Hyperactivity caused by a nitric oxide synthase inhibitor is countered by ultra-wideband pulses

Bioelectromagnetics

Volumn 20, Issue 7, 1999, Pages 431-439

  Seaman, Ronald L ^a,b   Belt, Michelle L ^a   Doyle, Joanne M ^a   Mathur, Satnam P ^a  

^a USAF   (United States)

^b Armstrong Laboratory   (United States)

Author keywords

CF 1 mice; Hyperactivity; L NAME; Locomotor activity; Nociception; UWB electromagnetic pulses

Indexed keywords

AMINO ACIDS; ELECTRIC FIELDS; ELECTROMAGNETIC PULSE; MAMMALS; NITRIC OXIDE; ULTRA-WIDEBAND (UWB);

CF-1 MOUSE; HYPERACTIVITY; L-NAME; LOCOMOTOR ACTIVITY; NITRIC OXIDE SYNTHASE INHIBITORS; NITRIC OXIDE SYNTHASES; NOCICEPTION; THERMAL; ULTRA-WIDEBAND ELECTROMAGNETIC PULSE; ULTRA-WIDEBAND PULSE;

ELECTROMAGNETIC FIELDS;

ANIMALIA;

ENZYME INHIBITOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; SODIUM CHLORIDE;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; ELECTROMAGNETIC FIELD; HYPERKINESIA; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MALE; MOUSE; MOUSE STRAIN; NOCICEPTIVE RECEPTOR; PAIN; PAIN THRESHOLD; RADIATION EXPOSURE; REACTION TIME; TIME;

ANALYSIS OF VARIANCE; ANIMALS; ELECTROMAGNETIC FIELDS; ENZYME INHIBITORS; HYPERKINESIS; INJECTIONS, INTRAPERITONEAL; LOCOMOTION; MALE; MICE; MICE, INBRED STRAINS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NOCICEPTORS; PAIN; PAIN THRESHOLD; REACTION TIME; SODIUM CHLORIDE; TIME FACTORS;

EID: 0033210885     PISSN: 01978462     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-186X(199910)20:7<431::AID-BEM4>3.0.CO;2-Y     Document Type: Article

References (57)

