The contribution of 1H-magnetic resonance spectroscopy in defining the pathophysiology of multiple sclerosis

Italian Journal of Neurological Sciences

Volumn 20, Issue 5 SUPPL., 1999, Pages

  Simone, I L ^a   Tortorella, C ^a   Federico, F ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DIAGNOSTIC AGENT; PROTON;

BLOOD BRAIN BARRIER; BRAIN; DEMYELINATING DISEASE; ENCEPHALITIS; HUMAN; MULTIPLE SCLEROSIS; NERVE FIBER; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY; PATHOPHYSIOLOGY; REVIEW;

AXONS; BLOOD-BRAIN BARRIER; BRAIN; DEMYELINATING DISEASES; ENCEPHALITIS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MULTIPLE SCLEROSIS; PROTONS;

EID: 0033289839     PISSN: 03920461     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100729970004     Document Type: Article

References (49)

1. Young IR, Hall AS, Pallis CA et al ( 1981 ) Nuclear magnetic resonance imaging of the brain in multiple sclerosis. Lancet 2:1063-1066
2. Grossman RI, Gonzales-Scarano F, Atlas SW et al (1986) Multiple sclerosis: gadolinium enhancement in MR imaging. Radiology 161:721-725
3. Barkof F, Filippi M (1995) Can MRI be a predictor of long term clinical outcome for MS? Int Mult Scier J 2:4-9
4. van Walderveen MAA, Kamphorst W, Scheltens Pet al (1998) Histopathologic correlate of hypointense lesions on Tlweighted spin-echo MRI in multiple sclerosis. Neurology 50:1282-1288
5. Hiehle JF, Grossman RJ, Ramer KM, Gonzales-Scarano F, Cohen JA (1995) Magnetization transfer effects in MR-detected multiple sclerosis lesions: comparison with gadoliniumenhanced spin-echo images and nonenhanced T l-weighted images. AJNR Am J Neuroradiol 16:69-77
6. Loevner LA, Grossman RI, Mcgowan JC, Ramer KM, Cohen JA (1995) Characterization of multiple sclerosis plaques with TI-weighted MR and quantitative magnetization transfer. AJNR Am J Neuroradiol 16:1473-1479
7. van Walderveen MAA Barkhof F, Hommes OR et al (1995) Correlating MRI and clinical disease activity in multiple sclerosis: relevance of hypointense lesions on short-TR/short-TE (Tl-weighted) spin-echo images. Neurology 45:1684-1690
8. Brück W, Bitsch A, Kolenda H, Brück Y, Stiefel M, Lassmann H (1997) Inflammatory central nervous system demyelination: correlation of magnetic resonance imaging findings with lesion pathology. Ann Neurol 42:783-793
9. Davie CA, Barker GJ, Thompson AJ, Tofts PS, Me Donald WI, Miller DH (1997) 'H magnetic resonance spectroscopy of chronic cerebral white matter lesions and normal appearing white matter in multiple sclerosis. J Neurol Neurosurg Psychiatry 63:736-742
10. van der Walderveen MAA, Barkhof F, Powels PJW et al (1999) Neuronal damage in T l-hypointense multiple sclerosis lesions demonstrated in vivo using proton magnetic resonance spectroscopy. Ann Neurol 46:79-87
11. Posse S, Schuknecht B, Smith ME, van Zijl PCM, Herschkowitz N, Moonen CTW (1993) Short echo time proton MR spectroscopic imaging. J Comput Assist Tomogr 17:1-14
12. Soher BJ, van Zijl PCM, Duyn JH, Barker PB (1996) Quantitative proton MR spectroscopic imaging of the human brain. Magn Reson Med 35:356-363
13. Michaelis T, Merboldt KD, Bruhn H et al (1993) Absolute concentration of metabolites in the adult brain in vivo: quantification of localized proton MR spectra. Neuroradiology 187:219-227
14. Heterington HP, Pan JW, Mason GF et al (1996) Quantitative 'H spectroscopic imaging of human brain at 4. l T using image segmentation. Magn Reson Med 36:72-77
15. Sarchielli P, Presciutti O, Pelliccioli GP et al (1999) Absolute quantification of brain metabolites by proton magnetic resonance spectroscopy in normal appearing white matter of multiple sclerosis patients. Brain 122:513-521
16. McDonald WJ, Miller DH, Barnes D ( 1992) The pathological evolution of multiple sclerosis. Neuropathol Appl Neurobiol 18:319-334
17. Kermode AG, Tofts P, Thompson AJ et al ( 1990) Heterogeneity of blood-brain barrier changes in multiple sclerosis: an MRI study with Gd-DTPA enhancement. Neurology 40:229-235
18. Lopez-Villegas D, Lenkinski RE, Wehrli SL, Ho WZ, Douglas SD (1995) Lactate production by human monocytes/macrophages determined by proton MR spectroscopy. Magn Reson Med 34:32-38
19. Davie CA, Hawkins CP, Barker GJ et al (1994) Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain 117:49-58
20. Arnold DL, Matthews PM, Francis GS, O'Connor J, Antel JP (1992) Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques. Ann Neurol 31:235-241
21. De Stefane N, Mattews PM, Antel JP, Preul M, Francis P, Arnold DL (1995) Chemical pathology of acute demyelinating lesions and its correlation with disability. Ann Neurol 38:901-909
