-
1
-
-
0025325071
-
Evaluation of the antitumor activity of a (2′,2′-difluoro-2′-deoxycytidine)
-
Hertel LW, Boder B, Kroin JS, Rinzel SM, Poore GA, Todd GC and Grindey GB: Evaluation of the antitumor activity of a (2′,2′-difluoro-2′-deoxycytidine). Cancer Res 50: 4417-4422, 1990.
-
(1990)
Cancer Res
, vol.50
, pp. 4417-4422
-
-
Hertel, L.W.1
Boder, B.2
Kroin, J.S.3
Rinzel, S.M.4
Poore, G.A.5
Todd, G.C.6
Grindey, G.B.7
-
2
-
-
0029554396
-
New anticancer agents in clinical development
-
Eckardt J, Eckhardt G, Villalona-Calero M, Drengler R and Von Hoff D: New anticancer agents in clinical development. Oncology 9: 1321-1331, 1995.
-
(1995)
Oncology
, vol.9
, pp. 1321-1331
-
-
Eckardt, J.1
Eckhardt, G.2
Villalona-Calero, M.3
Drengler, R.4
Von Hoff, D.5
-
3
-
-
0028033227
-
Single agent activity of weekly gemcitabine in advanced non-small-cell lung cancer: A phase II study
-
Anderson H, Lund B, Bach F, Thatcher N, Walling J and Hansen HH: Single agent activity of weekly gemcitabine in advanced non-small-cell lung cancer: a phase II study. J Clin Oncol 12: 1821-1826, 1994.
-
(1994)
J Clin Oncol
, vol.12
, pp. 1821-1826
-
-
Anderson, H.1
Lund, B.2
Bach, F.3
Thatcher, N.4
Walling, J.5
Hansen, H.H.6
-
4
-
-
0028297564
-
Gemcitabine is an active new agent in previously untreated extensive small cell lung cancer (SCLC): A study of National Cancer Institute of Canada Clinical Trials Group
-
Cormier Y, Eisenhauer E, Muldal A, Gregg R, Ayoub J, Goss G, Stewart D, Tarasoff P and Wong D: Gemcitabine is an active new agent in previously untreated extensive small cell lung cancer (SCLC): a study of National Cancer Institute of Canada Clinical Trials Group. Ann Oncol 5: 283-285, 1994.
-
(1994)
Ann Oncol
, vol.5
, pp. 283-285
-
-
Cormier, Y.1
Eisenhauer, E.2
Muldal, A.3
Gregg, R.4
Ayoub, J.5
Goss, G.6
Stewart, D.7
Tarasoff, P.8
Wong, D.9
-
5
-
-
0026324313
-
Action of 2′,2′-difluorodeoxycytidine on DNA synthesis
-
Huang P, Chubb S, Hertel LW, Grindey GB and Plunkett W: Action of 2′,2′-difluorodeoxycytidine on DNA synthesis. Cancer Res 51: 6110-6117, 1991.
-
(1991)
Cancer Res
, vol.51
, pp. 6110-6117
-
-
Huang, P.1
Chubb, S.2
Hertel, L.W.3
Grindey, G.B.4
Plunkett, W.5
-
6
-
-
0029782426
-
Excision of 2′,2′-difluorodeoxycytidine (gemcitabine) monophosphate residues from DNA
-
Gandhi V, Legha J, Chen F, Hertel LW and Plunkett W: Excision of 2′,2′-difluorodeoxycytidine (gemcitabine) monophosphate residues from DNA. Cancer Res 56: 4453-4459, 1996.
-
(1996)
Cancer Res
, vol.56
, pp. 4453-4459
-
-
Gandhi, V.1
Legha, J.2
Chen, F.3
Hertel, L.W.4
Plunkett, W.5
-
7
-
-
0028832342
-
Gemcitabine: A modulator of intracellular nucleotide and deoxynucleotide metabolism
-
Heinemann V, Schulz L, Issels RD and Plunkett W: Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism. Semin Oncol 22 (4 Suppl 11): 11-18, 1995.
