Partial functional correction of xeroderma pigmentosum group A cells by suppressor tRNA

Human Gene Therapy

Volumn 10, Issue 13, 1999, Pages 2209-2219

  Panchal, Rekha G ^a   Wang, Suming ^a   McDermott, Jeffrey ^a   Link Jr , Charles J ^a  

^a Iowa Cancer Research Foundation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; DNA; MUTANT PROTEIN; TRANSFER RNA;

ARTICLE; CELL POPULATION; CELL SURVIVAL; FLUORESCENCE; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONSENSE MUTATION; PARTICLE SIZE; PATHOGENESIS; PHENOTYPE; PLASMID; PROTEIN ANALYSIS; RADIATION DOSE; RNA ANALYSIS; TRANSGENE; ULTRAVIOLET RADIATION; XERODERMA PIGMENTOSUM;

CELL LINE; CELL SURVIVAL; DNA-BINDING PROTEINS; GENE TRANSFER TECHNIQUES; HERPESVIRUS 1, HUMAN; HUMANS; POINT MUTATION; RNA, TRANSFER, ARG; SUPPRESSION, GENETIC; TRANSFECTION; ULTRAVIOLET RAYS; XERODERMA PIGMENTOSUM; XERODERMA PIGMENTOSUM GROUP A PROTEIN;

EID: 0033199744     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950017194     Document Type: Article

References (50)

