Glucocorticoids differentially inhibit expression of the RET proto-oncogene

Gene Expression

Volumn 8, Issue 5-6, 1999, Pages 311-326

  Capes Davis, Amanda ^a   Andrew, Scott D ^a   Hyland, Valentine J ^a   Twigg, Stephen ^a   Learoyd, Diana L ^a   Dwight, Trisha ^a   Marsh, Debbie J ^a   Robinson, Bruce G ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ROYAL NORTH SHORE HOSPITAL   (Australia)

Author keywords

Alternative splicing; Dexamethasone; Gene expression; Multiple endocrine neoplasia type 2; RET proto oncogene

Indexed keywords

DEXAMETHASONE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLUCOCORTICOID; MESSENGER RNA; TYROSINE KINASE RECEPTOR;

ALTERNATIVE RNA SPLICING; ARTICLE; CELL CULTURE; DOSE RESPONSE; ENZYME ACTIVATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE MUTATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MEDULLARY CARCINOMA; NORTHERN BLOTTING; ONCOGENE RET; PROTO ONCOGENE; RNA TRANSCRIPTION; SIPPLE SYNDROME; STEADY STATE;

CARCINOMA, MEDULLARY; CELL DIVISION; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; GLUCOCORTICOIDS; HUMANS; PREGNENEDIONES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; STEROIDS; THYROID NEOPLASMS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0033306859     PISSN: 10522166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Asai, N.; Iwashita, T.; Matsuyama, M.; Takahashi, M. Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations. Mol. Cell. Biol. 15:1613-1619; 1995.
2. Asai, N.; Murakami, H.; Iwashita, T.; Takahashi, M. A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with She adaptor proteins. J. Biol. Chem. 271:17644-17649; 1996.
3. Baloh, R. H.; Tansey, M. G.; Golden, J. P.; Creedon, D. J.; Heuckeroth, R. O.; Keck, C. L.; Zimonjic, D. B.; Popescu, N. C.; Johnson, E. M., Jr.; Milbrandt, J. TmR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. Neuron 18:793-802; 1997.
4. Baloh, R. H.; Tansey, M. G.; Lampe, P. A.; Fahrner, T. J.; Enomoto, H.; Simburger, K. S.; Leitner, M. L.; Araki, T.; Johnson, E. M., Jr.; Milbrandt, J. Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex. Neuron 21:1291-1302; 1998.
5. Bamberger, C. M.; Schulte, H. M.; Chrousos, G. P. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endoer. Rev. 17:245-261; 1996.
6. Bunone, G.; Borrello, M. G.; Picetti, R.; Bongarzone, I.; Peverali, F. A.; de Francisas, V.; Della Valle, G.; Pierotti, M. A. Induction of RET proto-oncogene expression in neuroblastoma cells precedes neuronal differentiation and is not mediated by protein synthesis. Exp. Cell Res. 217:92-99; 1995.
7. Capes-Davis, A.; Robinson, B. G.Return of the native: Deducing the normal function of the RET proto-oncogene. Curr. Opin. Endocrinol. Diabet. 6:61-69; 1999.
8. Carlomagno, F.; Salvatore, D.; Santoro, M.; de Franciscis, V.; Quadro, L.; Panariello, L.; Colantuoni, V.; Fusco, A. Point mutation of the RET proto-oncogene in the TT human medullary thyroid carcinoma cell line. Biochem. Biophys. Res. Commun. 207:1022-1028; 1995.
9. Carson, E. B.; McMahon, M.; Baylin, S. B.; Nelkin, B. D. Ret gene silencing is associated with Raf-1-induced medullary thyroid carcinoma cell differentiation. Cancer Res. 55:2048-2052; 1995.
10. Chambon, P.; Dierich, A.; Gaub, M. P.; Jakowlev, S.; Jongstra, J.; Krust, A.; LePennec, J. P.; Oudet, P.; Reudelhuber, T. Promoter elements of genes coding for proteins and modulation of transcription by estrogens and progesterone. Recent Prog. Horm. Res. 40:1-42; 1984.
11. Chomczynski, P. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques 15:532-537; 1993.
12. Clarke, C. L.; Graham, J.; Roman, S. D.; Sutherland, R. L. Direct transcriptional regulation of the progesterone receptor by retinoic acid diminishes progestin responsiveness in the breast cancer cell line T-47D. J. Biol. Chem. 266:18969-18975; 1991.
