Riamet(TM). Antimalarial

Drugs of the Future

Volumn 24, Issue 11, 1999, Pages 1203-1211

  Neuman, M ^a   Rabasseda, X ^b  

^a université Paris Cité   (France)

^b PROUS SCIENCE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL; ARTESUNATE; CHLOROQUINE; FANSIDAR; HALOFANTRINE; MEFLOQUINE; QUININE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; FATIGUE; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; MALARIA; MYALGIA; QT INTERVAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; SLEEP DISORDER;

EID: 0033369608     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1999.024.11.531934     Document Type: Review

References (21)

1. Winstanley, P., Olliaro, P. Clinical trials of chemotherpy for falciparum malaria. Exp Opin Invest Drugs 1998, 7: 261-71.
2. Zhou, Y., Ning, D., Wang, S., Ding, D., Li, G., Shan, C., Liu, G. (Ciba Geigy AG; Institute of Microbiology and Epidemiology). Antimalarial compsns. CA 2065285, CN 1058717, EP 500823, JP 92501568, US 5677331, WO 9202217.
3. Cumming, J.N., Ploypradith, P., Posner, G.H. Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: Mechanism(s) of action. Adv Pharmacol 1997, 37: 253-97.
4. Cumming, J.N., Wang, D., Park, S.B., Shapiro, T.A., Posner, G.H. Design, synthesis, derivatization, and structure-activity relationships of simplified tricyclic, 1,2,4-trioxane alcohol analogues of the antimalarial artemisinin. J Med Chem 1998, 41: 952-64.
5. Posner, G.H., Cumming, J.N., Ploypradith, P., Oh, O.H. Evidence for Fe(IV)=O in the molecular mechanism of action of the trioxane antimalarial artemisinin. J Am Chem Soc 1995, 117: 5885-6.
6. Posner, G.H., Cumming, J.N., Woo, S.H., Ploypradith, P., Xie, S., Shapiro, T.A. Orally active antimalarial 3-substituted trioxanes: New synthetic methodology and biological evaluation. J Med Chem 1998, 41: 940-51.
7. Paitayatat, S., Tamchompoo, B., Thebtaranonth, Y., Yuthavong, Y. Correlation of antimalarial activity of artemisinin derivatives with binding affinity with ferroprotoporphyrin IX. J Med Chem 1997, 40: 633-8.
8. Ezzet, F., Mull, R., Karbwang, J. Population pharmacokinetics and therapeutic response of CGP 56697 (artemether + benflumetol) in malaria patients. Br J Clin Pharmacol 1998, 46: 553-61.
9. van Agtmael, M.A., Cheng-Qi, S., Qing, J.X., Mull, R., van Boxtel, C.J. Multiple dose pharmacokinetics of artemether in Chinese patients with uncomplicated falciparum malaria. Int J Antimicrob Agents 1999, 12: 151-8.
10. Bindschedler, Degen, L., Lu, Z.L., Liu, G.Y., Fan, F. Comparative bioavailability of benflumetol after administration of single oral doses of co-artemether under fed and fasted conditions to healthy subjects. 14th Int Cong Trop Med Malar (Nov 17-22, Nagasaki) 1996, Abst P-01-96.
11. von Seidlein, L., Jaffar, S., Pinder, M., Haywood, M., Snounou, G., Gemperli, B., Gathmann, I., Royce, C., Greenwood, B. Treatment of African children with unomplicated falciparum malaria with a new antimalaria drug, CGP 56697. J Infect Dis 1997, 176: 1113-6.
12. Jiao, X., Liu, G.Y., Shan, C.O., Zhao, X., Li, X.W., Gathmann, I., Royce, C. Phase II trial in China of a new, rapidly-acting and effective oral antimalarial, CGP 56697, for the treatment of Plasmodium falciparum malaria. Southeast Asian J Trop Med Public Health 1997, 28: 476-81.
13. Hatz, C., Abdulla, S., Mull, R., Gathmann, I., Royce, C. Efficacy of CGP 56697 vs. chloroquine for treatment of P. falciparum malaria in young symptomatic children in Tanzania. Clin Microbiol Infect 1997, 3 (Suppl. 2): Abst P753b.
14. Hatz, C., Abdulla, S., Mull, R., Schellenberg, D., Gathmann, I., Kibatala, P., Beck, H.P., Tanner, M., Royce, C.Efficacy and safety of CGP 56697 (artemether and benflumetol) compared with chloroquine to treat acute falciparum malaria in Tanzanian children aged 1-5 years. Trop Med Int Health 1998, 3: 498-504.
15. Sabchareon, A., Attanath, P., Gathmann, I. et al. An open comparative 28 day trial of CGP 56697 (2 days) versus oral quinine (8 days) in the treatment of acute P. falciparum malaria in Thai children. J Clin Microbiol Infect 1997, 3 (Suppl. 2): Abst P752.
16. Looareesuwan, S., Wilairatana, P., Chokejindachai, W., Chalermrut, K., Wernsdorfer, W., Gemperli, B., Gathmann, I., Royce, C. A randomized, double-blind, comparative trial of a new oral combination of artemether and benflumetol (CGP 56697) with mefloquine in the treatment of acute Plasmodium falciparum malaria in Thailand. Am J Trop Med Hyg 1999, 60: 238-43.
17. van Agtmael, M., Bouchaud, O., Malvy, D. et al. A randomised, double-blind trial of CGP 56697 versus halofantrine in the treatment of Plasmodium falciparum malaria in Europe. Clin Microbiol Infect 1997, 3 (Suppl. 2): Abst P754.
18. van Agtmael, M., Bouchaud, O., Malvy, D. et al. The comparative efficacy and tolerability of CGP 56697 (artemether + lumefantrine) versus halofantrine in the treatment of uncomplicated falciparum malaria in travellers returning from the tropics to the Netherlands and France. Int J Antimicrob Agents 1999, 12: 159-69.
19. von Seidlein, L., Bojang, K., Jones, P. et al. A randomized controlled trial of artemether/benflumetol, a new antimalarial and pyrimethamine/sulfadoxine in the treatment of uncomplicated falciparum malaria in African children. Am J Trop Med Hyg 1998, 58: 638-44.
20. van Vugt, M., Brockman, A., Gemperli, B., Luxemburger, C., Gathmann, I., Royce, C., Slight, T., Looareesuwan, S., White, N.J., Nosten, F. Randomized comparison of artemether-benflumetol and artesunate-mefloquine in treatment of multidrug-resistant falciparum malaria. Antimicrob Agents Chemother 1998, 42: 135-9.
21. van Vugt, M., Wilairatama, P., Gemperli, B., Gathmann, I., Royce, C., Nosten, F., White, N., Looareesuwan, S. Double-blind, randomised trial of standard and high dose regimens of CGP 56697, a new oral antimalarial combination in the treatment of multi-drug resistant Plasmodium falciparum malaria in Thailand. Clin Microbiol Infect 1997, 3 (Suppl. 2): Abst. P753a.