1. Agee FJ, Baum CE, Prather WD, Lehr JM, O'Loughlin JP, Burger JW, Schoenberg JSH, Scholfield DW, Torres RJ, Hull JP, Gaudet JA. 1998. Ultra-wideband transmitter research. IEEE Trans Plasma Sci 26:860-873.
2. Babbedge RC, Hart SL, Moore PK. 1993. Anti-nociceptive activity of nitric oxide synthase inhibitors in the mouse: dissociation between the effect of L-NAME and L-NMMA. J Pharm Pharmacol 45 77-79.
3. Bao JZ. 1997. Picosecond domain electromagnetic pulse measurements in an exposure facility: an error compensation routine using deconvolution techniques. Rev Sci Instrum 68:2221-2227.
4. Bawin SM, Satmary WM, Jones RA, Adey WR, Zimmerman G. 1996. Extremely-low-frequency magnetic fields disrupt rhythmic slow activity in rat hippocampal slices. Bioelectromagnetics 17:388-395.
5. Betancur C, Dell'Omo G, Alleva E. 1994. Magnetic field effects on stress-induced analgesia in mice: modulation by light. Neurosci Lett 182:147-150.
6. Bredt DS, Snyder SH. 1994. Nitric oxide: a physiologic messenger molecule. Annu Rev Biochem 63:175-195.
7. Brignola G, Calignano A, Di Rosa M. 1994. Modulation of morphine antinociception in the mouse by endogenous nitric oxide. Br J Pharmacol 113:1372-1376.
8. Calignano A, Persico P, Mancuso F, Sorrentino L. 1993. Endogenous nitric oxide modulates morphine-induced changes in locomotion and food intake in mice. Eur J Pharmacol 231:415-419.
9. Connop BP, Rolfe NG, Boegman RJ, Jhamandas K, Beninger RJ. 1994. Potentiation of NMDA-mediated toxicity on nigrostriatal neurons by a low dose of 7-nitro indazole. Neuropharmacology 33:1439-1445.
10. Cowan A. 1993. Effects of opioids on the spontaneous behavior of animals. In: Herz A, editor. Handbook of experimental pharmacology, 104/II: opioids II. Berlin: Springer-Verlag. pp 393-428.
11. G-monomethyl arginine (L-NMMA) and L-arginine on the antinociceptive effects of morphine in mice. Methods Find Exp Clin Pharmacol 17:577-582.
12. Del Seppia C, Ghione S, Luschi P, Papi F. 1995. Exposure to oscillating magnetic fields influences sensitivity to electrical stimuli. I. Experiments on pigeons. Bioelectromagnetics 16:290-294.
13. Durney CH, Massoudi H, Iskander MF. 1986. Radiofrequency radiation dosimetry handbook. Technical Report USAF-SAM-TR-85-73. Brooks Air Force Base, Texas: USAF School of Aerospace Medicine.
14. Dzoljic E, De Vries R, Dzoljic MR. 1997. New and potent inhibitors of nitric oxide synthase reduce motor activity in mice. Behav Brain Res 87:209-212.
15. Fleming JL, Persinger MA, Koren SA. 1994. Magnetic pulses elevate nociceptive thresholds: comparisons with opiate receptor compounds in normal and seizure-induced brain-damaged rats. Electromagnetobiol 13:67-75.
16. Ghione S. 1996. Hypertension-associated hypalgesia: evidence in experimental animals and humans, pathophysiological mechanisms, and potential clinical consequences. Hypertension 28:494-504.
17. Guasti L, Grimoldi P, Diolisi A, Petrozzino MR, Gaudio G, Grandi AM, Rossi MG, Venco A. 1998. Treatment with enalapril modifies the pain perception pattern in hypertensive patients. Hypertension 31:1146-1150.
18. G-nitroarginine methyl ester (L-NAME) on morphine-induced analgesia. Chronobiol Int 15:283-289.
19. Handy RL, Moore PK. 1998. Effects of selective inhibitors of neuronal nitric oxide synthase carrageenan-induced mechanical and thermal hyperalgesia. Neuropharmacology 37:37-43.
20. Handy RL, Harb HL, Wallace P, Gaffen Z, Whitehead KJ, Moore PK. 1996. Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects. Br J Pharmacol 119: 423-431.
21. Hu CT, Chang KC, Wu CY, Chen HI. 1997. Acute effects of nitric oxide blockade with L-NAME on arterial haemodynamics in the rat. Br J Pharmacol 122:1237-1243.
22. Jauchem JR, Seaman RL, Lehnert HM, Mathur SP, Ryan KL, Frei MR, Hurt WD. 1998. Ultra-wideband electromagnetic pulses: lack of effects on heart rate and blood pressure during two-minute exposures of rats. Bioelectromagnetics 19:330-333.
23. Jauchem JR, Frei MR, Ryan KL, Merritt JH, Murphy MR. 1999. Lack of effects on heart rate and blood pressure in ketamine-anesthetized rats briefly exposed to ultra-wideband electromagnetic pulses. IEEE Trans Biomed Eng 46:117-120.
24. Johansson C, Jackson DM, Svensson L. 1997. Nitric oxide synthase inhibition blocks phencyclidine-induced behavioural effects on prepulse inhibition and locomotor activity in the rat. Psychopharmacology 131:167-173.
25. Kavaliers M, Ossenkopp KP. 1985. Exposure to rotating magnetic fields alters morphine-induced behavioral responses in two strains of mice. Neuropharmacology 24:337-340.
26. Kavaliers M, Ossenkopp KP. 1986. Stress-induced opioid analgesia and activity in mice: inhibitory influences of exposure to magnetic fields. Psychopharmacology 89: 440-443.
27. Kavaliers M, Ossenkopp KP. 1988. Magnetic fields inhibit opioid-mediated "analgesic" behaviours of the terrestrial snail, Cepaea nemoralis. J Comp Physiol A 162:551-558.
28. Kavaliers M, Ossenkopp KP. 1993. Repeated naloxone treatments and exposures to weak 60-Hz magnetic fields have "analgesic" effects in snails. Brain Res 620:159-162.
29. Kavaliers M, Ossenkopp KP, Prato FS, Carson JJL. 1994. Opioid systems and the biological effects of magnetic fields. In: Frey AH, editor. On the nature of electromagnetic field interactions with biological systems. Austin, Texas: Landes. pp 181-194.
