메뉴 건너뛰기




Volumn 49, Issue 2, 1996, Pages 185-196

Improvement of antibiotic titers from Streptomyces bacteria by interactive continuous selection

Author keywords

continuous culture; feedback control; strain improvement; streptomyces; streptomycin

Indexed keywords

ANTIBIOTICS; BACTERIA; CONTINUOUS CELL CULTURE; FEEDBACK CONTROL; GROWTH KINETICS; METABOLITES;

EID: 0030058922     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19960120)49:2<185::AID-BIT7>3.0.CO;2-M     Document Type: Article
Times cited : (42)

References (42)
  • 1
    • 0025895183 scopus 로고
    • Toward a science of metabolic engineering
    • Bailey, J. E. 1991. Toward a science of metabolic engineering. Science 252: 1668-1675.
    • (1991) Science , vol.252 , pp. 1668-1675
    • Bailey, J.E.1
  • 2
    • 0021889788 scopus 로고
    • Phenotypic changes associated with loss of expression of tylosin biosynthesis and resistance genes in Streptomyces fradiae
    • Baltz, R. H., Stonesifer, J. 1985. Phenotypic changes associated with loss of expression of tylosin biosynthesis and resistance genes in Streptomyces fradiae. J. Antibiot. 38: 1226-1236.
    • (1985) J. Antibiot. , vol.38 , pp. 1226-1236
    • Baltz, R.H.1    Stonesifer, J.2
  • 3
    • 0024259924 scopus 로고
    • Role of the carbon source in regulating chloramphenicol production by Streptomyces venezuelae: Studies in batch and continuous cultures
    • Bhatnagar, R. K., Doull, J. L., Vining, L. C. 1988. Role of the carbon source in regulating chloramphenicol production by Streptomyces venezuelae: Studies in batch and continuous cultures. Can. J. Microbiol. 34: 1217-1223.
    • (1988) Can. J. Microbiol. , vol.34 , pp. 1217-1223
    • Bhatnagar, R.K.1    Doull, J.L.2    Vining, L.C.3
  • 4
    • 0020412748 scopus 로고
    • Isolation of ethanol-tolerant mutants of yeast by continuous selection
    • Brown, S. W., Oliver, S. G. 1982. Isolation of ethanol-tolerant mutants of yeast by continuous selection. Eur. J. Appl. Microbiol. Biotechnol. 16: 119-122.
    • (1982) Eur. J. Appl. Microbiol. Biotechnol. , vol.16 , pp. 119-122
    • Brown, S.W.1    Oliver, S.G.2
  • 5
    • 0022100667 scopus 로고
    • Resistance, regulatory and production genes for the antibiotic methylenomycin are clustered
    • Chater, K. F., Bruton, C. J. 1985. Resistance, regulatory and production genes for the antibiotic methylenomycin are clustered. EMBO J. 4: 1893-1897.
    • (1985) EMBO J. , vol.4 , pp. 1893-1897
    • Chater, K.F.1    Bruton, C.J.2
  • 6
    • 0024458910 scopus 로고
    • Binding-protein-dependent sugar-transport by Agrobacterium radiobacter and Agrobacterium tumefaciens grown in continuous culture
    • Cornish, A., Greenwood, J. A., Jones, C. W. 1989. Binding-protein-dependent sugar-transport by Agrobacterium radiobacter and Agrobacterium tumefaciens grown in continuous culture. J. Gen. Microbiol. 135: 3001-3013.
    • (1989) J. Gen. Microbiol. , vol.135 , pp. 3001-3013
    • Cornish, A.1    Greenwood, J.A.2    Jones, C.W.3
  • 7
    • 0022643177 scopus 로고
    • Increased production of aminoglycosides associated with amplified antibiotic resistance genes
    • Crameri, R., Davies, J. E. 1986. Increased production of aminoglycosides associated with amplified antibiotic resistance genes. J. Antibiot. 29: 128-135.
    • (1986) J. Antibiot. , vol.29 , pp. 128-135
    • Crameri, R.1    Davies, J.E.2
  • 10
    • 0024459873 scopus 로고
    • How antibiotic-producing organisms avoid suicide
    • Cundliffe, E. 1989. How antibiotic-producing organisms avoid suicide. Annu. Rev. Microbiol. 43: 207-233.
    • (1989) Annu. Rev. Microbiol. , vol.43 , pp. 207-233