-
(1995)
Semin Oncol
, vol.22
, Issue.4 SUPPL. 11
, pp. 11-18
-
-
Heinemann, V.1
Schulz, L.2
Issels, R.D.3
Plunkett, W.4
-
8
-
-
0023552964
-
Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxy-camptothecin, a novel water-soluble derivative of camptothecin, against murine tumors
-
Kunimoto T, Nitta K, Tanaka T, Uehara N, Baba H, Takeuchi M, Yokokura T, Sawada S, Miyasaka T and Mutai M: Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxy-camptothecin, a novel water-soluble derivative of camptothecin, against murine tumors. Cancer Res 47: 5944-5947, 1987.
-
(1987)
Cancer Res
, vol.47
, pp. 5944-5947
-
-
Kunimoto, T.1
Nitta, K.2
Tanaka, T.3
Uehara, N.4
Baba, H.5
Takeuchi, M.6
Yokokura, T.7
Sawada, S.8
Miyasaka, T.9
Mutai, M.10
-
9
-
-
0025996996
-
Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11
-
Kawato Y, Aonuma M, Hirota Y, Kuga H and Sato K: Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res 51: 4187-4191, 1991.
-
(1991)
Cancer Res
, vol.51
, pp. 4187-4191
-
-
Kawato, Y.1
Aonuma, M.2
Hirota, Y.3
Kuga, H.4
Sato, K.5
-
10
-
-
0028221421
-
Activity of CPT-11 (irinotecan hydrochloride), a topoisomerase I inhibitor, against human tumor colony-forming units
-
Shimada Y, Rothenberg ML, Hilsenbeck SG, Burris HA III, Degen D and Von Hoff DD: Activity of CPT-11 (irinotecan hydrochloride), a topoisomerase I inhibitor, against human tumor colony-forming units. Anticancer Drugs 5: 202-206, 1994.
-
(1994)
Anticancer Drugs
, vol.5
, pp. 202-206
-
-
Shimada, Y.1
Rothenberg, M.L.2
Hilsenbeck, S.G.3
Burris III, H.A.4
Degen, D.5
Von Hoff, D.D.6
-
11
-
-
0025785082
-
Antitumor activity of a camptothecin derivative, CPT-11, against humor tumor xenografts in nude mice
-
Kawato Y, Furuta T, Aonuma M, Yasuoka T and Matsumoto K: Antitumor activity of a camptothecin derivative, CPT-11, against humor tumor xenografts in nude mice. Cancer Chemother Pharmacol 28: 192-198, 1991.
-
(1991)
Cancer Chemother Pharmacol
, vol.28
, pp. 192-198
-
-
Kawato, Y.1
Furuta, T.2
Aonuma, M.3
Yasuoka, T.4
Matsumoto, K.5
-
12
-
-
0023864510
-
Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo
-
Tsuruo T, Matsuzaki T, Matsushita M, Saito H and Yokokura T: Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo. Cancer Chemother Pharmacol 21: 71-74, 1988.
-
(1988)
Cancer Chemother Pharmacol
, vol.21
, pp. 71-74
-
-
Tsuruo, T.1
Matsuzaki, T.2
Matsushita, M.3
Saito, H.4
Yokokura, T.5
-
13
-
-
0027194943
-
Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer
-
CPT-11 Gastrointestinal Cancer Study Group
-
Shimada Y, Yoshino M, Wakui A, Nakao I, Sakata Y, Kambe M, Taguchi T and Ogawa N: Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer. CPT-11 Gastrointestinal Cancer Study Group. J Clin Oncol 11: 909-913, 1993.
-
(1993)
J Clin Oncol
, vol.11
, pp. 909-913
-
-
Shimada, Y.1
Yoshino, M.2
Wakui, A.3
Nakao, I.4
Sakata, Y.5
Kambe, M.6
Taguchi, T.7
Ogawa, N.8
-
14
-
-
0029966672
-
Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer
-
Rothenberg ML, Eckardt JR, Kuhn JG, Burris HA III, Nelson J, Hilsenbeck SG, Rodriguez GI, Thurman AM, Smith LS, Eckhardt SG, Weiss GR, Elfring GL, Rinaldi DA, Schaaf LJ and Von Hoff DD: Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer. J Clin Oncol 14: 1128-1135, 1996.
