Model for assessing efficacy of topical skin protectants against sulfur mustard vapor using hairless guinea pigs

Journal of Applied Toxicology

Volumn 19, Issue SUPPL. 1, 1999, Pages

  Snider, T H ^a   Matthews, M C ^a   Braue Jr , E H ^b  

^a BATTELLE MEMORIAL INSTITUTE   (United States)

^b US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Blister; Dermal exposure; Erythema; Hairless guinea pig; Histopathology; Sulfur mustard

Indexed keywords

MUSTARD GAS; SKIN PROTECTIVE AGENT;

ALOPECIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CHRONOLOGY; CONFERENCE PAPER; DRUG EFFICACY; DRUG SCREENING; EPIDERMIS; ERYTHEMA; EXPOSURE; GUINEA PIG; HISTOPATHOLOGIC SKIN REACTION; NONHUMAN; PRIORITY JOURNAL; REFLECTOMETRY;

ADMINISTRATION, TOPICAL; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHEMA; GUINEA PIGS; MUSTARD GAS; PROTECTIVE AGENTS; SKIN; VOLATILIZATION;

ANIMALIA; CAVIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0033368124     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1263(199912)19:1+3.0.CO;2-W     Document Type: Conference Paper

References (7)

1. D. D. Marlow, M. M. Mershon, L. W. Mitcheltree, J. P. Petrali and G. P. Jaxx, Sulfur mustard-induced skin injury in hairless guinea pigs. J. Toxicol. Cut. Ocular Toxicol. 9, 179-192 (1990).
2. E. H. Braue, Jr., I. Koplovitz, L. W. Mitcheltree, E. T. Clayson, M. R. Litchfield and C. R. Bangledorf, Characterization of the sulfur mustard vapor induced cutaneous lesions on hairless guinea pigs. Toxicol. Methods 2, 242-254 (1992).
3. J. J. Yourick, C. R. Clark and L. W. Mitcheltree, Niacinamide pretreatment reduces microvesicle formation in sulfur mustard cutaneously exposed hairless guinea pigs. Toxicologist 11, 284 (1991).
4. J. J. Yourick, J. S. Dawson and L. W. Mitcheltree, Sulfur mustard-induced microvesication in hairless guinea pigs: effect of short-term niacinamide administration. Toxicol. Appl. Pharmacol. 117, 104-109 (1992).
5. J. J. Yourick, J. S. Dawson, C. D. Benton, M. E. Craig and L. W. Mitcheltree, Pathogenesis of 2,2′-dichloroethyl sulfide in hairless guinea pigs. Toxicology 84, 185-197 (1993).
6. J. W. Tukey, Comparing individual means in the analysis of variance. Biometrics 5, 99-114 (1949).
7. E. H. Braue, Jr., C. R. Nalls, R. A. Way, J. E. Zallnick, R. G. Rieder and L. W. Mitcheltree, Nikolsky's sign: a novel way to evaluate damage at the dermal-epidermal junction. Skin Res. Tech. 3, 245-251 (1997).