22. Brück W, Porada PH, Poser S et al (1995) Monocyte/ macrophage differentiation in early multiple sclerosis. Ann Neurol 38:788-796
23. Simone IL, Federico F, Trojano M et al (1996) High resolution proton MR-spectroscopy of cerebrospinal fluid in MS patients. Comparison with biochemical changes in demyelinating plaques. J Neurol Sei 144:182-190
24. Narayana PA, Doyle TJ, Lai D, Wolinsky JS (1998) Serial proton magnetic resonance spectroscopic imaging, contrastenhanced magnetic resonance imaging and quantitative lesion volumetry in multiple sclerosis. Ann Neurol 43:56-71
25. Adams CWM, Poston RN, Buk SJ (1989) Pathology, histochemistry and immunocytochemistry of lesions in acute multiple sclerosis. J Neurol Sei 92:291-306
26. Ferguson B, Matyszak MK, Esiri MM, Perry VH (1997) Axonal damage in acute multiple sclerosis lesions. Brain 120:393-399
27. Brück W, Bitsch A, Kolenda H, Brück Y, Stiefel M, Lassmann H (1997) Inflammatory central nervous system demyelination: correlation of magnetic resonance imaging findings with lesion pathology. Ann Neurol 42:783-793
28. Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mörk S, Bö L (1998) Axonal transection in the lesions of multiple sclerosis. N Engl J Med 338:278-285
29. Koo EH, Sisodia SS, Archer DR et al ( 1990) Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc Natl Acad Sei USA 87:1561-1565
30. De Stefano N, Matthews PM, Fu L et al (1998) Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study. Brain 121:1469-1477
31. Narayana PA, Doyle TJ, Lai D, Wolinsky JS (1998) Serial proton magnetic resonance spectroscopic imaging, contrastenhanced magnetic resonance imaging and quantitative lesion volumetry in multiple sclerosis. Ann Neurol 43:56-71
32. Simmons ML, Frondoza CG, Coyle JT (1991) Immunocytochemical localization of N-acetyl aspartate with monoclonal antibodies. Neuroscience 45:37-45
33. Davie CA, Barker GJ, Webb S et al (1995) Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axon loss. Brain 118:15831592
34. Patel TB, Clark JB (1979) Synthesis of /V-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial cytosolic carbon transport. Biochem J 184:539-546
35. Arstila AU, Riekkinen P, Rinne UK, Laitinen L (1973) Studies on the pathogenesis of multiple sclerosis. Participation of lysosomes on demyelination in the central nervous system white matter outside plaques. Eur Neurol 9:1-20
36. Adams CMW (1977) Pathology of multiple sclerosis: progression of the lesion. Br Med Bull 33:15-20
37. Alien IV, McKeown SR (1979) A histological, histochemical and biochemical study of the macroscopically normal white matter in multiple sclerosis. J Neurol Sei 41:81-91
38. Filippi M, Campi A, Dousset V et al (1995) A magnetization transfer imaging study of normal-appearing white matter in multiple sclerosis. Neurology 45:478-482
39. Filippi M, lannucci G, Tortorella C et al (1999) Comparison of MS clinical phenotypes using conventional and magnetization transfer MRI. Neurology 52:588-594
40. Gasperini C, Horsfield MA, Thorpe JW et al (1996) Macroscopic and microscopic assessments of disease burden by MRI in multiple sclerosis: relationship to clinical parameters. J Magn Reson Imaging 6:580-584
41. Horsfield MA, Lai M, Webb SL et al (1996) Apparent diffusion coefficient in benign and secondary progressive multiple sclerosis by nuclear magnetic resonance. Magn Reson Med 36:393-400
42. Davies SE, Newcombe J, Williams SR et al (1995) High resolution proton NMR spectroscopy of multiple sclerosis lesions. J Neurochem 64:742-748
43. Tourbah A, Stievenart JL, Gout O et al ( 1999) Localized proton magnetic resonance spectroscopy in relapsing remitting versus secondary progressive multiple sclerosis. Neurology 53:1091-1097
44. Busted CA, Goodkin DS, Huge JW et al (1994) Biochemical alterations in multiple sclerosis lesions and normal appearing white matter demonstrated by in vivo 3IP and 1H spectroscopic imaging. Ann Neurol 36:157-165
45. Rooney WD, Goodkin DE, Schuff N et al ( 1997) l H-MRSI of normal appearing white matter in multiple sclerosis. Mult Scier 3:231-237
46. Shiepers C, Van Hecke P, Vandenberghe R et al (1997) Positron emission tomography, magnetic resonance imaging and proton MR spectroscopy of white matter in multiple sclerosis. Mult Scler 3:8-17
47. Fu L, Matthews PM, De Stefano N, Worsley KJ et al (1998) Imaging of axonal damage of normal-appearing white matter in multiple sclerosis. Brain 121:103-113
48. Ormerod IE et al (1986) Relaxation times of apparently normal cerebral white matter in multiple sclerosis. Acta Radiol Suppl (Stockh) 396:382-384
49. Brex PA, Gomez-Anson B, Parker GJ et al ( 1999) Proton MR spectroscopy in clinically isolated syndromes suggestive of multiple sclerosis. J Neurol Sei 166:16-22