-
1
-
-
0025111068
-
Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53
-
1. Michalovitz, D., Halevy, O. & Oren, M. (1990), Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell 62, 671-680.
-
(1990)
Cell
, vol.62
, pp. 671-680
-
-
Michalovitz, D.1
Halevy, O.2
Oren, M.3
-
2
-
-
0025784539
-
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
-
2. Yonish-Rouach, E., Resnitzky, D., Lotem, J., Sachs, L., Kimchi, A. & Oren, M. (1991). Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 352, 345-347.
-
(1991)
Nature
, vol.352
, pp. 345-347
-
-
Yonish-Rouach, E.1
Resnitzky, D.2
Lotem, J.3
Sachs, L.4
Kimchi, A.5
Oren, M.6
-
3
-
-
0028070989
-
p53-dependent apoptosis in the absence of transcriptional activation of p53 target genes
-
3. Caelles, C., Helmberg, A. & Karin, M. (1994). p53-dependent apoptosis in the absence of transcriptional activation of p53 target genes. Nature 370, 220-223.
-
(1994)
Nature
, vol.370
, pp. 220-223
-
-
Caelles, C.1
Helmberg, A.2
Karin, M.3
-
4
-
-
0029815092
-
Regulation of mutant p53 temperature-sensitive DNA binding
-
4. Friedlander, P., Legros, Y., Soussi, T. & Prives, C. (1996). Regulation of mutant p53 temperature-sensitive DNA binding. J. Biol. Chem. 271, 25468-25478.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 25468-25478
-
-
Friedlander, P.1
Legros, Y.2
Soussi, T.3
Prives, C.4
-
5
-
-
0014933756
-
Rous sarcoma virus: A function required for the maintenance of the transformed state
-
5. Martin, G.S. (1970). Rous sarcoma virus: a function required for the maintenance of the transformed state. Nature 227, 1021-1023.
-
(1970)
Nature
, vol.227
, pp. 1021-1023
-
-
Martin, G.S.1
-
6
-
-
0018851827
-
Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus
-
6. Sefton, B.M., Hunter, T., Beemon, K. & Eckhart, W. (1980). Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus. Cell 20, 807-816.
-
(1980)
Cell
, vol.20
, pp. 807-816
-
-
Sefton, B.M.1
Hunter, T.2
Beemon, K.3
Eckhart, W.4
-
7
-
-
0028859279
-
Protein modules and signalling networks
-
7. Pawson, T. (1995). Protein modules and signalling networks. Nature 373, 573-580.
-
(1995)
Nature
, vol.373
, pp. 573-580
-
-
Pawson, T.1
-
8
-
-
0028895654
-
Modular binding domains in signal transduction proteins
-
8. Cohen, G.B., Ren, R. & Baltimore, D. (1995). Modular binding domains in signal transduction proteins. Cell 80, 237-248.
-
(1995)
Cell
, vol.80
, pp. 237-248
-
-
Cohen, G.B.1
Ren, R.2
Baltimore, D.3
-
9
-
-
0029830139
-
The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1
-
9. Galisteo, M.L., Chernoff, J., Su, Y.C., Skolnik, E.Y. & Schlessinger, J. (1996). The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1. J. Biol. Chem. 271, 20997-21000.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 20997-21000
-
-
Galisteo, M.L.1
Chernoff, J.2
Su, Y.C.3
Skolnik, E.Y.4
Schlessinger, J.5
-
10
-
-
0029911521
-
Interaction of the Nck adapter protein with p21 -activated kinase (PAK1)
-
10. Bokoch, G.M., Wang, Y., Bohl, B.P., Sells, M.A, Quilliam, L.A. & Knaus, U.G. (1996). Interaction of the Nck adapter protein with p21 -activated kinase (PAK1). J. Biol. Chem. 271, 25746-25749.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 25746-25749
-
-
Bokoch, G.M.1
Wang, Y.2
Bohl, B.P.3
Sells, M.A.4
Quilliam, L.A.5
Knaus, U.G.6
-
11
-
-
0031080595
-
Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck
-
11. Lu, W., Katz, S., Gupta, R. & Mayer, B.J. (1997). Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck. Curr. Biol. 7, 85-94.
-
(1997)
Curr. Biol.
, vol.7
, pp. 85-94
-
-
Lu, W.1
Katz, S.2
Gupta, R.3
Mayer, B.J.4
-
12
-
-
0025273452
-
Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the Src homology units SH2 and SH3
-
12. Lehmann, J.M., Riethmuller, G. & Johnson, J.P. (1990). Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the Src homology units SH2 and SH3. Nucleic Acids Res. 18, 1048.