13. Colomer, A.; Martinez-Mas, J. V.; Matias-Guiu, X.; Llorens, A.; Cabezas, R.; Prat, J.; Garcia-Ameijeiras, A. Sex-steroid hormone receptors in human medullary thyroid carcinoma. Mod. Pathol. 9:68-72; 1996.
14. Cote, G. J.; Gagel, R. F. Dexamethasone differentially affects the levels of calcitonin and calcitonin gene-related peptide mRNAs expressed in a human medullary thyroid carcinoma cell line. J. Biol. Chem. 261:15524-15528; 1986.
15. Cowan, N. J.; Dobner, P. R.; Fuchs, E. V.; Cleveland, D. W. Expression of human alpha-tubulin genes: Interspecies conservation of 3' untranslated regions. Mol. Cell. Biol. 3:1738-1745; 1983.
16. Daly, R. J.; Darbre, P. D. Cellular and molecular events in loss of estrogen sensitivity in ZR-75-1 and T-47-D human breast cancer cells. Cancer Res. 50: 5868-5875; 1990.
17. de Bustros, A.; Baylin, S. B.; Berger, C. L.; Roos, B. A.; Leong, S. S.; Nelkin, B. D. Phorbol esters increase calcitonin gene transcription and decrease c-myc mRNA levels in cultured human medullary thyroid carcinoma. J. Biol. Chem. 260:98-104; 1985.
18. Drouin, J.; Trifiro, M. A.; Plante, R. K.; Nemer, M.; Eriksson, P.; Wrange, O. Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription. Mol. Cell. Biol. 9:5305-5314; 1989.
19. Durbec, P. L.; Larsson-Blomberg, L.; Schuchardt, A.; Costantini, F.; Pachnis, V. Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts. Development 122:349-358; 1996.
20. Eng, C. Seminars in medicine of the Beth Israel Hospital, Boston. The RET proto-oncogene in multiple endocrine neoplasia type 2 and Hirschsprung's disease. N. Engl. J. Med. 335:943-951; 1996.
21. Enokido, Y.; de Sauvage, F.; Hongo, J. A.; Ninkina, N.; Rosenthal, A.; Buchman, V. L.; Davies, A. M. GFRalpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin. Curr. Biol. 8: 1019-1022; 1998.
22. Fei, H.; Drake, T. A. A rapid nuclear runoff transcription assay. Biotechniques 15:838; 1993.
23. Greenberg, M. E. Identification of newly transcribed RNA: Nuclear runoff transcription in mammalian cells. In: Ausubel, F. M.; Brent, R.; Kingston, R. E.; Moore, D. D.; Seidman, J. G.; Smith, J. A.; Strahl, K., eds. Current protocols in molecular biology. New York: John Wiley & Sons; 1989:4.10.1-4.10.8.
24. Hollenberg, S. M.; Weinberger, C.; Ong, E. S.; Cerelli, G.; Oro, A.; Lebo, R.; Thompson, E. B.; Rosenfeld, M. G.; Evans, R. M. Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature 318:635-641; 1985.
25. Itoh, F.; Ishizaka, Y.; Tahira, T.; Yamamoto, M.; Miya, A.; Imai, K.; Yachi, A.; Takai, S.; Sugimura, T.; Nagao, M. Identification and analysis of the ret protooncogene promoter region in neuroblastoma cell lines and medullary thyroid carcinomas from MEN2A patients. Oncogene 7:1201-1206; 1992.
26. Jonat, C.; Rahmsdorf, H. J.; Park, K.-K.; Cato, A. C. B.; Gebel, S.; Ponta, H.; Herrlich, P. Antitumor promotion and antiinflammation: Down-modulation of AP-1 (fos/jun) activity by glucocorticoid hormone. Cell 62: 1189-1204; 1990.
27. Kotzbauer, P. T.; Lampe, P. A.; Heuckeroth, R. O.; Golden, J. P.; Creedon, D. J.; Johnson, E. M., Jr.; Milbrandt, J. Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature 384:467-470; 1996.
28. Laborda, J. 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein P0. Nucleic Acids Res. 19: 3998; 1991.
29. Lamari, Y.; Tahri, E. H.; Collignon, H.; Garel, J. M. Steroid hormones and retinoic acid interact in the regulation of calcitonin and calcitonin gene-related peptide secretion and messenger ribonucleic acid levels in CA-77 C cells. Cell. Mol. Biol. 40:541-550; 1994.
30. Leong, S. S.; Horoszewicz, J. S.; Shimaoka, K.; Friedman, M.; Kawinski, E.; Song, M. J.; Zeigel, R.; Chu, T. M.; Baylin, S.; Mirand, E. A. A new cell line for study of human medullary thyroid carcinoma. In: Andreoli, M.; Monaco, F.; Robbins, J., eds. Advances in thyroid neoplasia. Rome: Field Educational Italia; 1981:95-108.
