Cytochrome P4503A is the major source of N-vinylprotoporphyrin IX formation after administration of 3-[2-(2,4,6-trimethylphenyl)thioethyl]-4- methylsydnone to untreated and dexamethasone-pretreated rats

Drug Metabolism and Disposition

Volumn 24, Issue 8, 1996, Pages 872-878

  Mcnamee, James P ^a   Marks, Gerald S ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 MESITYLTHIOETHYL) 4 METHYLSYDNONE; BETA NAPHTHOFLAVONE; CYTOCHROME P450 ISOENZYME; DEXAMETHASONE; PHENOBARBITAL; PROTOPORPHYRIN; STEROID MONOOXYGENASE; SYDNONE DERIVATIVE; TROLEANDOMYCIN; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ALKYLATION; ANIMAL EXPERIMENT; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INACTIVATION; ISOMER; LIVER LEVEL; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; ENZYME INDUCTION; MALE; MICROSOMES, LIVER; NADP; PROTOPORPHYRINS; RATS; RATS, SPRAGUE-DAWLEY; SYDNONES;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0029788880     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

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