-
(1990)
Nucleic Acids Res.
, vol.18
, pp. 1048
-
-
Lehmann, J.M.1
Riethmuller, G.2
Johnson, J.P.3
-
13
-
-
0028078824
-
A brain serine/threonine protein kinase activated by Cdc42 and Rac1
-
13. Manser, E., Leung, T., Salihuddin, H., Zhao, Z.S. & Lim, L. (1994). A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367, 40-46.
-
(1994)
Nature
, vol.367
, pp. 40-46
-
-
Manser, E.1
Leung, T.2
Salihuddin, H.3
Zhao, Z.S.4
Lim, L.5
-
14
-
-
0028998794
-
Regulation of human leukocyte p21-activated kinases through G protein-coupled receptors
-
14. Knaus, U.G., Morris, S., Dong, H.J., Chernoff, J. & Bokoch, G.M. (1995). Regulation of human leukocyte p21-activated kinases through G protein-coupled receptors. Science 269, 221-223.
-
(1995)
Science
, vol.269
, pp. 221-223
-
-
Knaus, U.G.1
Morris, S.2
Dong, H.J.3
Chernoff, J.4
Bokoch, G.M.5
-
15
-
-
0029056399
-
A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20
-
15. Martin, G.A., Bollag, G., McCormick, F. & Abo, A. (1995). A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO J. 14, 4385.
-
(1995)
EMBO J.
, vol.14
, pp. 4385
-
-
Martin, G.A.1
Bollag, G.2
McCormick, F.3
Abo, A.4
-
16
-
-
0031036626
-
Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes
-
16. Manser, E., et al., & Lim, L. (1997). Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes. Mol. Cell. Biol. 17, 1129-1143.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 1129-1143
-
-
Manser, E.1
Lim, L.2
-
17
-
-
0031105660
-
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells
-
17. Sells, M.A., Knaus, U.G., Bagrodia, S., Ambrose, D.M., Bokoch, G.M. & Chernoff, J. (1997). Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr. Biol. 7, 202-210.
-
(1997)
Curr. Biol.
, vol.7
, pp. 202-210
-
-
Sells, M.A.1
Knaus, U.G.2
Bagrodia, S.3
Ambrose, D.M.4
Bokoch, G.M.5
Chernoff, J.6
-
18
-
-
0032561355
-
Differential effects of PAK1 -activating mutations reveal activity- dependent and -independent effects on cytoskeletal regulation
-
18. Frost, J.A., Khokhlatchev, A., Stippec, S., White, M.A. & Cobb, M.H. (1998). Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation. J. Biol. Chem. 273, 28191-28198.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 28191-28198
-
-
Frost, J.A.1
Khokhlatchev, A.2
Stippec, S.3
White, M.A.4
Cobb, M.H.5
-
19
-
-
0031948850
-
A conserved negative regulatory region in alphaPAK: Inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1
-
19. Zhao, Z.S., Manser, E., Chen, X.Q., Chong, C., Leung, T. & Lim, L. (1998). A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1. Mol. Cell Biol. 18, 2153-2163.
-
(1998)
Mol. Cell Biol.
, vol.18
, pp. 2153-2163
-
-
Zhao, Z.S.1
Manser, E.2
Chen, X.Q.3
Chong, C.4
Leung, T.5
Lim, L.6
-
20
-
-
0027279176
-
How receptor tyrosine kinases activate Ras
-
20. Schlessinger, J. (1993). How receptor tyrosine kinases activate Ras. Trends Biochem. Sci. 18, 273-275.
-
(1993)
Trends Biochem. Sci.
, vol.18
, pp. 273-275
-
-
Schlessinger, J.1
-
21
-
-
0023864050
-
A novel viral oncogene with structural similarity to phospholipase C
-
21. Mayer, B.J., Hamaguchi, M. & Hanafusa, H. (1988). A novel viral oncogene with structural similarity to phospholipase C. Nature 332, 272-275.
-
(1988)
Nature
, vol.332
, pp. 272-275
-
-
Mayer, B.J.1
Hamaguchi, M.2
Hanafusa, H.3
-
22
-
-
0026686182
-
Two species of human CRK cDNA encode proteins with distinct biological activities
-
22. Matsuda, M., Tanaka, S., Nagata, S., Kojima, A., Kurata, T. & Shibuya, M. (1992). Two species of human CRK cDNA encode proteins with distinct biological activities. Mol. Cell. Biol. 12, 3482-3489.
