CFP, the putative cercosporin transporter of Cercospora kikuchii, is required for wild type cercosporin production, resistance, and virulence on soybean

Molecular Plant-Microbe Interactions

Volumn 12, Issue 10, 1999, Pages 901-910

  Callahan, Terrence M ^a,b   Rose, Mark S ^a,d   Meade, Maura J ^a,c   Ehrenshaft, Marilyn ^a   Upchurch, Robert G ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b LAKE ERIE COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

^c ALLEGHENY COLLEGE   (United States)

^d NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Drug; Proton antiporter

Indexed keywords

AMINO ACID SEQUENCE; CERCOSPORIN; COMPLEMENTARY DNA; FUNGAL GENE; MESSENGER RNA; MUTAGENESIS; OPEN READING FRAME; SEQUENCE ANALYSIS;

ANIMALIA; CERCOSPORA KIKUCHII; FUNGI; GLYCINE MAX;

EID: 0033215141     PISSN: 08940282     EISSN: None     Source Type: Journal    
DOI: 10.1094/MPMI.1999.12.10.901     Document Type: Article

References (42)

1. Alexander, N. J., Hohn, T. M., and McCormick, S. P. 1997. Molecular characterization of TRI12 which encodes an apparent transport protein involved in trichothecene production by Fusarium sporotrichioides. Cereal Res. Commun. 25:347-348.
2. Altschul, S. F., Gish, W., Miller, W., Myers, E. W., and Lipman, D. J. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
3. Assante, G., Locci, R., Camarda, L., Merlini, L., and Nasini, G. 1977. Screening of the genus Cercospora for secondary metabolites. Phytochemistry 16:243-247.
4. Daub, M. E. 1982a. Cercosporin, a photosensitizing toxin from Cercospora species. Phytopathology 72:370-374.
5. Daub, M. E. 1982b. Peroxidation of tobacco membrane lipids by the photosensitizing toxin, cercosporin. Plant Physiol. 69:1361-1364.
6. Daub, M. E. 1987. The fungal photosensitizer cercosporin and its role in plant disease. ACS Symp. Ser. 339:271-280.
7. Daub, M. E., Ehrenshaft, M., Jenns, A. E., and Chung, K. R. 1998. Active oxygen in fungal pathogenesis of plants: The role of cercosporin in Cercospora diseases. Pages 31-56 in: Advances in Phytochemistry. J. Romero, K. Downum, and R. Verpoorte, eds. Plenum Press, New York.
8. Daub, M. E., and Hangarter, R. P. 1983. Light-induced production of singlet oxygen and Superoxide by the fungal toxin, cercosporin. Plant Physiol. 73:855-857.
9. Daub, M. E., Leisman, G. B., Clark, R. A., and Bowden, E. F. 1992. Reductive detoxification as a mechanism of fungal resistance to singlet-oxygen-generating photosensitizers. Proc. Natl. Acad. Sci. USA 89:9588-9592.
10. Edelmann, S. E., and Staben, C. 1994. A statistical analysis of sequence features within genes from Neurospora crassa. Exp. Mycol. 18:70-81.
11. Ehrenhofer-Murray, A. E., Wuergler, F. E., and Sengstag, C. 1994. The Saccharomyces cerevisiae SGE1 gene product: A novel drug-resistance protein within the major facilitator superfamily. Mol. Gen. Genet. 224:287-294.
12. Ehrenshaft, M., Chung, K. R., Jenns, A. E., and Daub M. E. 1999. Functional characterization of SOR1, a gene required for resistance to photosensitizing toxins in the fungus Cercospora nicotianae. Curr. Genet. 34:478-485.
13. Ehrenshaft, M., Jenns, A. E., Chung, K. R., and Daub, M. E. 1998. SOR1, a gene requires for photosensitizer and singlet oxygen resistance in Cercospora fungi, is highly conserved in divergent organisms. Mol. Cell 1:603-609.
14. Ehrenshaft, M., and Upchurch, R. G. 1991. Isolation of light-enhanced cDNAs of Cercospora kikuchii. Appl. Environ. Microbiol. 57:2671-2676.
15. Garber, R. C., and Yoder, O. C. 1983. Isolation of DNA from filamentous fungi and separation into nuclear, mitochondrial, ribosomal, and plasmid components. Anal. Biochem. 135:416-422.
16. Gish, W., and States, D. J. 1993. Identification of protein coding regions by database similarity search. Nat. Genet. 3:266-272.
17. Hightower R. C., Callahan, T. M., and Upchurch, R. G. 1995. Electrophoretic karyotype of Cercospora kikuchii. Curr. Genet. 27:290-292.
18. Hoffman, K., and Stoffel, W. 1993. Tmbase-A database of membrane spanning protein segments. Biol. Chem. Hoppe-Seyler. 347:166.
19. Jenns, A. E., and Daub, M. E. 1995. Characterization of mutants of Cercospora nicotianae sensitive to the toxin cercosporin. Phytopathology 85:906-912.