-
(1996)
J Clin Oncol
, vol.14
, pp. 1128-1135
-
-
Rothenberg, M.L.1
Eckardt, J.R.2
Kuhn, J.G.3
Burris III, H.A.4
Nelson, J.5
Hilsenbeck, S.G.6
Rodriguez, G.I.7
Thurman, A.M.8
Smith, L.S.9
Eckhardt, S.G.10
Weiss, G.R.11
Elfring, G.L.12
Rinaldi, D.A.13
Schaaf, L.J.14
Von Hoff, D.D.15
-
15
-
-
0026680292
-
CPT-11: A new derivative of camptothecin for the treatment of refractory or relapsed small-cell lung cancer
-
Masuda N, Fukuoka M, Kusunoki Y, Matsui K, Takifuji N, Kudoh S, Negoro S, Nishioka M, Nakagawa K and Takada M: CPT-11: a new derivative of camptothecin for the treatment of refractory or relapsed small-cell lung cancer. J Clin Oncol 10: 1225-1229, 1992.
-
(1992)
J Clin Oncol
, vol.10
, pp. 1225-1229
-
-
Masuda, N.1
Fukuoka, M.2
Kusunoki, Y.3
Matsui, K.4
Takifuji, N.5
Kudoh, S.6
Negoro, S.7
Nishioka, M.8
Nakagawa, K.9
Takada, M.10
-
16
-
-
0026531753
-
A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer
-
Fukuoka M, Niitani H, Suzuki A, Motomiya M, Hasegawa K, Nishiwaki Y, Kuriyama T, Ariyoshi Y, Negoro S, Masuda N et al: A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer. J Clin Oncol 10: 16-20, 1992.
-
(1992)
J Clin Oncol
, vol.10
, pp. 16-20
-
-
Fukuoka, M.1
Niitani, H.2
Suzuki, A.3
Motomiya, M.4
Hasegawa, K.5
Nishiwaki, Y.6
Kuriyama, T.7
Ariyoshi, Y.8
Negoro, S.9
Masuda, N.10
-
17
-
-
0032168956
-
A phase II trial of CPT-11 in recurrent squamous carcinoma of the cervix: A gynecologic oncology study group
-
Look KY, Blessing JA, Levenback C, Kohler M, Chafe W and Roman LD: A phase II trial of CPT-11 in recurrent squamous carcinoma of the cervix: a gynecologic oncology study group. Gynecol Oncol 70: 334-338, 1998.
-
(1998)
Gynecol Oncol
, vol.70
, pp. 334-338
-
-
Look, K.Y.1
Blessing, J.A.2
Levenback, C.3
Kohler, M.4
Chafe, W.5
Roman, L.D.6
-
18
-
-
0025899042
-
A late phase II study of CPT-11 on uterine cervical cancer and ovarian cancer
-
Research Groups of CPT-11 in Gynecologic Cancers
-
Takeuchi S, Dobashi K, Fujimoto S, Tanaka K, Suzuki M, Terashima Y, Hasumi K, Akiya K, Negishi Y, Tamaya T, et al: A late phase II study of CPT-11 on uterine cervical cancer and ovarian cancer. Research Groups of CPT-11 in Gynecologic Cancers. Jpn J Chemother 18: 1681-1689, 1991.
-
(1991)
Jpn J Chemother
, vol.18
, pp. 1681-1689
-
-
Takeuchi, S.1
Dobashi, K.2
Fujimoto, S.3
Tanaka, K.4
Suzuki, M.5
Terashima, Y.6
Hasumi, K.7
Akiya, K.8
Negishi, Y.9
Tamaya, T.10
-
19
-
-
0026572562
-
Megestrol acetate reverses multidrug resistance and interacts with P-glycoprotein
-
Fleming GF, Amato JM, Agresti M and Safa AR: Megestrol acetate reverses multidrug resistance and interacts with P-glycoprotein. Cancer Chemother Pharmacol 29: 445-459, 1992.