31. Lin, L. F.; Doherty, D. H.; Lile, J. D.; Bektesh, S.; Collins, F. GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260:1130-1132; 1993.
32. Masiakowski, P.; Breathnach, R.; Bloch, J.; Gannon, F.; Krust, A.; Chambon, P. Cloning of cDNA se quences of hormone-regulated genes from the MCF-7 human breast cancer cell line. Nucleic Acids Res. 10: 7895-7903; 1982.
33. Moore, M. W.; Klein, R. D.; Farinas, I; Sauer, H.; Armanini, M.; Phillips, H.; Reichardt, L. F.; Ryan, A. M.; Carver-Moore, K.; Rosenthal, A. Renal and neuronal abnormalities in mice lacking GDNF. Nature 382:76-79; 1996.
34. Nakagawa, T.; Nelkin, B. D.; Baylin, S. B.; de Bustros, A. Transcriptional and posttranscriptional modulation of calcitonin gene expression by sodium n-butyrate in cultured human medullary thyroid carcinoma. Cancer Res. 48:2096-2100; 1988.
35. Pichel, J. G.; Shen, L.; Sheng, H. Z.; Granholm, A. C.; Drago, J.; Grinberg, A.; Lee, E. J.; Huang, S. P.; Saarma, M.; Hoffer, B. J.; Sariola, H.; Westphal, H. Defects in enteric innervation and kidney development in mice lacking GDNF. Nature 382:73-76; 1996.
36. Prins, G. S.; Woodham, C. Autologous regulation of androgen receptor messenger ribonucleic acid in the separate lobes of the rat prostate gland. Biol. Reprod. 53:609-619; 1996.
37. Ray, A.; Prefontaine, K. E. Physical association and functional antagonism between the p65 subunit of transcription factor NF-kB and the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 91:752-756; 1994.
38. Robertson, K.; Mason, I. Expression of ret in the chicken embryo suggests roles in regionalisation of the vagal neural tube and somites and in development of multiple neural crest and placodal lineages. Mech. Dev. 53:329-344; 1995.
39. Russo, A. F.; Nelson, C.; Roos, B. A.; Rosenfeld, M. G. Differential regulation of the coexpressed calcitonin/alpha-CGRP and beta-CGRP neuroendocrine genes. J. Biol. Chem. 263:5-8; 1988.
40. Russo, A. F.; Clark, M. S.; Durham, P. L. Thyroid parafollicular cells: An accessible model for the study of serotoncrgic neurons. Mol. Neurobiol. 13:257-275; 1996.
41. Sanchez, M. P.; Silos Santiago, I.; Frisen, J.; He, B.; Lira, S. A.; Barbacid, M. Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature 382:70-73; 1996.
42. Santoro, M.; Carlomagno, F.; Romano, A.; Boltaro, D. P.; Dathan, N. A.; Grieco, M.; Fusco, A.; Vecchio, G.; Matoskova, B.; Kraus, M. H.; Di Fiore, P. P. Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B. Science 267: 381-383; 1995.
43. Schuchardt, A.; D'Agati, V.; Larsson-Biomberg, L.; Costantini, F.; Pachnis, V. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature 367:380-383; 1994.
44. Songyang, Z.; Carraway, K. L.; Eck, M. J.; Harrison, S. C.; Feldman, R. A.; Mohammadi, M.; Schlessinger, J.; Hubbard, S. R.; Smith, D. P.; Eng, C.; Lorenzo, M. J.; Ponder, B. A.; Mayer, B. J.; Cantley, L. C. Catalytic specificity of protein tyrosine kinases is critical for selective signalling. Nature 373:536-539; 1995.
45. Tahira, T.; Ishizaka, Y.; Itoh, F.; Nakayasu, M.; Sugi- mura, T.; Nagao, M. Expression of the ret proto-oncogene in human neuroblastoma cell lines and its increase during neuronal differentiation induced by retinoic acid. Oncogene 6:2333-2338; 1991.
46. Trupp, M.; Arenas, E.; Fainzilber, M.; Nilsson, A.-S.; Sieber, B.-A.; Grigoriou, M.; Kilkenny, C.; SalazarGrueso, E.; Pachnis, V.; Arumae, U.; Sariola, H.; Saarma, M.; Ibanez, C. F. Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature 381:785-793; 1996.
47. Tverberg, L. A.; Russo, A. F. Cell-specific glucocorticoid repression of calcitonin/calcitonin gene-related peptide transcription. J. Biol. Chem. 267:17567-17573; 1992.
48. Yang-Yen, H. F.; Chambard, J. C.; Sun, Y. L.; Smeal, T.; Schmidt, T. J.; Drouin, J.; Karin, M. Transcriptional interference between c-jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62:1205-1215; 1990.