Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2 both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity

American Journal of Respiratory Cell and Molecular Biology

Volumn 21, Issue 6, 1999, Pages 701-709

  Fernandes, Audrey M ^b   Hamburger, Anne W ^b   Gerwin, Brenda I ^a  

^a Laboratory of Human Carcinogenesis   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL; ARTICLE; CELL LINE; CELL TRANSFORMATION; DIMERIZATION; EPITHELIUM CELL; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; LUNG; METABOLISM; MOUSE; NUDE MOUSE; PROTEIN BINDING; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; DIMERIZATION; EPITHELIAL CELLS; FLOW CYTOMETRY; HUMANS; LUNG; MICE; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN BINDING; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECEPTOR, ERBB-3; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0033257956     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.21.6.3784     Document Type: Article

References (33)

1. Wilks, A. F. 1993. Protein tyrosine kinase growth factor receptors and their ligands in development, differentiation, and cancer. Adv. Cancer Res. 60: 43-73.
2. Kern, J. A., D. Schwartz, J. A. Nordberg, D. B. Weiner, M. I. Greene, L. Torney, and R. A. Robinson. 1990. p185neu expression in human lung adenocarcinomas predicts shortened survival. Cancer Res. 50:5184-5191.
3. Dittadi, R., M. Gion, V. Pagan, A. Brazzale, O. Del Maschio, A. Bargossi, A. Busetto, and G. Bruscagnin. 1991. Epidermal growth factor receptor in lung malignancies: comparison between cancer and normal tissue. Br. J. Cancer 64:741-744.
4. Salomon, D. S., R. Brandt, F. Ciardiello, and N. Normanno. 1995. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit. Rev. Oncol. Hematol. 19:183-232.
5. Di Fiore, P. P., J. H. Pierce, T. P. Fleming, R. Hazan, A. Ullrich, C. R. King, J. Schlessinger, and S. A. Aaronson. 1987. Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells. Cell 51:1063-1070.
6. Pierce, J. H., P. Arnstein, E. DiMarco, J. Artrip. M. H. Kraus, F. Lonardo, P. P. Di Fiore, and S. A. Aaronson. 1991. Oncogenic potential of erbB-2 in human mammary epithelial cells. Oncogene 6:1189-1194.
7. Noguchi, M., M. Murakami, W. Bennett, R. Lupu, F. Hui, Jr., C. C. Harris, and B. I. Gerwin. 1993. Biological consequences of overexpression of a transfected c-erbB-2 gene in immortalized human bronchial epithelial cells. Cancer Res. 53:2035-2043.
8. Kokai, Y., J. N. Myers, T. Wada, V. I. Brown, C. M. LeVea, J. G. Davis, K. Dobashi, and M. I. Greene. 1989. Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts. Cell 58: 287-292.
9. Oian, X., C. M. LeVea, J. K. Freeman, W. C. Dougall, and M. I. Greene. 1994. Heterodimerization of epidermal growth factor receptor and wildtype or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation. Proc. Natl. Acad. Sci. USA 91:1500-1504.
10. Muller, W. J., C. L. Arteaga, S. K. Muthuswamy, P. M. Siegel, M. A. Webster, R. D. Cardiff, K. S. Meise, F. Li, S. A. Halter, and R. J. Coffey. 1996. Synergistic interaction of the Neu proto-oncogene product and transforming growth factor alpha in the mammary epithelium of transgenic mice. Mol. Cell. Biol. 16:5726-5736.
11. Alroy, I., and Y. Yarden. 1997. The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions. FEBS Lett. 410:83-86.
12. King, C. R., I. Borrello, F. Bellot, P. Comoglio, and J. Schlessinger. 1988. Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3. EMBO J. 7:1647-1651.
13. Olayioye, M. A., D. Graus-Porta, R. R. Beerli, J. Rohrer, B. Gay, and N. E. Hynes. 1998. ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner. Mol. Cell. Biol. 18:5042-5051.
14. Hamburger, A. W., A. Fernandes, M. Murakami, and B. I. Gerwin. 1998. The role of transforming growth factor alpha production and ErbB-2 overexpression in induction of tumorigenicity of lung epithelial cells. Br. J. Cancer 77:1066-1071.