    • Cundliffe, E.1
  • 11
    • 0016138827 scopus 로고
    • How do antibiotic-producing organisms avoid suicide?
    • Demain, A. L. 1974. How do antibiotic-producing organisms avoid suicide? Ann. NY Acad. Sci. 235: 601-612.
    • (1974) Ann. NY Acad. Sci. , vol.235 , pp. 601-612
    • Demain, A.L.1
  • 12
    • 0023355091 scopus 로고
    • Gene cluster for streptomycin biosynthesis in Streptomyces griseus: Analysis of a central region including major resistance gene
    • Distler, J., Braun, C., Ebert, A., Piepersberg, W. 1987. Gene cluster for streptomycin biosynthesis in Streptomyces griseus: Analysis of a central region including major resistance gene. Mol. Gen. Genet. 208: 204.
    • (1987) Mol. Gen. Genet. , vol.208 , pp. 204
    • Distler, J.1    Braun, C.2    Ebert, A.3    Piepersberg, W.4
  • 13
    • 0000139226 scopus 로고
    • Evolution of competitive ability in Escherichia coli
    • Dykhuizen, D., Hartl, D. 1981. Evolution of competitive ability in Escherichia coli. Evolution 35: 15-16.
    • (1981) Evolution , vol.35 , pp. 15-16
    • Dykhuizen, D.1    Hartl, D.2
  • 15
    • 0023766395 scopus 로고
    • The isolation of strains of Bacillus subtilis showing improved plasmid stability characteristics by means of selective chemostat culture
    • Fleming, G., Dawson, M. T., Patching, J. W. 1988. The isolation of strains of Bacillus subtilis showing improved plasmid stability characteristics by means of selective chemostat culture. J. Gen. Microbiol. 134: 2095-2101.
    • (1988) J. Gen. Microbiol. , vol.134 , pp. 2095-2101
    • Fleming, G.1    Dawson, M.T.2    Patching, J.W.3
  • 17
    • 0019123754 scopus 로고
    • Production of the macrolide antibiotic tylosin in batch and chemostat cultures
    • Gray, P. P., Bhuwapathanapun, S. 1980. Production of the macrolide antibiotic tylosin in batch and chemostat cultures. Biotechnol. Bioeng. 22: 1785-1804.
    • (1980) Biotechnol. Bioeng. , vol.22 , pp. 1785-1804
    • Gray, P.P.1    Bhuwapathanapun, S.2
  • 18
    • 0019997456 scopus 로고
    • Mutants blocked in streptomycin production in Streptomyces griseus the role of A-factor
    • Hara, O., Beppu, T. 1982. Mutants blocked in streptomycin production in Streptomyces griseus the role of A-factor. J. Antibiot. 35: 349-358.
    • (1982) J. Antibiot. , vol.35 , pp. 349-358
    • Hara, O.1    Beppu, T.2
  • 20
    • 0015949374 scopus 로고
    • A linear steady state treatment of enzymatic chains
    • Heinrich, R., Rapoport, T. A. 1974. A linear steady state treatment of enzymatic chains. Eur. J. Biochem. 42: 97-105.
    • (1974) Eur. J. Biochem. , vol.42 , pp. 97-105
    • Heinrich, R.1    Rapoport, T.A.2
  • 23
    • 13344273770 scopus 로고
    • Stimulation of streptomycin formation by Streptomyces griseus grown in a phosphate deficient culture
    • Inoue, S., Nishisawa, Y., Nagai, S. 1982. Stimulation of streptomycin formation by Streptomyces griseus grown in a phosphate deficient culture. J. Ferment. Technol. 60: 417-422.
    • (1982) J. Ferment. Technol. , vol.60 , pp. 417-422
    • Inoue, S.1    Nishisawa, Y.2    Nagai, S.3
  • 24
    • 0015824267 scopus 로고
    • The control of flux
    • D. D. Davies (ed.), Cambridge University Press, Cambridge, UK
    • Kacser, H., Burns, J. A. 1973. The control of flux, pp. 65-104. In: D. D. Davies (ed.), Rate control of biological processes. Cambridge University Press, Cambridge, UK.
    • (1973) Rate Control of Biological Processes , pp. 65-104
    • Kacser, H.1    Burns, J.A.2
  • 25
    • 84909546073 scopus 로고
    • Studies of plasmids in neomycin-producing Streptomyces fradiae
