Selective inhibition of neuronal nitric oxide synthase fails to alter the resting tension and the relaxant effect of bradykinin in isolated rat middle cerebral arteries

Acta Physiologica Hungarica

Volumn 86, Issue 2, 1999, Pages 161-165

  Benyó, Zoltán ^a,b   Lacza, Zs ^a,b   Gorlach Ch ^a   Wahl, M ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

Author keywords

7 nitro indazole monosodium salt; Bradykinin; Endothelium; Neuronal nitric oxide synthase; Rat middle cerebral artery

Indexed keywords

7 NITROINDAZOLE; 7-NITROINDAZOLE; BRADYKININ; ENZYME INHIBITOR; INDAZOLE DERIVATIVE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; NOS1 PROTEIN, RAT; URIDINE TRIPHOSPHATE;

ANIMAL; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; IN VITRO STUDY; MALE; MIDDLE CEREBRAL ARTERY; MUSCLE TONE; RAT; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; VASODILATATION; WISTAR RAT;

ANIMALS; BRADYKININ; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; INDAZOLES; MALE; MIDDLE CEREBRAL ARTERY; MUSCLE TONUS; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; RATS; RATS, WISTAR; URIDINE TRIPHOSPHATE; VASOCONSTRICTION; VASODILATION;

EID: 0033254268     PISSN: 0231424X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Benyó, Z., Görlach, C., Wahl, M.: Neuronal nitric oxide synthase is involved in agonist-induced but not in basal nitric oxide release in isolated rat basilar arteries. J. Cereb. Blood Flow Metab., 17 (Suppl 1), S345 (1997).
2. 2 in the mediation of the contractile effect induced by inhibition of nitric oxide synthesis in isolated rat middle cerebral arteries. J. Cereb. Blood Flow Metab., 18, 616-618 (1998).
3. Bredt, D. S., Hwang, P. M., Snyder, S. H.: Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature, 347, 768-770 (1990).
4. Faraci F., Heistad, D. D.: Regulation of the cerebral circulation: Role of endothelium and potassium channels. Physiol. Rev., 78, 53-97 (1998).
5. Gorelova, E., Loesch, A., Bodin, P., Chadwick, L., Hamlyn, P. J., Burnstock, G.: Localisation of immunoreactive factor VIII, nitric oxide synthase, substance P, endothelin-1 and 5-hydroxytriptamine in human postmortem middle cerebral artery. J. Anat., 188, 97-107 (1996).
6. 2 receptors and release of nitric oxide. Peptides, 17, 1373-1378 (1996).
7. Hudetz, A. G., Shen, H., Kampine, J. P.: Nitric oxide from neuronal NOS plays a critical role in cerebral capillary flow response to hypoxia. Am. J. Physiol., 274, H982-H989 (1998).
8. Iadecola, C., Pelligrino, D. A., Moskowitz, M. A., Lassen, N. A.: Nitric oxide synthase inhibition and cerebrovascular regulation. J. Cereb. Blood Flow Metab., 14, 175-192 (1994).
9. Kelly, P. A. T., Ritchie, I. M., Arbuthnott, G. W.: Inhibition of neuronal nitric oxide synthase by 7-nitroindazole: effects upon local cerebral blood flow and glucose use in the rat. J. Cereb. Blood Flow Metab., 15, 766-773 (1995).
10. Kovách, A. G. B., Lohinai, Z., Marczis, J., Balla, I., Dawson, T. M., Snyder, S. H.: The effect of hemorrhagic hypotension and retransfusion and 7-nitro-indazole on rCBF, NOS catalytic activity, and cortical NO content in the cat. Ann. NY Acad. Sci., 738, 348-368 (1994).
11. Nozaki, K., Moskowitz, M. A., Maynard, K. I., Koketsu, N., Dawson, T. M., Bredt, D. S., Snyder, S. H.: Possible origins and distribution of immunoreactive nitric oxide synthase-containing nerve fibers in cerebral arteries. J. Cereb. Blood Flow Metab., 13, 70-79 (1993).
12. Okamoto, H., Hudetz, A. G., Roman, R. J., Bosnjak, Z. J., Kampine, J. P.: Neuronal NOS-derived NO plays permissive role in cerebral blood flow response to hypercapnia. Am. J. Physiol., 272, H559-H566 (1997).
13. Silva, M. T., Rose, S., Hindmarsh, J. G., Aislaitner, G., Gorrod, J. W., Moore, P. K., Jenner, P., Marsden, C. D.: Increased striatal dopamine efflux in vivo following inhibition of cerebral nitric oxide synthase by the novel monosodium salt of 7-nitro indazole. Br. J. Pharmacol., 114, 257-258 (1995).
14. Wahl, M., Görlach, C., Hortobágyi, T., Benyó, Z.: Effects of bradykinin in the cerebral circulation. Acta. Physiol. Hung., 86, 155-160 (1999).
15. Wang, Q., Pelligrino, D. A., Baughman, V. L., Koenig, H. M., Albrecht, R. F.: The role of neuronal nitric oxide synthase in regulation of cerebral blood flow in normocapnia and hypercapnia in rats. J. Cereb. Blood Flow Metab., 15, 774-778 (1995).
16. Zagvazdin, Y., Sancesario, G., Wang, Y. X., Share, L., Fitzgerald, M. E., Reiner, A.: Evidence from its cardiovascular effects that 7-nitroindazole may inhibit endothelial nitric oxide synthase in vivo. Eur. J. Pharmacol., 303, 61-69 (1996).