Delayed cell death, giant cell formation and chromosome instability induced by X-irradiation in human embryo cells

Journal of Radiation Research

Volumn 40, Issue 4, 1999, Pages 311-322

  Roy, Kanaklata ^a   Kodama, Seiji ^a   Suzuki, Keiji ^a   Watanabe, Masami ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

Chromosome instability; Delayed effect; Human cells; Potentially lethal damage repair; Radiation

Indexed keywords

CHROMOSOMES; IRRADIATION; RADIATION DAMAGE; REPAIR;

CELL FORMATION; CHROMOSOME ABERRATION; CHROMOSOME INSTABILITY; DAMAGE REPAIR; DELAYED EFFECTS; GIANT CELLS; HUMAN CELLS; HUMAN EMBRYO; POTENTIALLY LETHAL DAMAGE REPAIR; X-IRRADIATION;

CELL DEATH;

ARTICLE; CELL CULTURE; CELL DEATH; CHROMOSOME ABERRATION; EMBRYO; GIANT CELL; HUMAN; HUMAN CHROMOSOME; PATHOLOGY; RADIATION EXPOSURE; RADIATION INJURY; RADIATION RESPONSE; TIME; X RAY;

CELL DEATH; CELLS, CULTURED; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN; DOSE-RESPONSE RELATIONSHIP, RADIATION; EMBRYO; GIANT CELLS; HUMANS; RADIATION INJURIES; TIME FACTORS; X-RAYS;

EID: 0033291504     PISSN: 04493060     EISSN: None     Source Type: Journal    
DOI: 10.1269/jrr.40.311     Document Type: Article

References (32)