-
(1992)
Cancer Chemother Pharmacol
, vol.29
, pp. 445-459
-
-
Fleming, G.F.1
Amato, J.M.2
Agresti, M.3
Safa, A.R.4
-
20
-
-
0024847290
-
What is synergy?
-
Berenbaum MC: What is synergy? Pharmacol Rev 41: 93-141, 1990.
-
(1990)
Pharmacol Rev
, vol.41
, pp. 93-141
-
-
Berenbaum, M.C.1
-
21
-
-
0021118703
-
Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
-
Chou T-C and Talalay P: Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22: 27-55, 1984.
-
(1984)
Adv Enzyme Regul
, vol.22
, pp. 27-55
-
-
Chou, T.-C.1
Talalay, P.2
-
22
-
-
0027993707
-
Efficacy and safety profile of gemcitabine in non-small-cell lung cancer: A phase II study
-
Abratt RP, Bezwoda WR, Falkson G, Goedhals L, Hacking D and Rugg TA: Efficacy and safety profile of gemcitabine in non-small-cell lung cancer: a phase II study. J Clin Oncol 12: 1535-1540, 1994.
-
(1994)
J Clin Oncol
, vol.12
, pp. 1535-1540
-
-
Abratt, R.P.1
Bezwoda, W.R.2
Falkson, G.3
Goedhals, L.4
Hacking, D.5
Rugg, T.A.6
-
23
-
-
0029914387
-
Activity of gemcitabine in patients with non-small cell lung cancer: A multicentre, extended phase II study
-
Gatzemeier U, Shepherd FA, Le Chevalier T, Weynants P, Cottier B, Groen HJ, Rosso R, Mattson K, Cortes-Funes H, Tonato M, Burkes RL, Gottfried M and Voi M: Activity of gemcitabine in patients with non-small cell lung cancer: a multicentre, extended phase II study. Eur J Cancer 32: 243-248, 1996.
-
(1996)
Eur J Cancer
, vol.32
, pp. 243-248
-
-
Gatzemeier, U.1
Shepherd, F.A.2
Le Chevalier, T.3
Weynants, P.4
Cottier, B.5
Groen, H.J.6
Rosso, R.7
Mattson, K.8
Cortes-Funes, H.9
Tonato, M.10
Burkes, R.L.11
Gottfried, M.12
Voi, M.13
-
24
-
-
0028020890
-
Phase II study of gemcitabine (2′,2′-difluorodeoxycytidine) in previously treated ovarian cancer patients
-
Lund B, Hansen OP, Theilade K, Hansen M and Neijt JP: Phase II study of gemcitabine (2′,2′-difluorodeoxycytidine) in previously treated ovarian cancer patients. J Natl Cancer Inst 86: 1530-1533, 1994.
-
(1994)
J Natl Cancer Inst
, vol.86
, pp. 1530-1533
-
-
Lund, B.1
Hansen, O.P.2
Theilade, K.3
Hansen, M.4
Neijt, J.P.5
-
25
-
-
0028799915
-
Advanced breast cancer: A phase II trial with gemcitabine
-
Carmichael J, Possinger K, Philip P, Beykirch M, Kerr H, Walling J and Harris AL: Advanced breast cancer: a phase II trial with gemcitabine. J Clin Oncol 13: 2731-2736, 1995.
-
(1995)
J Clin Oncol
, vol.13
, pp. 2731-2736
-
-
Carmichael, J.1
Possinger, K.2
Philip, P.3
Beykirch, M.4
Kerr, H.5
Walling, J.6
Harris, A.L.7
-
26
-
-
0030698628
-
Phase II study of single-agent gemcitabine in previously untreated patients with metastatic urothelial cancer
-
Stadler WM, Kuzel T, Roth B, Raghavan D and Dorr FA: Phase II study of single-agent gemcitabine in previously untreated patients with metastatic urothelial cancer. J Clin Oncol 15: 3394-3398, 1997.