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 3482-3489
-
-
Matsuda, M.1
Tanaka, S.2
Nagata, S.3
Kojima, A.4
Kurata, T.5
Shibuya, M.6
-
23
-
-
0028789982
-
Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins
-
23. Tanaka, M., Gupta, R. & Mayer, B.J. (1995). Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins. Mol. Cell. Biol. 15, 6829-6837.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 6829-6837
-
-
Tanaka, M.1
Gupta, R.2
Mayer, B.J.3
-
24
-
-
0028485085
-
High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides
-
24. Musacchio, A., Saraste, M. & Wilmanns, M. (1994). High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides. Nat. Struct. Biol. 1, 546-551.
-
(1994)
Nat. Struct. Biol.
, vol.1
, pp. 546-551
-
-
Musacchio, A.1
Saraste, M.2
Wilmanns, M.3
-
25
-
-
0025352651
-
Mutagenic analysis of the v-crk oncogene: Requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation
-
25. Mayer, B.J. & Hanafusa, H. (1990). Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation. J. Virol. 64, 3581-3589.
-
(1990)
J. Virol.
, vol.64
, pp. 3581-3589
-
-
Mayer, B.J.1
Hanafusa, H.2
-
26
-
-
0027990414
-
A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner
-
26. Sakai, R., et al., & Hirai, H. (1994). A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J. 13, 3748-3756.
-
(1994)
EMBO J.
, vol.13
, pp. 3748-3756
-
-
Sakai, R.1
Hirai, H.2
-
27
-
-
0029257493
-
Evidence that SH2 domains promote processive phosphorylation by protein- tyrosine kinases
-
27. Mayer, B. J., Hirai, H. & Sakai, R. (1995). Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases. Curr. Biol. 5, 296-305.
-
(1995)
Curr. Biol.
, vol.5
, pp. 296-305
-
-
Mayer, B.J.1
Hirai, H.2
Sakai, R.3
-
28
-
-
0028181873
-
Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites
-
28. Ren, R., Ye, Z.S. & Baltimore, D. (1994). Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites. Genes Dev. 8, 783-795.
-
(1994)
Genes Dev.
, vol.8
, pp. 783-795
-
-
Ren, R.1
Ye, Z.S.2
Baltimore, D.3
-
29
-
-
0028243505
-
c-Abl kinase regulates the protein binding activity of c-Crk
-
29. Feller, S.M., Knudsen, B. & Hanafusa, H. (1994). c-Abl kinase regulates the protein binding activity of c-Crk. EMBO J. 13, 2341-2351.
-
(1994)
EMBO J.
, vol.13
, pp. 2341-2351
-
-
Feller, S.M.1
Knudsen, B.2
Hanafusa, H.3
-
30
-
-
0023668221
-
Temperature-sensitive mutations of bacteriophage T4 lysozyme occur at sites with low mobility and low solvent accessibility in the folded protein
-
30. Alber, T., Sun, D.P., Nye, J.A., Muchmore, D.C. & Matthews, B.W. (1987). Temperature-sensitive mutations of bacteriophage T4 lysozyme occur at sites with low mobility and low solvent accessibility in the folded protein. Biochemistry 26, 3754-3758.
-
(1987)
Biochemistry
, vol.26
, pp. 3754-3758
-
-
Alber, T.1
Sun, D.P.2
Nye, J.A.3
Muchmore, D.C.4
Matthews, B.W.5
-
31
-
-
0032478605
-
A GTPase-independent mechanism of p21 -activated kinase activation. Regulation by sphingosine and other biologically active lipids
-
31. Bokoch, G.M., et al., & Knaus, U.G. (1998). A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids. J. Biol. Chem. 273, 8137-8144.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 8137-8144
-
-
Bokoch, G.M.1
Knaus, U.G.2
-
32
-
-
0033590651
-
Mechanism of activation of Pak1 kinase by membrane localization
-
32. Lu, W. & Mayer, B.J. (1999). Mechanism of activation of Pak1 kinase by membrane localization. Oncogene 18, 797-806.
-
(1999)
Oncogene
, vol.18
, pp. 797-806
-
-
Lu, W.1
Mayer, B.J.2
-
33
-
-
0026720075
-
Tight control of gene expression in mammalian cells by tetracycline- responsive promoters
-
33. Gossen, M. & Bujard, H. (1992). Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl Acad. Sci. USA 89, 5547-5551.
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 5547-5551
-
-
Gossen, M.1
Bujard, H.2
-
34
-
-
0028233970
-
The nuclear tyrosine kinase c-Abl negatively regulates cell growth
-
34. Sawyers, C.L., McLaughlin, J., Goga, A., Havlik, M. & Witte, O. (1994). The nuclear tyrosine kinase c-Abl negatively regulates cell growth. Cell 77, 121-131.
