Effects of gamma irradiation on solid and lyophilised phospholipids

Radiation Physics and Chemistry

Volumn 56, Issue 5-6, 1999, Pages 611-622

  Stensrud, G ^a   Redford, K ^b   Smistad, G ^a   Karlsen, J ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b SINTEF   (Norway)

Author keywords

Chemical stability; Gamma irradiation; Liposomes; Phospholipids; Physical stability

Indexed keywords

DEGRADATION; DIFFUSION; GAMMA RAYS; LIPIDS; NUCLEAR MAGNETIC RESONANCE; PLASTICITY; RADIATION EFFECTS; SIZE DETERMINATION; SOLIDS; STERILIZATION (CLEANING); TURBIDITY; VISCOSITY MEASUREMENT;

LIPOSOMES; LYOPHILISED PHOSPHOLIPIDS; ZETA POTENTIAL;

IRRADIATION;

DISTEAROYLPHOSPHATIDIC ACID; DISTEAROYLPHOSPHATIDYLCHOLINE; LIPOSOME; PHOSPHOLIPID;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DIFFUSION COEFFICIENT; DRUG DEGRADATION; GAMMA IRRADIATION; HYDRATION; INFRARED SPECTROPHOTOMETRY; LIPID ANALYSIS; MEMBRANE STRUCTURE; NUCLEAR MAGNETIC RESONANCE; PHASE TRANSITION; TECHNIQUE; TURBIDITY; VISCOSITY; X RAY DIFFRACTION;

EID: 0033231517     PISSN: 0969806X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-806X(99)00297-2     Document Type: Article

References (20)

1. Albertini G., Rustichelli F. Effects of gamma irradiation on the liposomal structure. Gregoriadis, G., Liposome Technology; Liposomes Preparation and Related Techniques. Vol.1:1993;CRC Press, Boca Raton, FL.
2. Anderson P.M., Hanson D.C., Hasz D.E., Halet M.R., Blazar B.R., Ochoa A. Cytokines in liposomes: Preliminary studies with IL-1, IL-6, GM-CSF and interferon-γ Cytokine. 6:1994;92.
3. Biltonen R.L., Lichtenberg D. The use of differential scanning calorimetry as a tool to characterize liposome preparations. Chem. Phys. Lipids. 64:1993;129.
4. Coune A., Sculier J.P., Frühling J., Stryckmans P., Brassinne C., Ghanem G., Laduron C., Atassi G., Ruysschaert J.M., Hildebrand J. Iv administration of a water-insoluble antimitotic compound entrapped in liposomes. Preliminary report on infusion of large volumes of liposomes to man. Cancer Treat. Rep. 70:1983;1031.
5. Einstein A. Eine neue Bestimmung der Molekül-dimensionen. Ann. Phys. 19:1906;289.
6. Einstein A. Berichtungen zu meiner Arbeit: "Eine neue Bestimmung der Molekül-dimensionen" Ann. Phys. 34:1911;591.
7. Pharmacopoea Nordica, 1963 Vol.1.
8. Reid B.D. Gamma processing technology: an alternative technology for terminal sterilization of parenterals. PDA J. Pharm. Sci. Technol. 49:1995;83.
9. Samuni A.M., Barenholz Y., Crommelin D.J.A., Zuidam N.J. γ-Irradiation damage to liposomes differing in composition and their protection by nitroxides. Free Radical Biology & Medicine. 23:1997;972.
10. Sculier J.P., Coune A., Brassinne C., Laduron C., Atassi G., Ruysschaert J.M., Frühling J. Intravenous infusion of high doses of liposomes containing NSC 251635, a water-insoluble cytostatic agent. A pilot study with pharmacokinetic data. J. Clin. Oncol. 4:1986;789.
11. Stark G. The effect of ionizing radiation on lipid membranes. Biochim. Biophys. Acta. 1071:1991;103.
12. Stensrud G., Smistad G., Karlsen J. Effects of gamma irradiation on the stability of liposomes/phospholipids. 1. Chemical stability. Drug Stability. 1:1996;152.
13. Stensrud, G., Smistad, G., Ågren, T.L., Sande, S.A., Karlsen, J. 1997 Effects of gamma irradiation on the physical stability of liposomal phospholipids. J. Lipos. Res. 7, 503. Erratum; J. Lipos. Res. 8, 297 (1998).
14. Stensrud G., Passi S., Ågren T.L., Sandset P.M., Smistad G., Mönkkönen J., Karlsen J. Toxicity of gamma irradiated liposomes; 1. In vitro interactions with blood components. Int. J. Pharm. 178:1999;33.
15. Stensrud G., Mönkkönen J., Karlsen J. Toxicity of gamma irradiated liposomes; 2. in vitro effects on cells in culture. Int. J. Pharm. 178:1999;47.
16. Tinsley P.W., Maerker G. Effect of low-dose γ-radiation on individual phospholipids in aqueous suspension. JAOCS. 70:1993;187.
17. Woods R.J., Pikaev A.K. Radiation sterilization of medical products. Woods R.J., Pikaev A.K. Applied Radiation Chemistry. 1994;Wiley, New York.
18. Zuidam N.J., Lee S.S.L., Crommelin D.J.A. Gamma-irradiation of non-frozen, frozen and freeze-dried liposomes. Pharm. Res. 12:1995;1761.
19. Zuidam N.J., Talsma H., Crommelin D.J.A. Sterilization of liposomes. Barenholz Y., Lasic D.D. Nonmedical Application of Liposomes. 1996;CRC Press, Boca Raton, FL.
20. Zuidam N.J., Versluis C., Vernooy E.A.A.M., Crommelin D.J.A. Gamma-irradiation of liposomes composed of saturated phospholipids. Effect of bilayer composition, size, concentration and absorbed dose on chemical degradation and physical destabilization of liposomes. Biochim. Biophys. Acta. 1280:1996;135.