1. ATKINSON, J., and MARTIN, R. (1994). Mutations to nonsense codons in human genetic disease: Implications for gene therapy by nonsense suppressor tRNAs. Nucleic Acids Res. 22, 1327-1334.
2. BOULIKAS, T. (1996). Xeroderma pigmentosum and molecular cloning of DNA repair genes. Anticancer Res. 16, 693-708.
3. BUCKLAND, R.A., MAULE, J.C., and SEALEY, P.G. (1996). A cluster of transfer RNA genes (TRM1, TRR3, and TRAN) on the short arm of human chromosome 6. Genomics 35, 164-171.
4. BULFIELD, G., SILLER, W.G., WIGHT, P.A.L., and MOORE, K.J. (1984). X chromosome-linked muscular dystrophy (mdx) in the mouse. Proc. Natl. Acad. Sci. U.S.A. 81, 1189-1192.
5. CAIRNS, C.A., and WHITE, R.J. (1998). p53 is a general repressor of RNA polymerase III transcription. EMBO J. 17, 3112-3123.
6. CAPONE, J.P., SHARP, P.A., and RAJBHANDARY, U.L. (1985). Amber, ochre and opal suppressor tRNA genes derived from a human serine tRNA gene. EMBO J. 4, 213-221.
7. CARREAU, M., QUILLIET, X., EVENO, E., SALVETTI, A., DANOS, O., HEARD, J.-M., MEZZINA, M. and SARASIN, A. (1995). Functional retroviral vector for gene therapy of xeroderma pigmentosum group D patients. Hum. Gene Ther. 6, 1307-1315.
8. CLEAVER, J.E. (1968). Defective repair replication of DNA in xeroderma pigmentosum. Nature (London) 218, 652-656.
9. CLEAVER, J.E., and KRAEMER, A.L. (1989). In The Metabolic Basis of Inherited Disease, vol. II. C.R. Scriver, A.L. Beaudet, W.S. Sly, and D. Valle, eds. (McGraw-Hill, New York) pp. 2949-2971.
10. COPELAND, N.E., HANKE, C.W., and MICHALAK, J.A. (1997). The molecular basis of xeroderma pigmentosum. Dermatol. Surg. 23, 447-455.
11. DORIN, J.R., FARLEY, R., WEBB, S., SMITH, S.N., FARINI, E., DELANEY, S.J., WAINWRIGHT, B.J., ALTON, E.W., and PORTEOUS, D.J. (1996). A demonstration using mouse models that successful gene therapy for cystic fibrosis requires only partial gene correction. Gene Ther. 3, 797-801.
12. FRAEFEL, C., SONG, S., LIM, F., LANG, P., YU, L., WANG, Y., WILD, P., and GELLER, A.I. (1996). Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells. J. Virol. 70, 7190-7197.
13. GOZUKARA, E.M., PARRIS, C.N., WEBER, C.A., SALAZAR, E.P., SEIDMAN, M.M., WATKINS, J.F., PRAKASH, L., and KRAEMER, K.H. (1994). The human DNA repair gene, ERCC2 (XPD), corrects ultraviolet hypersensitivity and ultraviolet hypermutability of a shuttle vector replicated in xeroderma pigmentosum. Cancer Res. 54, 3837-3844.
14. HANAWALT, P.C. (1995). DNA repair comes of age. Mutat. Res. 336, 101-113.
15. HARDWICKE, M.A., and SANDRI-GOLDIN, R.M. (1994). The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infection. J. Virol. 68, 4797-4810.
16. HATFIELD, D.L., SMITH, D.W., LEE, B.J., WORLAND, B.J. and OROSZLAN, S. (1990). Structure and function of suppressor tRNAs in higher eukaryotes. Crit. Rev. Biochem. Mol. Biol. 25, 71-96.
17. HUDZIAK, R.M., LASKI, F.A., RAJBHANDARY, U.L., SHARP, P.A., and CAPECCHI, M.R. (1982). Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes. Cell 31, 137-146.
18. KRAEMER, K.H., PROTIC-SABLJIC, M., BREDBERG, A., and SEIDMAN, M.M. (1987). Plasmid vectors for study of DNA repair and mutagenesis. Curr. Prob. Dermatol. 17, 166-181.
19. KUCHINO, Y. and MURAMATSU, T. (1996). Nonsense suppression in mammalian cells. Biochimie 78, 1007-1015.
20. KWONG, A.D., KRUPER, J.A., and FRENKEL, N. (1988). Herpes simplex virus host shutoff function. J. Virol. 62, 912-921.
21. LAMBERT, C., COUTO, L.B., WEISS, W.A., SCHULTZ, R.A., THOMPSON, L.H., and FRIEDBERG, E.C. (1988). A yeast DNA repair gene partially complements defective excision repair in mammalian cells. EMBO J. 7, 3245-3253.
22. LARMINIE, C.G.C., CAIRNS, C.A., MITAL, R., MARTIN, K., KOUZARIDES, T., JACKSON, S.P., and WHITE, R.J. (1997). Mechanistic analysis of RNA polymerase III regulation by the retinoblastoma protein. EMBO J. 16, 2061-2071.
23. LASKI, F.A., BELAGAJE, R., RAJBHANDARY, U.L., and SHARP, P.A. (1982). An amber suppressor tRNA gene derived by site-specific mutagenesis: Cloning and function in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 79, 5813-5817.
24. LASKI, F.A., BELAGAJE, R., HUDZIAK, R.M., CAPECCHI, M.R., NORTON, G.P., PALESE, P., RAJBHANDARY, U.L., and SHARP, A.P. (1984). Synthesis of an ochre suppressor tRNA gene and expression in mammalian cells. EMBO J. 3, 2445-2452.