-
(1994)
Cell
, vol.77
, pp. 121-131
-
-
Sawyers, C.L.1
McLaughlin, J.2
Goga, A.3
Havlik, M.4
Witte, O.5
-
35
-
-
0024343691
-
N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl
-
35. Jackson, P. & Baltimore, D. (1989). N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl. EMBO J. 8, 449-456.
-
(1989)
EMBO J.
, vol.8
, pp. 449-456
-
-
Jackson, P.1
Baltimore, D.2
-
36
-
-
0024461553
-
Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential
-
36. Franz, W.M., Berger, P. & Wang, J.Y. (1989). Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential. EMBO J. 8, 137-147.
-
(1989)
EMBO J.
, vol.8
, pp. 137-147
-
-
Franz, W.M.1
Berger, P.2
Wang, J.Y.3
-
37
-
-
0031444104
-
Folding dynamics of the src SH3 domain
-
37. Grantcharova, V.P. & Baker, D. (1997). Folding dynamics of the src SH3 domain. Biochemistry 36, 15685-15692.
-
(1997)
Biochemistry
, vol.36
, pp. 15685-15692
-
-
Grantcharova, V.P.1
Baker, D.2
-
38
-
-
0032570543
-
Folding kinetics of the SH3 domain of PI3 kinase by real-time NMR combined with optical spectroscopy
-
38. Guijarro, J.I., Morton, C.J., Plaxco, K.W., Campbell, I.D. & Dobson, C.M. (1998). Folding kinetics of the SH3 domain of PI3 kinase by real-time NMR combined with optical spectroscopy. J. Mol. Biol. 276, 657-667.
-
(1998)
J. Mol. Biol.
, vol.276
, pp. 657-667
-
-
Guijarro, J.I.1
Morton, C.J.2
Plaxco, K.W.3
Campbell, I.D.4
Dobson, C.M.5
-
39
-
-
0032562182
-
The folding kinetics and thermodynamics of the Fyn-SH3 domain
-
39. Plaxco, K.W., Guijarro, J.I., Morton, C.J., Pitkeathly, M., Campbell, I.D. & Dobson, C.M. (1998). The folding kinetics and thermodynamics of the Fyn-SH3 domain. Biochemistry 37, 2529-2537.
-
(1998)
Biochemistry
, vol.37
, pp. 2529-2537
-
-
Plaxco, K.W.1
Guijarro, J.I.2
Morton, C.J.3
Pitkeathly, M.4
Campbell, I.D.5
Dobson, C.M.6
-
40
-
-
0026501752
-
A rapid method for localized mutagenesis of yeast genes
-
40. Muhlrad, D., Hunter, R. & Parker, R. (1992). A rapid method for localized mutagenesis of yeast genes. Yeast 8, 79-82.
-
(1992)
Yeast
, vol.8
, pp. 79-82
-
-
Muhlrad, D.1
Hunter, R.2
Parker, R.3
-
41
-
-
0024520745
-
Site-directed mutagenesis by overlap extension using the polymerase chain reaction
-
41. Ho, S.N., Hunt, H.D., Horton, R.M., Pullen, J.K. & Pease, L.R. (1989). Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77, 51-59.
-
(1989)
Gene
, vol.77
, pp. 51-59
-
-
Ho, S.N.1
Hunt, H.D.2
Horton, R.M.3
Pullen, J.K.4
Pease, L.R.5
-
42
-
-
0025352187
-
Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
-
42. Morgenstern, J.P. & Land, H. (1990). Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 18, 3587-3596.
-
(1990)
Nucleic Acids Res.
, vol.18
, pp. 3587-3596
-
-
Morgenstern, J.P.1
Land, H.2
-
43
-
-
0023932443
-
Monoclonal antibodies to phosphotyrosine
-
43. Glenney, J.R., Jr., Zokas, L. & Kamps, M.P. (1988). Monoclonal antibodies to phosphotyrosine. J. Immunol. Methods 109, 277-285.
-
(1988)
J. Immunol. Methods
, vol.109
, pp. 277-285
-
-
Glenney J.R., Jr.1
Zokas, L.2
Kamps, M.P.3
|