    • Schlessinger (ed.), American Society for Microbiology, Washington, DC
    • Komatsu, K., Leboul, S., Harford, S., Davies, J. 1981. Studies of plasmids in neomycin-producing Streptomyces fradiae, pp. 384-387. In: Schlessinger (ed.), Microbiology. American Society for Microbiology, Washington, DC.
    • (1981) Microbiology , pp. 384-387
    • Komatsu, K.1    Leboul, S.2    Harford, S.3    Davies, J.4
  • 26
    • 0345020338 scopus 로고
    • A study on the regulation of Cephamycin C and expandase biosynthesis by Streptomyces clavuligerus in continuous and batch culture
    • Lebrihi, A., Lefebre, G., Germain, P. A. 1988. A study on the regulation of Cephamycin C and expandase biosynthesis by Streptomyces clavuligerus in continuous and batch culture. Appl. Microbiol. Biotechnol. 28: 39-43.
    • (1988) Appl. Microbiol. Biotechnol. , vol.28 , pp. 39-43
    • Lebrihi, A.1    Lefebre, G.2    Germain, P.A.3
  • 27
    • 0342817498 scopus 로고
    • Control of the production of cephamycin C and thienamycin by Streptomyces cattleya NRRL8057
    • Lilley, G., Clark, A. E., Lawrence, G. C. 1981. Control of the production of cephamycin C and thienamycin by Streptomyces cattleya NRRL8057. J. Chem. Technol. Biotechnol. 31: 127-135.
    • (1981) J. Chem. Technol. Biotechnol. , vol.31 , pp. 127-135
    • Lilley, G.1    Clark, A.E.2    Lawrence, G.C.3
  • 30
    • 0002935655 scopus 로고
    • The bialophos biosynthetic genes of Streptomyces hygroscopicus. Molecular cloning and characterization of the gene cluster
    • Murakami, T., Anzai, H., Imai, S., Satoh, A., Nagaoka, K., Thompson, C. J. 1986. The bialophos biosynthetic genes of Streptomyces hygroscopicus. Molecular cloning and characterization of the gene cluster. Mol. Gen. Genet. 205: 42-50.
    • (1986) Mol. Gen. Genet. , vol.205 , pp. 42-50
    • Murakami, T.1    Anzai, H.2    Imai, S.3    Satoh, A.4    Nagaoka, K.5    Thompson, C.J.6
  • 31
    • 0026782902 scopus 로고
    • A strategy for increasing an in vivo flux by genetic manipulations - The tryptophan system of yeast
    • Niederberger, P., Prasad, R., Miozzari, G., Kacser, H. 1992. A strategy for increasing an in vivo flux by genetic manipulations - the tryptophan system of yeast. Biochem. J. 287: 473-479.
    • (1992) Biochem. J. , vol.287 , pp. 473-479
    • Niederberger, P.1    Prasad, R.2    Miozzari, G.3    Kacser, H.4
  • 32
    • 0023790249 scopus 로고
    • Expression and secretion of interferon-a1 by Streptomyces lividans: Use of staphylokinase signals and amplification of a neo gene
    • Noack, D., Geuther, R., Tonew, M., Breitling, R., Behnke, D. 1988. Expression and secretion of interferon-a1 by Streptomyces lividans: Use of staphylokinase signals and amplification of a neo gene. Gene 68: 53-62.
    • (1988) Gene , vol.68 , pp. 53-62
    • Noack, D.1    Geuther, R.2    Tonew, M.3    Breitling, R.4    Behnke, D.5
  • 33
    • 0020685030 scopus 로고
    • Hydroxystreptomycin production and resistance in Streptomyces glaucescens
    • Ono, H., Crameri, G., Hintermann, G., Hutter, R. 1983. Hydroxystreptomycin production and resistance in Streptomyces glaucescens. J. Gen. Microbiol. 129: 529-537.
    • (1983) J. Gen. Microbiol. , vol.129 , pp. 529-537
    • Ono, H.1    Crameri, G.2    Hintermann, G.3    Hutter, R.4
  • 34
    • 0021412549 scopus 로고
    • The production of oxytetracycline in chemostat culture
    • Rhodes, P. M. 1984. The production of oxytetracycline in chemostat culture. Biotechnol. Bioeng. 26, 382-385.
    • (1984) Biotechnol. Bioeng. , vol.26 , pp. 382-385
    • Rhodes, P.M.1
  • 35
    • 0021197255 scopus 로고
