Nikolsky's sign: A novel way to evaluate damage at the dermal-epidermal junction

Skin Research and Technology

Volumn 3, Issue 4, 1997, Pages 245-251

  Braue Jr , E H ^a   Nalls, C R ^a   Way, R A ^a   Zallnick, J E ^a   Rieder, R G ^a   Mitcheltree, L W ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Dermal torque meter; Hairless guinea pig; Nikolsky's sign; Sulfur mustard; Vesicant animal model

Indexed keywords

ADHESIVE AGENT; CYANOACRYLATE; MUSTARD GAS; NIKOLSKY PHENOMENON; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASAL CELL; CONTROLLED STUDY; DERMOEPIDERMAL JUNCTION; DISEASE SEVERITY; DRUG SCREENING; EPIDERMIS; GUINEA PIG; HISTOPATHOLOGY; MALE; NONHUMAN; REPRODUCIBILITY; TISSUE INJURY; TORQUE;

EID: 0030700725     PISSN: 0909752X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0846.1997.tb00193.x     Document Type: Article

References (14)

1. Papirmeister B, Feister AJ, Robinson SI, Ford RD. Medical defense against mustard gas: toxic mechanisms and pharmacological implications. Boston: CRC Press, 1991: 43-78.
2. Renshaw B. Mechanisms in production of cutaneous injuries by sulfur and nitrogen mustards. In: Chemical warfare agents and related chemical problems. Washington, DC: National Defense Research Committee, 1946: Vol 2, Part 3: 479-520.
3. Braue Jr EH, Koplovitz I, Mitcheltree LW, Clayson ET, Litchfield MR, Bangledorf CR. Characterization of the sulfur mustard vapor induced cutaneous lesions on hairless guinea pigs. Toxicol Methods 1992: 2: 242-254.
4. Braue Jr EH, Mershon MM, Larsen T, et al. Assessment of antivesicant compounds using the hairless guinea pig. Proceedings of the 1991 Medical Defense Bioscience Review, U.S. Army Medical Research Institute of Chemical Defense, AD B158588, 1991: 9-16.
5. Goodman H. Nikolsky sign. Arch Dermatol Syphilol 1953: 68: 334-335.
6. Polifka M, Krusinski PA. The Nikolsky sign. CUTIS 1980: 26: 521-526.
7. Doubleday CW. Who is Nikolsky and what does his sign mean? J Am Acad Dermatol 1987: 16: 1054-1055.
8. Yourick JJ, Clark CR, Mitcheltree LW. Niacinamide pre-treatment reduces microvesicle formation in hairless guinea pigs cutaneously exposed to sulfur mustard. Fundam Appl Toxicol 1991: 17: 533-542.
9. Braue Jr EH, Mershon MM, Wade JV, Litchfield MR. In vivo assessment of vesicant skin injury using a Minolta Chroma Meter. J Soc Cosmet Chem 1990: 41: 259-265.
10. Mershon MM, Wade JV, Mitcheltree LW, Petrali JP, Braue Jr EH. Hairless guinea pig bioassay model for vesicant vapor exposure. Fundam Appl Toxicol 1990: 15: 622-630.
11. Redemann CE, Chaikin SW, Fearing RB. The volatility and vapor pressure of eight 2-chloroethyl alkyl (or cycloalkyl) sulfides. Amer Chem Soc 1948: 70: 631-632.
12. Bommannan D, Potts RO, Guy RH. Examination of stratum corneum barrier function in vivo by infrared spectroscopy. J Invest Dermatol 1990: 95: 403-408.
13. Pinkus H. Tape stripping in dermatological research. A review with emphasis on epidermal biology. Giorn Ital Derm 1965: 107: 1115-1126.
14. Agache, PG. Twistometry measurement of the skin elasticity. In: Serup J, Jemed GBE, eds. Handbook of non-invasive methods and the skin. Boca Raton: CRC Press, 1995: 319-328.