30. Kavaliers M, Choleris E, Prato FS, Ossenkopp KP. 1998. Evidence for the involvement of nitric oxide and nitric oxide synthase in the modulation of opioid-induced antinociception and the inhibitory effects of exposure to 60-Hz magnetic fields in the land snail. Brain Res 809: 50-57.
31. Lai H. 1994. Neurological effects of radiofrequency electromagnetic radiation. In: Lin JC, editor. Advances in electromagnetic fields in living systems. Vol 1. New York: Plenum. pp. 27-80.
32. Lu ST, Mathur SP, Akyel Y, Lee JC. 1999. Ultra-wideband electromagnetic pulses induced hypotension in rats. Physiol Behav 65:753-761.
33. Machelska H, Labuz D, Przewlocki R, Przewlocka B. 1997. Inhibition of nitric oxide synthase enhances antinociception mediated by mu, delta and kappa opioid receptors in acute and prolonged pain in the rat spinal cord. J Pharmacol Exp Ther 282:977-984.
34. Maren S. 1998. Effects of 7-nitroindazole, a neuronal nitric oxide synthase (nNOS) inhibitor, on locomotor activity and contextual fear conditioning in rats. Brain Res 804:155-158.
35. Miura M, Takayama K, Okada J. 1993. Increase in nitric oxide and cyclic GMP of rat cerebellum by radio frequency burst-type electromagnetic field radiation. J Physiol 461: 513-524.
36. G-nitro arginine methyl ester exhibits antinociceptive activity in the mouse. Br J Pharmacol 102:198-202.
37. Moore PK, Babbedge RC, Wallace P, Gaffen ZA, Hart SL. 1993. 7-nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol 108: 296-297.
38. G-nitro arginine methyl ester induced antinociception in mice: A role for serotonergic and adrenergic neurons. Gen Pharmacol 23:1177-1182.
39. Ossenkopp KP, Kavaliers M. 1987. Morphine-induced analgesia and exposure to low-intensity 60-Hz magnetic fields: inhibition of nocturnal analgesia in mice is a function of magnetic field intensity. Brain Res 418:356-360.
40. Papi F, Ghione S, Rosa C, Del Seppia C, Luschi P. 1995. Exposure to oscillating magnetic fields influences sensitivity to electrical stimuli. I. Experiments on humans. Bioelectromagnetics 16:294-300.
41. Pavone F, Capone F, Populin R, Przewlocka B. 1997. Nitric oxide synthase inhibitors enhance the antinociceptive effects of oxotremorine in mice. Pol J Pharmacol 49:31-36.
42. Prato FS, Kavaliers M, Ossenkopp KP, Carson JJL, Drost DJ, Frappier JRH. 1992. Extremely low frequency magnetic field exposure from MRI/MRS procedures. Ann NY Acad Sci 649:44-58.
43. Sakurada T, Sugiyama A, Sakurada C, Tan-No K, Yonezawa A, Sakurada S, Kensuke K. 1996. Effect of spinal nitric oxide inhibition on capsaicin-induced nociceptive response. Life Sci 59:921-930.
44. Sandi C, Venero C, Guaza C. 1995. Decreased spontaneous motor activity and startle response in nitric oxide synthase inhibitor-treated rats. Eur J Pharmacol 277:89-97.
45. Sartucci F, Bonfiglio L, Del Seppia C, Luschi P, Ghione S, Murri L, Papi F. 1997. Changes in pain perception and pain-related somatosensory evoked potentials in humans produced by exposure to oscillating magnetic fields. Brain Res 769: 362-366.
46. Seaman RL, Belt ML, Doyle JM, Mathur SP. 1998. Ultra-wideband electromagnetic pulses and morphine-induced changes in nociception and activity in mice. Physiol Behav 65:263-270.
47. Seaman RL, Kiel JL, Parker JE, Grubbs TR, Prol HK. 1996. Effects of ultra-wide-band pulses on nitric oxide production in murine macrophages. Abstracts of the Bioelectromagnetics Society Eighteenth Annual Meeting: 213.
48. Sherry CJ, Blick DW, Walters TJ, Brown GC, Murphy MR. 1995. Lack of behavioral effects in non-human primates after exposure to ultrawideband electromagnetic radiation in the microwave frequency range. Radiat Res 143:93-97.
49. Spinella M, Bodnar RJ. 1994. Nitric oxide synthase inhibition selectively potentiates swim stress antinociception in rats. Pharmacol Biochem Behav 47:727-733.
50. Thomas AW, Kavaliers M, Prato FS, Ossenkopp KP. 1997a. Antinociceptive effects of a pulsed magnetic field in the land snail, Cepaea nemoralis. Neurosci Lett 222:107-110.
51. Thomas AW, Kavaliers M, Prato FS, Ossenkopp KP. 1997b. Pulsed magnetic field induced "analgesia" in the land snail, Cepaea nemoralis, and the effects of μ, δ, and κ opioid receptor agonists/antagonists. Peptides 18:703-709.
52. Tysdale DM, Lipa SM, Ossenkopp KP, Kavaliers M. 1991. Inhibitory effects of 60-Hz magnetic fields on opiate-induced "analgesia" in the land snail, Cepaea nemoralis, under natural conditions. Physiol Behav 49:53-56.
53. Volke V, Soosaar A, Kõõks S, Bourin M, Männistúo PT, Vasar E. 1997. 7-Nitroindazole, a nitric oxide synthase inhibitor, has anxiolytic-like properties in exploratory models of anxiety. Psychopharmacology 131:399-405.
54. Walters TJ, Mason PA, Sherry CJ, Steffen C, Merritt JH. 1995. No detectable bioeffects following acute exposure to high peak power ultra-wide band electromagnetic radiation in rats. Aviat Space Environ Med 66:562-567.
55. G-nitro-L-arginine methyl ester (L-NAME) of resistance to venous return in rats. Br J Pharmacol 114:1454-1458.
56. ω-nitro l-arginine methyl ester on thermal nociceptive tests in the rat. Can J Anaesth 43:975-981.
57. G-nitro-L-arginine methyl ester. Int J Cancer 75:140-144.