The spiroketals containing a benzyloxymethyl moiety at C8 position showed the most potent apoptosis-inducing activity

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 14, 1999, Pages 2007-2012

  Mitsuhashi, Shinya ^a   Shima, Hiroshi ^a   Kawamura, Takeshi ^a   Kikuchi, Kunimi ^a   Oikawa, Masato ^a   Ichihara, Akitami ^a   Oikawa, Hideaki ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYL DERIVATIVE;

APOPTOSIS; ARTICLE; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STEREOSPECIFICITY;

APOPTOSIS; DNA FRAGMENTATION; HUMANS; JURKAT CELLS; LETHAL DOSE 50; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PYRANS; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033584156     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00309-1     Document Type: Article

References (8)

1. Riordan, F. A.; Foroni, L.; Hoffbrand, A. V.; Mehta, A. B.; Wickremasinghe, R. G. FEBS Lett. 1998, 435, 195-8.
2. Li, D. W.; Fass, U.; Huizar, I.; Spector, A. Eur. J. Biochem. 1998, 257, 351-61.
3. Kawamura, T.; Matsuzawa, S.; Mizuno, Y.; Kikuchi, K.; Oikawa, H.; Oikawa, M.; Ubukata, M.; Ichihara, A. Biochem. Pharmacol. 1998, 55, 995-1003.
4. Matsuzawa, S.; Kawamura, T.; Mitsuhashi, S.; Suzuki, T.; Matsuo, Y.; Suzuki, M.; Mizuno, Y.; Kikuchi, K. Bioorg. Med. Chem. 1999, 7, 381-387.
5. Yasumoto, T.; Murata, M.; Oshima, Y.; Sano, M.; Matsumoto, G. K.; Clardy, J. Tetrahedron 1985, 41, 1019-1025.
6. Vaux, D. L. Proc. Natl. Acad. Sci. U. S. A. 1993, 90, 786-9.
7. Oikawa, M.; Ueno, T.; Oikawa, H.; Ichihara, A. J. Org. Chem. 1995, 60, 5048-5068
8. Oikawa, M.; Oikawa, H,; Ichihara, A. Tetrahedron 1995, 51, 6237-6254