Glucocorticoid-remediable aldosteronism

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 12, 1999, Pages 4341-4344

  Dluhy, Robert G ^a   Lifton, Richard P ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; ANTIANDROGEN; CALCIUM CHANNEL BLOCKING AGENT; DIHYDROPYRIDINE DERIVATIVE; FUROSEMIDE; GLUCOCORTICOID; HORMONE ANTAGONIST; HYDROCHLOROTHIAZIDE; MINERALOCORTICOID; NIFEDIPINE; POTASSIUM SPARING DIURETIC AGENT; SPIRONOLACTONE; TRIAMTERENE;

CLINICAL FEATURE; DRUG MECHANISM; GENOTYPE; HEMORRHAGIC SHOCK; HORMONE SYNTHESIS; HUMAN; HYPERALDOSTERONISM; NOTE; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL;

EID: 0033305595     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.84.12.6256     Document Type: Note

References (14)

1. Hypertension, increased aldosterone secretion and low plasma renin activity relieved by dexamethasone
2. A new form of congenital adrenal hyperplasia
3. Defective fasciculata zone function as the mechanism of glucocorticoid-remediable aldosteronism
4. Intracranial aneurysm and hemorrhagic stroke in glucocorticoid-remediable aldosteronism
5. Familial, dexamethasone-suppressible, normokalemic hyperaldosteronism
6. Glucocorticoid-remediable aldosteronism in a large kindred: Clinical spectrum and diagnosis using a characteristic biochemical phenotype
7. A chimeric 11 β-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension
8. Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase
9. Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2
10. The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme
11. Recombinant CYP11B genes encode enzymes that can catalyze conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol, and 18-oxocortisol
12. Glucocorticoid-suppressible hyperaldosteronism: Effects of crossover site and parental origin of chimaeric gene on phenotypic expression
13. Evaluation of the dexamethasone suppression test for the diagnosis of glucocorticoid-remediable aldosteronism
14. A PCR-based method of screening individuals of all ages, from neonates to the elderly, for familial hyperaldosteronism type I