller B, Vegh A, Kleschyov A, Stoclet JC. Triggering role of nitric oxide in the delayed protective effect of monophosphoryl lipid A in rat heart. Br J Pharmacol 1999; 127: 1892-1898.