Analysis of human urine for pyridine-N-oxide metabolites of 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific lung carcinogen

Cancer Epidemiology Biomarkers and Prevention

Volumn 6, Issue 2, 1997, Pages 113-120

  Carmella, Steven G ^a   Borukhova, Anna ^a   Akerkar, Shobha A ^a   Hecht, Stephen S ^a,b  

^a AMERICAN HEALTH FOUNDATION   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; PYRIDINE 1 OXIDE;

ARTICLE; CANCER RISK; CHEMICAL CARCINOGENESIS; HUMAN; LUNG CANCER; PRIORITY JOURNAL; SMOKING; TOBACCO; URINE LEVEL;

ANTICARCINOGENIC AGENTS; BIOLOGICAL MARKERS; BIOTRANSFORMATION; CARCINOGENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COTININE; CREATININE; ENZYME INHIBITORS; GLUCURONATES; HUMANS; ISOTHIOCYANATES; LUNG NEOPLASMS; MASS SPECTROMETRY; METABOLIC DETOXICATION, DRUG; NICOTINE; NITROSAMINES; PROTEUS MIRABILIS; PYRIDINES;

EID: 0031026558     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Hoffmann, D., and Hecht, S. S. Advances in tobacco carcinogenesis. In: C. S. Cooper and P. L. Grover (eds.). Handbook of Experimental Pharmacology, pp. 63-102. Heidelberg: Springer-Verlag, 1990.
2. Hecht, S.S., and Hoffmann, D. The relevance of tobacco-specific nitrosamines to human cancer. Cancer Surv., 8: 273-294, 1989.
3. Hecht, S. S., and Hoffmann, D. Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke. Carcinogenesis (Lond.), 9: 875-884, 1988.
4. Hoffmann, D., Rivenson, A., and Hecht, S. S. Carcinogenesis of smokeless tobacco. In: Smokeless Tobacco or Health. An International Perspective. Smoking Tobacco Control Monograph, 2: 109-118, 1992.
5. Hecht, S.S. Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen. CRC Crit. Rev. Toxicol., 26: 163-181, 1996.