Effectiveness of extreme discordant sib pairs to detect oligogenic disease loci

Genetic Epidemiology

Volumn 14, Issue 6, 1997, Pages 879-884

  Rogus, John J ^a   Harrington, David P ^a,b   Jorgenson, Eric ^c   Xu, Xiping ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

Extreme discordant sib pair; Genomic screening; Linkage analysis

Indexed keywords

CONFERENCE PAPER; GENETIC LINKAGE; GENOME; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR GENE; QUANTITATIVE TRAIT; SCORING SYSTEM; SIBLING; TWIN DISCORDANCE;

CHROMOSOME MAPPING; COMPUTER SIMULATION; FEMALE; GENETIC DISEASES, INBORN; GENETIC SCREENING; GENOME, HUMAN; HUMANS; MALE; MATCHED-PAIR ANALYSIS; NUCLEAR FAMILY; QUANTITATIVE TRAIT, HERITABLE; RECOMBINATION, GENETIC; VARIATION (GENETICS);

EID: 0031455772     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2272(1997)14:6<879::AID-GEPI53>3.0.CO;2-J     Document Type: Conference Paper

References (5)

1. Holmans P (1993): Asymptotic properties of affected-sib-pair linkage analysis. Am J Hum Genet 52:362-374.
2. Kruglyak L, Lander ES (1995): Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet 57:439-454.
3. Lander E, Kruglyak L (1995): Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet 11:241-247.
4. Risch N, Zhang H (1995): Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science 268:1584-1589.
5. Risch NJ, Zhang H (1996): Mapping quantitative trait loci with extreme discordant sib pairs: Sampling considerations. Am J Hum Genet 58:836-843.