15. Fernandes, A. M., A. W. Hamburger, and B. I. Gerwin. 1999. Production of epidermal growth factor related ligands in tumorigenic and benign lung epithelial cells. Cancer Lett. 142:55-63.
16. Reddel, R. R., Y. Ke, B. I. Gerwin, M. G. McMenamin, J. F. Lechner, R. T. Su, D. E. Brash, J. B. Park, J. S. Rhim, and C. C. Harris. 1988. Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes. Cancer Res. 48:1904-1909.
17. Beerli, R. R., W. Wels, and N. E. Hynes. 1994. Intracellular expression of single chain antibodies reverts ErbB-2 transformation. J. Biol. Chem. 269: 23931-23936.
18. Beerli, R. R., W. Wels, and N. E. Hynes. 1994. Autocrine inhibition of the epidermal growth factor receptor by intracellular expression of a single-chain antibody. Biochem. Biophys. Res. Commun. 204:666-672.
19. Wels, W., I. M. Harwerth, M. Zwickl, N. Hardman, B. Groner, and N. E. Hynes. 1992. Construction, bacterial expression and characterization of a bifunctional single-chain antibody-phosphatase fusion protein targeted to the human erbB-2 receptor. Biotechnology 10:1128-1132.
20. Bestwick, R. K., S. L. Kozak, and D. Kabat. 1988. Overcoming interference to retroviral superinfection results in amplified expression and transmission of cloned genes. Proc. Natl. Acad. Sci. USA 85:5404-5408.
21. Riese, D. J., II, T. M. van Raaij, G. D. Plowman, G. C. Andrews, and D. F. Stern. 1995. The cellular response to neuregulins is governed by complex interactions of the erbB receptor family Mol. Cell. Biol. 15:5770-5776. (Published erratum appears in Mol. Cell. Biol. 1996;16:735.)
22. Tzahar, E., H. Waterman, X. Chen, G. Levkowitz, D. Karunagaran, S. Lavi, B. J. Ratzkin, and Y. Yarden. 1996. A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. Mol. Cell. Biol. 16:5276-5287.
23. Ben-Baruch, N., and Y. Yarden. 1994. Neu differentiation factors: a family of alternatively spliced neuronal and mesenchymal factors. Proc. Soc. Exp. Biol. Med. 206:221-227.
24. Gamett, D. C., G. Pearson, R. A. Cerione, and I. Friedberg. 1997. Secondary dimerization between members of the epidermal growth factor receptor family. J. Biol. Chem. 272:12052-12056.
25. Beerli, R. R., and N. E. Hynes. 1996. Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities. J. Biol. Chem. 271:6071-6076.
26. Graus-Porta, D., R. R. Beerli, J. M. Daly, and N. E. Hynes. 1997. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J. 16:1647-1655.
27. Karunagaran, D., E. Tzahar, R. R. Beerli, X. Chen, D. Graus-Porta, B. J. Ratzkin, R. Seger, N. E. Hynes, and Y. Yarden. 1996. ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. EMBO J. 15:254-264.
28. Tsao, M. S., H. Zhu, and J. Viallet. 1996. Autocrine growth loop of the epidermal growth factor receptor in normal and immortalized human bronchial epithelial cells. Exp. Cell Res. 223:268-273.
29. Pinkas-Kramarski, R., A. E. Lenferink, S. S. Bacus, L. Lyass, M. L. van de Poll, L. N. Klapper, E. Tzahar, M. Sela, E. J. van Zoelen, and Y. Yarden. 1998. The oncogenic ErbB-2/ErbB-3 heterodimer is a surrogate receptor of the epidermal growth factor and betacellulin. Oncogene 16:1249-1258.
30. Lenferink, A. E., A. D. De Roos, M. J. Van Vugt, M. L. van de Poll, and E. J. van Zoelen. 1998. The linear C-terminal regions of epidermal growth factor (EGF) and transforming growth factor-alpha bind to different epitopes on the human EGF receptor. Biochem. J. 336:147-151.
31. Waterman, H., I. Sabanai, B. Geiger, and Y. Yarden. 1998. Alternative intracellular routing of ErbB receptors may determine signaling potency. J. Biol. Chem. 273:13819-13827.
32. Lenferink, A. E., R. Pinkas-Kramarski, M. L. van de Poll, M. J. Van Vugt, L. N. Klapper, E. Tzahar, H. Waterman, M. Sela, E. J. van Zoelen, and Y. Yarden. 1998. Differential endocytic routing of homo-and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers. EMBO J. 17:3385-3397.
33. Worthylake, R., L. K. Opresko, and H. S. Wiley. 1999. ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors. J. Biol. Chem. 274:8865-8874.