Nature's universal oxygenases: The cytochromes P450

Essays in Biochemistry

Volumn 34, Issue , 1999, Pages 71-83

  Sligar, Stephen G ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; OXYGEN;

ANIMAL; CHEMICAL MODEL; CHEMISTRY; CLASSIFICATION; HUMAN; METABOLISM; REVIEW;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MODELS, CHEMICAL; OXYGEN;

EID: 0033287587     PISSN: 00711365     EISSN: None     Source Type: Journal    
DOI: 10.1042/bse0340071     Document Type: Article

References (23)

1. Ramm, P.J. & Caspi, E. (1969) The stereochemistry of tritium atoms 1, 7 and 15 in cholesterol derived from (3R,2R)-(2-3H)-mevalonic acid. J. Biol. Chem. 244, 6064-6073
2. Garfinkel, D. (1958) Preparation and properties of a microsomal reduced diphosphopyridine nucleotide - cytochrome c reductase. Arch. Biochem. Biophys. 77, 493-509
3. Klingenberg, M. (1958) Pigments of liver microsomes. Arch. Biochem. Biophys. 75, 376-386
4. Hanson, L.K., Eaton, W.A., Sligar, S.G., Gunsalus, I.C., Gouterman, M. & Connell, C.R. (1976) Letter: Origin of the anomalous Soret spectra of carboxycytochrome P-450. J. Am. Chem. Soc. 98, 2672-2674
5. Mason, H.S., North, J.C. & Vanneste, M. (1965) Microsomal mixed-function oxidations: the metabolism of xenobiotics. Fed. Proc. Fed. Am. Soc. Exp. Biol. 24, 1172-1180
6. Champion, P.M., Stallard, B.R., Wagner, G.C. & Gunsalus, I.C. (1982) Resonance Raman detection of an iron-sulphur bond in cytochrome P450cam. J. Am. Chem. Soc. 104, 5469-5472
7. Poulos, T.L., Finzel, B.C. & Howard, A.J. (1987) High-resolution crystal structure of cytochrome P450cam. J. Mol. Biol. 195, 687-700
8. Dawson, J.H., Andersson, L.A. & Sono, M. (1982) Spectroscopic investigations of ferric cytochrome P-450-cam ligand complexes. Identification of the ligand trans to cysteinate in the native enzyme. J. Biol. Chem. 257, 3606-3617
9. Cooper, D.Y., Levin, S., Narasimhulu, S., Rosenthal, O. & Estabrook, R.W. (1965) Photochemical action spectra of the terminal oxidase of mixed function oxidase systems. Science 147, 400-402
10. Lu, A. & Coon, M.J. (1968) Role of hemoprotein P-450 in fatty acid omega-hydroxylation in a soluble enzyme system from liver microsomes. J. Biol. Chem. 243, 1331-1332
11. Hedegaard, J. & Gunsalus, I.C. (1965) Mixed function oxidation. IV. An induced methylene hydroxylase in camphor oxidation. J. Biol. Chem. 240, 4038-4043
12. Olsen, G.T. & Woese, C.R. (1997) Archaeal genomics: an overview. Cell 89, 991-994
13. Gutell, R.R., Larsen, N. & Woese, C.R. (1994) Lessons from an evolving rRNA: 16 S and 23 S rRNA structures from a comparative perspective. Microbiol. Rev. 58, 10-26
14. Shumada, H., Sligar, S.G., Yeom, H. & Ishimura, Y. (1996) Heme monooxygenases. A chemical mechanism for cytochrome P450 oxygen activation, in Oxygenoses and Model Systems (Funabiki, T., ed.), pp. 195-221, Kluwer Academic Publishers, Hingham, MA
15. Martinis, S.A., Atkins, W.M., Stayton, P.S. & Sligar, S.G. (1989) A conserved residue of cytochrome P-450 is involved in heme-oxygen stability and activation. J. Am Chem. Soc. 111, 9252-9253
16. Groves, J.T. (1985) Key elements of the chemistry of cytochrome P450. The oxygen rebound mechanism. J. Chem. Educ. 62, 928-931
17. Collman, J.P., Chien, A.S., Eberspacher, T.A. & Brauman, J.I. (1998) An agostic alternative to the P-450 rebound mechanism. J. Am Chem. Soc 120, 425-426
18. Yoshizawa, K. (1998) Two-step concerted mechanism for alkane hydroxylation on the ferryl active site of methane monooxygenase. J. Inorg. Biol. Chem. 3, 318-324
19. Coon, M.J., Vaz, A.D.N., McGinnity, D.F. & Peng, H.-M. (1998) Multiple activated oxygen species in P450 catalysis: contributions to specificity in drug metabolism. Drug Metab. Disp. 26, 1190-1193
20. Newcomb, M., Le Tadic-Biadatti, M.H., Chestney, D.L., Roberts, E.S. & Hollenberg, P.F. (1995) A nonsynchronous concerted mechanism for cytochrome-P450 catalysed hydroxylation. J. Am. Chem. Soc. 117, 12085-12091
21. Ortiz de Montellano, P.R. (ed.) (1995) Cytochrome P450: Structure, Mechanism and Biochemistry, 2nd edn., Plenum, New York
22. Gray, H.B. & Winkler, J.R. (1996) Electron transfer in proteins. Annu. Rev. Biochem. 65, 537-561
23. Moser, C.C. & Dutton, P.L. (1996) Outline of theory of protein electron transfer. In Protein Electron Transfer (Bendal, D.S., ed.), pp. 1-21. BIOS Scientific Publishers, Oxford