Chemistry of oligonucleotide-gold nanoparticle conjugates

Phosphorus, Sulfur and Silicon and Related Elements

Volumn 144-146, Issue , 1999, Pages 359-362

  Letsinger, Robert L ^a   Mirkin, Chad A ^a   Elghanian, Robert ^a   Mucic, Robert C ^a   Storhoff, James J ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Gold; Hybridization; Nanoparticles; Non radioactive detection; Oligonucleotide

Indexed keywords

EID: 0033234617     PISSN: 10426507     EISSN: None     Source Type: Journal    
DOI: 10.1080/10426509908546255     Document Type: Article

References (13)

1. S. Garzon and M. Bendayan, in Immuno-Gold Electron Microscopy, edited by A. D. Hyalt and B. T. Eaton, (CRC Press, Boca Raton, 1993) Chap. 6, p. 137.
2. M. A. Hayat, Colloidal Gold, Principles, Methods, and Applications, Vol.1(Academic Press, Inc. San Diego, 1989), p.1.
3. L. B. Bangs, Pure Appl. Chem., 68, 1873 (1996).
4. J. J. Storhoff, R. C. Mucic, and C. A. Mirkin, J. Cluster Sci. 8, 179 (1997).
5. C. R. Martin and D. T. Mitchell, Anal. Chem. News & Features, 322A (1998).
6. G. Frens, Nature Phys. Sci. 241, 20 (1973).
7. Use of thiol groups to link organic fragments to gold surfaces is well established. See, e.g., L. H. DuBois and R. G. Nuzzo, A. Rev. Phys. Chem., 43, 437 (1992) and C.S. Weisbecker, M. V. Merritt, and G. M. Whitesides, Langmuir, 12, 3763 (1996). For attachment of nucleotides through a terminal sulfur atom to gold, see R. C. Mucic, M. K. Herrlein, C. A. Mirkin, and R. L. Letsinger, Chem. Commun., 555 (1996). For a report of an alternate means for attaching an oligonucleotide to a nanoparticle see A. P. Alivisatos, K. P. Johnsson, X. Peng, T. E. Wilson, C. J. Loweth, M. P. Bruchez Jr, and P. G. Schultz, Nature, 382, 609 (1996).
8. Use of thiol groups to link organic fragments to gold surfaces is well established. See, e.g., L. H. DuBois and R. G. Nuzzo, A. Rev. Phys. Chem., 43, 437 (1992) and C.S. Weisbecker, M. V. Merritt, and G. M. Whitesides, Langmuir, 12, 3763 (1996). For attachment of nucleotides through a terminal sulfur atom to gold, see R. C. Mucic, M. K. Herrlein, C. A. Mirkin, and R. L. Letsinger, Chem. Commun., 555 (1996). For a report of an alternate means for attaching an oligonucleotide to a nanoparticle see A. P. Alivisatos, K. P. Johnsson, X. Peng, T. E. Wilson, C. J. Loweth, M. P. Bruchez Jr, and P. G. Schultz, Nature, 382, 609 (1996).
9. Use of thiol groups to link organic fragments to gold surfaces is well established. See, e.g., L. H. DuBois and R. G. Nuzzo, A. Rev. Phys. Chem., 43, 437 (1992) and C.S. Weisbecker, M. V. Merritt, and G. M. Whitesides, Langmuir, 12, 3763 (1996). For attachment of nucleotides through a terminal sulfur atom to gold, see R. C. Mucic, M. K. Herrlein, C. A. Mirkin, and R. L. Letsinger, Chem. Commun., 555 (1996). For a report of an alternate means for attaching an oligonucleotide to a nanoparticle see A. P. Alivisatos, K. P. Johnsson, X. Peng, T. E. Wilson, C. J. Loweth, M. P. Bruchez Jr, and P. G. Schultz, Nature, 382, 609 (1996).
10. Use of thiol groups to link organic fragments to gold surfaces is well established. See, e.g., L. H. DuBois and R. G. Nuzzo, A. Rev. Phys. Chem., 43, 437 (1992) and C.S. Weisbecker, M. V. Merritt, and G. M. Whitesides, Langmuir, 12, 3763 (1996). For attachment of nucleotides through a terminal sulfur atom to gold, see R. C. Mucic, M. K. Herrlein, C. A. Mirkin, and R. L. Letsinger, Chem. Commun., 555 (1996). For a report of an alternate means for attaching an oligonucleotide to a nanoparticle see A. P. Alivisatos, K. P. Johnsson, X. Peng, T. E. Wilson, C. J. Loweth, M. P. Bruchez Jr, and P. G. Schultz, Nature, 382, 609 (1996).
11. C. A. Mirkin, R. L. Letsinger, R. C. Mucic and J. J. Storhoff, Nature, 382, 607 (1996).
12. R. Elghanian, J. J. Storhoff, R. C. Mucic, R. L. Letsinger, and C. A. Mirkin, Science, 277, 1078 (1997).
13. J. J. Storhoff, R. Elghanian, R. C. Mucic, C. A. Mirkin, and R. L. Letsinger, J. Am. Chem. Soc., 120, 1959 (1998).