20. Jenns, A. E., Daub, M. E., and Upchurch, R. G. 1989. Regulation of cercosporin accumulation in culture by medium and temperature manipulation. Phytopathology 79:213-219.
21. Jenns, A. E., Scott. D. L., Bowden, E. F., and Daub, M. E. 1995. Isolation of mutants of the fungus Cercospora nicotianae altered in their response to singlet-oxygen-generating photosensitizers. Photochem. Photobiol. 61:488-493.
22. Kyte, J., and Doolittle, R. F. 1982. A simple method for displaying the hydrophobic character of a protein. J. Mol. Biol. 157:105-132.
23. Leisman, G. B., and Daub, M. E. 1992. Singlet oxygen yields, optical properties, and phototoxicity of reduced derivatives of the photosensitizer cercosporin. Photochem. Photobiol. 55:373-379.
24. Lousberg, R. L. J. C., Weiss, U., Salemink, C. A., Merlini, A., and Nasini, G. 1971. The structure of cercosporin, a naturally occurring quinone. J. Chem. Soc. Chem. Commun. 1971:1463-1464.
25. Lynch, F. J., and Geoghegan, M. J. 1979. Regulation of growth and cercosporin photoinduction in Cercospora beticola. Trans. Br. Mycol. Soc. 73:311-327.
26. Macri, F. A., and Vianello, M. 1979. Photodynamic activity of cercosporin on plant tissues. Plant Cell Environ. 2:267-271.
27. Marger, M. D., and Saier, M. H. 1993. A major superfamily of transmembrane facilitators that catalyze uniport, synport and antiport. Trends Biochem. Sci. 18:13-20.
28. Okubo, A., Yamazaki, S., and Fuwa, K. 1975. Biosynthesis of cercosporin. Agric. Biol. Chem. 39:1173-1175.
29. Paulsen, I. T., Brown, M. H., Littlejohn, T. G., Mitchell, B. A., and Skurray, R. A. 1996a. Molecular characterization of the multidrug resistance proteins QacA and QacB: Membrane topology and identification of residues involved in specificity for divalent cations. Proc. Natl. Acad. Sci. USA 93:3630-3635.
30. Paulsen, I. T., Brown, M. H., and Skurry, R. H. 1996b. Proton-dependent multidrug efflux systems. Microbiol. Rev. 60:575-608.
31. Pineiro, M., Garcia-Olmedo, F., and Diaz, I. 1994. Redox modulation of the expression of bacterial genes encoding cysteine-rich proteins in plant protoplasts. Proc. Natl. Acad. Sci. USA 91:3867-3871.
32. Pitkin, J. W., Panaccione, D. G., and Walton, J. D. 1996. A putative cyclic peptide efflux pump encoded by the TOXA gene of the plant-pathogenic fungus Cochliobolus carbonum. Microbiology 142:1557-565.
33. Quigley, N. B., Mo, Y.-Y., and Gross, D. C. 1993. SyrD is required for syringomycin production by Pseudomonas syringae pathovar syringae and is related to a family of ATP-binding secretion proteins. Mol. Microbiol. 9:787-801.
34. Roberts, I. N., Oliver, R. P., Punt, P. J., and van den Hondel, C. A. M. J. J. 1989. Expression of the Escherichia coli β-glucuronidase gene in industrial and phytopathogenic filamentous fungi. Curr. Genet. 15:177-180.
35. Rollins, J. A., Ehrenshaft, M., and Upchurch, R. G. 1993. Effects of light and altered-cercosporin phenotypes on gene expression in Cercospora kikuchii. Can. J. Microbiol. 39:118-124.
36. Sambrook, J., Fritsch, E. F., and Maniatis, T. A. 1989. Molecular Cloning: A Laboratory Manual. 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
37. Sollod-Cooperman, C., Jenns, A. E., and Daub, M. E. 1992. Cell surface redox potential as a mechanism of defense against photosensitizers in fungi. Appl. Environ. Microbiol. 58:444-449.
38. Straubinger, B., Straubinger, E., Wirsel, S., Turgeon, G., and Yoder, O. 1992. Versatile fungal transformation vectors carrying the selectable bar gene of Streptomyces hygroscopicus. Fungal Genet. Newsl. 39: 82-83.
39. Turgeon, B. G., Garber, R. C., and Yoder, O. C. 1987. Development of a fungal transformation system based on selection of sequences with promoter activity. Mol. Cell. Biol. 7:3297-3305.
40. Upchurch, R. G., Meade, M. J., Hightower, R. C., Thomas, R. S., and Callahan, T. M. 1994. Transformation of the fungal soybean pathogen Cercospora kikuchii with the selectable marker bar. Appl. Environ. Microbiol. 60:4592-4595.
41. Upchurch, R. G., Walker, D. C., Rollins, J. A., Ehrenshaft, M., and Daub, M. E. 1991. Mutants of Cercospora kikuchii altered in cercosporin synthesis and pathogenicity. Appl. Environ. Microbiol. 57: 2940-2945.
42. Yamazaki, S., and Ogawa, T. 1972. The chemistry and stereochemistry of cercosporin. Agric. Biol. Chem. 36:1707-1718.