    • Industrial strain improvement. Mutagenesis and random screening procedures
    • Rowlands, R. T. 1984. Industrial strain improvement. Mutagenesis and random screening procedures. Enzyme Microbial Technol. 6: 3-10.
    • (1984) Enzyme Microbial Technol. , vol.6 , pp. 3-10
    • Rowlands, R.T.1
  • 36
    • 77955611817 scopus 로고
    • Overproduction of endo-enzymes in Escherichia coli - Selection of hyperproducing strains in a chemostat
    • V. Krumphanzl, B. Sikyta, and Z. Vanek (eds.), Academic Press, London
    • Sikyta, B., Kyslik, P., Volesky, B., Pavlasova, E., Stejskalova, E. 1982. Overproduction of endo-enzymes in Escherichia coli - Selection of hyperproducing strains in a chemostat. In: V. Krumphanzl, B. Sikyta, and Z. Vanek (eds.), Overproduction of microbial products. Academic Press, London.
    • (1982) Overproduction of Microbial Products
    • Sikyta, B.1    Kyslik, P.2    Volesky, B.3    Pavlasova, E.4    Stejskalova, E.5
  • 37
    • 0024443397 scopus 로고
    • Physiology of amidase production by Methylophilus methylotrophus - Isolation of hyperactive strains using continuous culture
    • Silman, N. J., Carver, M. A., Jones, C. W. 1989. Physiology of amidase production by Methylophilus methylotrophus - isolation of hyperactive strains using continuous culture. J. Gen. Microbiol. 135: 3153-3164.
    • (1989) J. Gen. Microbiol. , vol.135 , pp. 3153-3164
    • Silman, N.J.1    Carver, M.A.2    Jones, C.W.3
  • 38
    • 0026592449 scopus 로고
    • On the evolution of functional secondary metabolites (natural-products)
    • Stone, M. J., Williams, D. H. 1992. On the evolution of functional secondary metabolites (natural-products). Mol. Microbiol. 6: 29-34.
    • (1992) Mol. Microbiol. , vol.6 , pp. 29-34
    • Stone, M.J.1    Williams, D.H.2
  • 39
    • 0025307573 scopus 로고
    • Kinetic studies of streptomycin uptake implicated in self-resistance in a streptomycin producer
    • Sugiyama, M., Mizuno, S., Ohta, Y., Mochizuki, H., Nimi, O. 1990. Kinetic studies of streptomycin uptake implicated in self-resistance in a streptomycin producer. Biotechnol. Lett. 12: 1-6.
    • (1990) Biotechnol. Lett. , vol.12 , pp. 1-6
    • Sugiyama, M.1    Mizuno, S.2    Ohta, Y.3    Mochizuki, H.4    Nimi, O.5
  • 40
    • 0019809460 scopus 로고
    • Mechanism of protection of protein synthesis against streptomycin inhibition in a producing strain
    • Sugiyama, M., Mochizuki, H., Nimi, O., Nomi, R. 1981. Mechanism of protection of protein synthesis against streptomycin inhibition in a producing strain. J. Antibiot. 34: 1183-1188.
    • (1981) J. Antibiot. , vol.34 , pp. 1183-1188
    • Sugiyama, M.1    Mochizuki, H.2    Nimi, O.3    Nomi, R.4
  • 41
    • 0023616194 scopus 로고
    • Relation between growth rate and erythromycin production in S. erythraeus
    • Trilli, A., Crossley, M. V., Kontakou, M. 1987. Relation between growth rate and erythromycin production in S. erythraeus. Biotechnol Lett. 9: 765.
    • (1987) Biotechnol Lett. , vol.9 , pp. 765
    • Trilli, A.1    Crossley, M.V.2    Kontakou, M.3
  • 42
    • 0027332215 scopus 로고
    • Periodic selection in long term continuous-flow cultures of the filamentous fungus Fusarium graminearum
    • Wiebe, M. G., Robson, G. D., Cunliffe, B., Oliver, S. G., Trinci, A. P. J. 1993. Periodic selection in long term continuous-flow cultures of the filamentous fungus Fusarium graminearum. J. Gen. Microbiol. 139: 2811-2817.
    • (1993) J. Gen. Microbiol. , vol.139 , pp. 2811-2817
    • Wiebe, M.G.1    Robson, G.D.2    Cunliffe, B.3    Oliver, S.G.4    Trinci, A.P.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.