The protective role of 11β-hydroxysteroid dehydrogenase/carbonyl reductase against tobacco-smoke related lung cancer

Advances in Experimental Medicine and Biology

Volumn 463, Issue , 1999, Pages 379-387

  Maser, E ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; ANTIBODY; CARBONYL REDUCTASE; GLUCOCORTICOID; GLYCYRRHETINIC ACID; TOBACCO SMOKE;

CONFERENCE PAPER; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME PURIFICATION; LUNG CANCER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

NICOTIANA TABACUM;

EID: 0033282016     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-4735-8_47     Document Type: Conference Paper

References (31)

1. On the pharmacokinetics of tobacco-specific N-nitrosamines in Fisher rats
2. Pharmacokinetics of N-nitrosonornicotine and 4-methylnitrosamino-1-(3-pyridyl)-1-butanone in laboratory animals
3. Cancer Statistics, 1994
4. Changes in chemical composition of Burley tobacco during senescence and curing. 3. Tobacco specific nitrosamines
5. Intraindividual and interindividual differences in metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smoker's urine
6. Analysis of human urine for pyridine-N-oxide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific lung carcinogen
7. A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6
8. Metabolic activation and detoxification of tobacco-specific nitrosamines - A model for cancer prevention strategies
9. A tobacco specific lung carcinogen in the urine of men exposed to cigarette smoke
10. Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke
11. The relevance of tobacco-specific nitrosamines to human cancer
12. Metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the patas monkey: Pharmacokinetics and characterization of glucuronide metabolites
13. Metabolism in the F344 rat of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen
14. Xenobiotic carbonyl reduction and physiological steroid oxidoreduction - The pluripotency of several hydroxysteroid dehydrogenases
15. 11β-Hydroxysteroid dehydrogenase acts as carbonyl reductase in microsomal phase 1 drug metabolism
16. Stress, hormonal changes, alcohol, food constituents and drugs: Factors that advance the incidence of tobacco smoke-related cancer?
17. 11β-Hydroxysteroid dehydrogenase responsible for carbonyl reduction of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes
18. The purification of 11β-hydroxysteroid dehydrogenase from mouse liver microsomes
19. 11β-Hydroxysteroid dehydrogenase mediates reductive metabolism of xenobiotic carbonyl compounds
20. Ontogenic pattern of carbonyl reductase activity of 11β-hydroxysteroid dehydrogenase in mouse liver and kidney
21. Role of type-1 11β-hydroxysteroid dehydrogenase in detoxification processes
22. The identification of 11 beta-hydroxysteroid dehydrogenase as carbonyl reductase of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
23. Metabolites of 4-(N-methylnitrosamino)-1-(3-pyridyl)-1-butanone in urine of smokers
24. Dose-response study of DNA and hemoglobin adduct formation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats
25. Cloning and primary structure of murine 11β-hydroxysteroid dehydrogenase/microsomal carbonyl reductase
26. Biotransformation and detoxification of insecticidal metyrapone analogues by carbonyl reduction in the human liver
27. Acute reduction of renal 11 beta-hydroxysteroid dehydrogenase activity by several antinatriuretic stimuli
28. Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines
29. 11β-Hydroxysteroid dehydrogenase isoforms and their implications for blood pressure regulation
30. Alcohol inhibits 11-beta-hydroxysteroid dehydrogenase activity in rat kidney and liver
31. Smoking and lung cancer: Scientific challenges and opportunities