1. Ward, J. F. (1988) DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. Prog. Nucleic Acid Res. Mol. Biol. 35: 95-125.
2. Little, J. B. (1998) Radiation-induced genomic instability. Int. J. Radiat. Biol. 74: 663-671.
3. Seymour, C. B., Mothersill, C. and Alper, T. (1986) High yields of lethal mutations in somatic mammalian cells that survive ionizing radiation. Int. J. Radiat. Biol. 50: 167-179.
4. Chang, W. P. and Little, J. B. (1991) Delayed reproductive death in X-irradiated Chinese hamster ovary cells. Int. J. Radiat. Biol. 60: 483-496.
5. Chang, W. P. and Little, J. B. (1992) Evidence that DNA double-strand breaks initiate the phenotype of delayed reproductive death in Chinese hamster ovary cells. Radiat. Res. 131: 53-59.
6. Chang, W. P. and Little, J. B. (1992) Delayed reproductive death as a dominant phenotype in cell clones surviving X-irradiation. Carcinogenesis 13: 923-928.
7. Kadhim, M. A., Macdonald, D. A., Goodhead, D. T., Lorimore, S. A., Marsden, S. J. and Wright, E. G. (1992) Transmission of chromosomal instability after plutonium a-particle irradiation. Nature 355: 738-740.
8. Martins, M. B., Sabatier, L., Ricoul, M., Pinton, A. and Dutrillax, B. (1993) Specific chromosome instability induced by heavy ions: a step towards transformation of human fibroblasts? Mutat. Res. 285: 229-237.
9. Marder, B. A. and Morgan, W. F. (1993) Delayed chromosomal instability induced by DNA damage. Mol. Cell. Biol. 13: 6667-6677.
10. Holmberg, K., Fait, S., Johansson, A. and Lambert, B. (1993) Clonal chromosome aberrations and genomic instability in X-irradiated human T-lymphocyte cultures. Mutat. Res. 286: 321-330.
11. Little, J. B., Nagasawa, H., Pfenning, T. and Vetrovs, H. (1997) Radiation-induced genomic instability: delayed mutagenic and cytogenetic effects of X rays and alpha particles. Radiat. Res. 148: 299-307.
12. Nakanihi, M., Tanaka, K., Shintani, T., Takahashi, T. and Kamada, N. (1999) Chromosomal instability in acute myelocytic leukemia and myelodysplastic syndrome patients among atomic bomb survivors. J. Radiat. Res. 40: 159-167.
13. Brown, D. C. and Trott, K. R. (1994) Clonal heterogeneity in the progeny of HeLa cells which survive X-irradiation. Int. J. Radial. Biol. 66: 151-155.
14. Yang, Z., Kodama, S., Suzuki, K. and Watanabe, M. (1998) Telomerase activity, telomere length, and chromosome aberrations in the extension of life span of human embryo cells induced by low-dose X-rays. J. Radiat. Res. 39: 35-51.
15. Suzuki, M., Yang, Z., Nakano, K., Yatagai, F., Suzuki, K., Kodama, S. and Watanabe, M. (1998) Extension of in vitro life-span of γ-irradiated human embryo cells accompanied by chromosome instability. J. Radiat. Res. 39: 203-213.
16. Kodama, S., Komatsu, K., Okumura, Y. and Oshimura, M. (1992) Suppression of X-ray-induced chromosome aberrations in ataxia telangiectasia cells by introduction of a normal human chromosome 11. Mutat. Res. 293: 31-37.
17. Suzuki, K., Kodama, S. and Watanabe, M. (1998) Suppressive effect of low-dose preirradiation on genetic instability induced by X rays in normal human embryonic cells. Radiat. Res. 150: 656-662.
18. Utsumi, H. and Elkind, M. M. (1985) Two forms of potentially lethal damage have similar repair kinetics in plateau-and log-phase cells. Int. J. Radiat. Biol. 47: 569-580.
19. Hollstein, M., Sidransky, D., Vogelstein, B. and Harris, C. C. (1991) p53 mutations in human cancers. Science 253: 49-53.
20. Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B. and Craig, R. W. (1991) Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51: 6304-6311.
21. Kadhim, M. A., Walker, C. A., Plumb, M. A. and Wright, E. G. (1996) No association between p53 status and or-particle-induced chromosomal instability in human lymphoblastoid cells. Int. J. Radiat. Biol. 69: 167-174.
22. Kadhim, M. A., Lorimore, S. A., Townsend, K. M. S., Goodhead, D. T., Buckle, V. J. and Wright, E. G. (1995) Radiation-induced genomic instability: delayed cytogenetic aberrations and apoptosis in primary human bone marrow cells. Int. J. Radiat. Biol. 67: 287-293.
23. Ponnaiya, B., Limoli, C. L., Corcoran, J., Kaplan, M. L., Hartmann, A. and Morgan, W. F. (1998) The evolution of chromosomal instability in Chinese hamster cells: a changing picture? Int. J. Radiat. Biol. 74: 765-770.
24. Carrano, A. V., Minkler J. and Piluso, D. (1975) On the fate of stable chromosomal aberrations. Mutat. Res. 30: 153-156.
25. Sawyer, J. R., Roloson, G. J., Bell, J. M., Thomas, J. R., Teo, C. and Chadduck, W. M. (1996) Telomeric associations in the progression of chromosome aberrations in pediatric solid tumors. Cancer Genet. Cytogenet. 90: 1-13.
26. Kojis, T. L., Gatti, R. A. and Sparkes, R. S. (1991) The cytogenetics of ataxia telangiectasia. Cancer Genet. Cytogenet. 56: 143-156.
27. Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B. and Bacchetti, S. (1992) Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11: 1921-1929.
28. Kaplan, M. I., Limoli, C. L. and Morgan, W. F. (1997) Perpetuating radiation induced chromosomal instability. Radial. Oncol. Investig. 5: 124-128.
29. Lorimore, S. A., Kadhim, M. A., Pocock, D. A., Papworth, D., Stevens, D. L. and Goodhead, D. T. (1998) Chromosomal instability in the descendants of unirradiated surviving cells aller α-particle irradiation. Proc. Natl. Acad. Sci. USA 95: 5730-5733.
30. 238Pu alpha-particles. Carcinogenesis 17: 1671-1676.
31. Holmberg, K., Meijer A. E., Auer, G. and Lambert, B. O. (1995) Delayed chromosomal instability in human T-lymphocyte clone exposed to ionizing radiation. Int. J. Radiat. Biol. 68: 245-255.
32. Suzuki, K., Takahara, R., Kodama, S. and Watanabe, M. (1498) In situ detection of chromosome bridge formation and delayed reproductive death in normal human embryonic cells surviving X irradiation. Radiat. Res. 150: 375-381.