Convenient preparation of no-carrier-added technetium-99m radiopharmaceuticals using solid-phase technology

Bioconjugate Chemistry

Volumn 10, Issue 5, 1999, Pages 832-837

  Dunn Dufault, Robert ^a,b   Pollak, Alfred ^a   Thornback, John R ^a   Ballinger, James R ^b,c,d  

^a Resolution Pharmaceuticals Inc   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c PRINCESS MARGARET HOSPITAL   (Canada)

^d University Medical Imaging Centre   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHROMATOGRAPHY; PEPTIDES; TECHNETIUM;

AMINE GROUPS; AMINO ACID ANALYSIS; FUNCTIONALIZED; SOLID PHASIS; SOLID SUPPORTS; SOLID-PHASE; SPECIFIC ACTIVITY; TECHNETIUM-; TECHNETIUM-99M; TWO-STEP PROCESS;

CHELATION;

EID: 0033199928     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc990032f     Document Type: Article

References (18)

1. Babich, J. W., Solomon, H., Pike, M. C., Kroon, D., Graham, W., Abrams, M. J., Tompkins, R. G., Rubin, R. H., and Fishman, A. J. (1993) Technetium-99m-labeled hydrazino nicotinamide derivatized chemotactic peptide analogs for imaging focal sites of bacterial infection. J. Nucl. Med. 34, 1964-1974.
2. Fritzberg, A. R., Kasina, S., Eshima, D., and Johnson, D. L. (1986) Synthesis and biological evaluation of technetium-99m MAG3 as a hippuran replacement. J. Nucl. Med. 27, 111-116.
3. Goodbody, A., Ballinger, J., Tran, L., Sumner-Smith, M., Lau, F., Meghi, K., and Pollak, A. (1994) A new Tc-99m labelled penta-peptide inflammation imaging agent. Eur. J. Nucl. Med. 21, 870.
4. Caveliers, V., Goodbody, A., Tran, L., Bossuyt, A., and Thornback, J. (1996) Human dosimetry of TC99m-RP128, a potential inflammation imaging agent. Eur. J. Nucl. Med. 23, 1131.
5. Bodanszky, M., and Bodanszky, A. (1984) The Practice of Peptide Synthesis, Springer-Verlag, New York.
6. -: carrier free? J. Nucl. Med. 16, 639-641.
7. 99m/99Tc-DADT-benzovesamicol: a potential marker for cholinergic neurons. Nucl. Med. Biol. 21, 197-203.
8. DiZio, J. P., Fiaschi, R., Davison, A., Jones, A. G., and Katzenellenbogen, J. A. (1991) Progestin-rhenium complexes: metal-labeled steroids with high receptor binding affinity, potential receptor-directed agents for diagnostic imaging or therapy. Bioconjugate Chem. 2, 353-66.
9. DiZio, J. P., Anderson, C. J., Davison, A., Ehrhardt, G. J., Carlson, K E., Welch, M. J., and Katzenellenbogen, J. A. (1992) Technetium- and rhenium-labeled progestins: synthesis, receptor binding and in vivo distribution of an 11 beta-substituted progestin labeled with technetium-99 and rhenium-186. J. Nucl. Med. 33, 558-569.
10. Hirai, H. (1990) Use of tumor receptors for diagnostic imaging. A review. Acta Radiol. (Suppl.) 374, 57-64.
11. Kung, H. F., Kim, H. J., Kung, M. P., Meegalla, S. K., Plossl, K., and Lee, H. K. (1996) Imaging of dopamine transporters in humans with technetium-99m TRODAT-1. Eur. J. Nucl. Med. 23, 1527-1530.
12. Kung, H. F. (1991) Overview of radiopharmaceuticals for diagnosis of central nervous disorders. Crit. Rev. Clin. Lab. Sci. 28, 269-86.
13. 2-metal conjugate. Bioconjugate Chem. 5, 182-193.
14. Pearson, D. A., Lister-James, J., McBride, W. J., Wilson, D. M., Martel, L. J., Civitello, E. R., and Dean, R. T. (1996) Thrombus imaging using technetium-99m-labeled high-potency GPIIb/IIIa receptor antagonists. Chemistry and initial biological studies. J. Med. Chem. 39, 1372-1382.
15. Lever, S. Z., Baidoo, K. E., Mahmood, A., Matsumura, K., Scheffel, U., and Wagner, H. N. (1994) Novel technetium ligands with affinity for the muscarinic cholinergic receptor. Nucl. Med. Biol. 21, 157-164.
16. Kao, C. H., Baidoo, K. E., and Lever, S. Z. (1997) Validation and application of a solid-phase chemistry method for preparation of high effective specific activity technetium-99m radiopharmaceuticals. Nucl. Med. Biol. 24, 499-505.
17. Flanagan, R. J., Wilson, J. S., and Wiebe, L. I. (1986) A high speed, no-carrier-added radiochemical reactor for the synthesis of halogenated radiopharmaceuticals. J. Labelled Compd. Radiopharm. 23, 1242-1243.
18. Zhu, X., Gobi, J., and Hunter, D. H. (1998) A convenient preparation of no-carrier-added MIBG via solid-phase organic chemistry. J. Nucl. Med. 39, 143P.