-
(1997)
J Clin Oncol
, vol.15
, pp. 3394-3398
-
-
Stadler, W.M.1
Kuzel, T.2
Roth, B.3
Raghavan, D.4
Dorr, F.A.5
-
27
-
-
0030686593
-
Gemcitabine: A promising new agent in the treatment of advanced urothelial cancer
-
Moore MJ, Tannock IF, Ernst DS, Huan S and Murray N: Gemcitabine: a promising new agent in the treatment of advanced urothelial cancer. J Clin Oncol 15: 3441-3445, 1997.
-
(1997)
J Clin Oncol
, vol.15
, pp. 3441-3445
-
-
Moore, M.J.1
Tannock, I.F.2
Ernst, D.S.3
Huan, S.4
Murray, N.5
-
28
-
-
0028292341
-
Phase II trial of gemcitabine (2′,2′-difluorodeoxycytidine) in patients with adenocarcinoma of the pancreas
-
Casper ES, Green MR, Kelsen DP, Heelan RT, Brown TD, Flombaum CD, Trochanowski B and Tarassoff PG: Phase II trial of gemcitabine (2′,2′-difluorodeoxycytidine) in patients with adenocarcinoma of the pancreas. Invest New Drugs 12: 29-32, 1994.
-
(1994)
Invest New Drugs
, vol.12
, pp. 29-32
-
-
Casper, E.S.1
Green, M.R.2
Kelsen, D.P.3
Heelan, R.T.4
Brown, T.D.5
Flombaum, C.D.6
Trochanowski, B.7
Tarassoff, P.G.8
-
29
-
-
0030049697
-
Phase II study of gemcitabine in patients with advanced pancreatic cancer
-
Carmichael J, Fink U, Russell RC, Spittle MF, Harris AL, Spiessi G and Blatter J: Phase II study of gemcitabine in patients with advanced pancreatic cancer. Br J Cancer 73: 101-105, 1996.
-
(1996)
Br J Cancer
, vol.73
, pp. 101-105
-
-
Carmichael, J.1
Fink, U.2
Russell, R.C.3
Spittle, M.F.4
Harris, A.L.5
Spiessi, G.6
Blatter, J.7
-
30
-
-
0028236635
-
A late phase II study of CPT-11, irinotecan hydrochloride, in patients with advanced pancreatic cancer
-
CPT-11 study group on gastrointestinal cancer
-
Sakata Y, Shimada Y, Yoshino M, Kambe M, Futatsuki K, Nakao I, Ogawa N, Wakui A and Taguchi T: A late phase II study of CPT-11, irinotecan hydrochloride, in patients with advanced pancreatic cancer. CPT-11 study group on gastrointestinal cancer. Jpn J Cancer Chemother 21: 1039-1046, 1994.
-
(1994)
Jpn J Cancer Chemother
, vol.21
, pp. 1039-1046
-
-
Sakata, Y.1
Shimada, Y.2
Yoshino, M.3
Kambe, M.4
Futatsuki, K.5
Nakao, I.6
Ogawa, N.7
Wakui, A.8
Taguchi, T.9
-
31
-
-
0030883212
-
Clinical pharmacokinetics of irinotecan
-
Chabot GG: Clinical pharmacokinetics of irinotecan. Clin Pharmacokinet 33: 245-259, 1997
-
(1997)
Clin Pharmacokinet
, vol.33
, pp. 245-259
-
-
Chabot, G.G.1
-
32
-
-
0029852961
-
Phase I studies with the novel nucleoside analog gemcitabine
-
Abbruzzese JL: Phase I studies with the novel nucleoside analog gemcitabine. Semin Oncol 23: 24-31, 1996.
-
(1996)
Semin Oncol
, vol.23
, pp. 24-31
-
-
Abbruzzese, J.L.1
-
33
-
-
0030944603
-
In vitro interaction between gemcitabine and other anticancer drugs using a novel three-dimensional model
-
Kanzawa F and Saijo N: In vitro interaction between gemcitabine and other anticancer drugs using a novel three-dimensional model. Semin Oncol 24 (2 Suppl 7): S7-8-S7-16, 1997.
-
(1997)
Semin Oncol
, vol.24
, Issue.2 SUPPL. 7
-
-
Kanzawa, F.1
Saijo, N.2
|