25. LE GOFF, X., PHILIPPE, M., and JEAN-JEAN, O. (1997). Overexpression of human release factor 1 alone has an antisuppressor effect in human cells. Mol. Cell. Biol. 17, 3164-3172.
26. LEVY, D.D., SAIJO, M., TANAKA, K., and KRAEMER, K.H. (1995). Expression of a transfected DNA repair gene (XPA) in xeroderma pigmentosum group A cells restores normal DNA repair and mutagenesis of UV-treated plasmids. Carcinogenesis 16, 1557-1563.
27. LEVY, J.P., MULDOON, R.R., ZOLOTUKIN, S., and LINK, C.J. (1996). Retroviral transfer and expression of humanized, red shifted green fluorescent protein into human tumor cells. Nature Biotechnol. 14, 610-614.
28. LI, K., ZHANG, J., BUVOLI, M., YAN, X.D., LEINWAND, L., and HE, H. (1997). Ochre suppressor transfer RNA restored dystrophin expression in MDX mice. Life Sci. 61, 205-209.
29. MEZZINA, M., EVENO, E., CHEVALLIER-LAGENTE, O., BENOIT, A., CARREAU, M., VERMEULEN, W., HOEIJMAKERS, J.H.J., STEFANINI, M., LEHMANN, A.R., WEBER, C.A., and SARASIN, A. (1994). Correction by the ERCC2 gene of UV sensitivity and repair deficiency phenotype in a subset of trichothiodystrophy cells. Carcinogenesis 15, 1493-1498.
30. MURGOLA, E.J. (1990). Suppression and the genetic code: Beyond codons and anticodons. Experientia 46, 1134-1141.
31. NISHIGORI, C., MORIWAKI, S.-I., TAKEBE, H., TANAKA, T., and IMAMURA, S. (1994). Gene alterations and clinical characteristics of xeroderma pigmentosum group A patients in Japan. Arch. Dermatol. 130, 191-197.
32. PHILLIPS-JONES, M.K., WATSON, F.J., and MARTIN, R. (1993). The 3′ codon context effect on UAG suppressor tRNA is different in Escherichia coli and human cells. J. Mol. Biol. 233, 1-6.
33. PHILLIPS-JONES, M.K., HILL, L.S.J., ATKINSON, J., and MARTIN, R. (1995). Context effects on misreading and suppression at UAG codons in human cells. Mol. Cell. Biol. 15, 6593-6600.
34. QUILLIET, X., CHEVALLIER-LAGENTE, O., EVENO, E., STOJKOVIC, T., DESTEE, A., SARASIN, A., and MEZZINA, M. (1996). Long-term complementation of DNA repair deficient human primary fibroblasts by retroviral transduction of the XPD gene. Mutat. Res. 364, 161-169.
35. SATOKATA, I., TANAKA, K., MIURA, N., MIYAMOTO, I., SATOH, Y., KONDO, S., and OKADA, Y. (1990). Characterization of a splicing mutation in group A xeroderma pigmentosum. Proc. Natl. Acad. Sci. U.S.A. 87, 9908-9912.
36. SATOKATA, I., TANAKA, K., MIURA, N., NARITA, M., MIMAKI, T., SATOH, Y., KONDO, S., and OKADA, Y. (1992a). Three nonsense mutations responsible for group A xeroderma pigmentosum. Mutat. Res. 273, 193-202.
37. SATOKATA, I., TANAKA, K., and OKADA, Y. (1992b). Molecular basis of group A xeroderma pigmentosum: A missense mutation and two deletions located in a zinc finger consensus sequence of the XPAC gene. Hum. Genet. 88, 603-607.
38. SATOKATA, I., TANAKA, K., YUBA, S., and OKADA, Y. (1992c). Identification of splicing mutations of the last nucleotides of exons a nonsense mutation and a missense mutation of the XPAC gene as causes of group A xeroderma pigmentosum. Mutat. Res. 273, 203-212.
39. SATOKATA, I., IWAI, K., MATSUDA, T., OKADA, Y., and TANAKA, K. (1993). Genomic characterization of the human DNA excision repair-controlling gene XPAC. Gene 136, 345-348.
40. SHIMAMOTO, T., TANIMURA, T., YONEDA, Y., KOBAYAKAWA, Y., SUGASAWA, K., HANAOKA, F., OKA, M., OKADA, Y., TANAKA, K., and KOHNO, K. (1995). Expression and functional analyses of the Dxpa gene the Drosophila homolog of the human excision repair gene XPA. J. Biol. Chem. 270, 22452-22459.
41. SICINSKI, P., GENG, Y., RYDER-COOK A.S., BARNARD, E.A., DARLISON, M.G., and BARNARD, P.J. (1989). The molecular basis of muscular dystrophy in the mdx mouse: A point of mutation. Science 244, 1578-1580.
42. SPAETE, R.R., and FRENKEL, N. (1982). The herpes simplex virus amplicon: A new eukaryotic defective-virus cloning-amplifying vector. Cell 30, 295-304.
43. TANAKA, K., SATOKATA, I., OGITA, Z., UCHIDA, T., and OKADA, Y. (1989). Molecular cloning of a mouse DNA repair gene that complements the defect of group-A xeroderma pigmentosum. Proc. Natl. Acad. Sci. U.S.A. 86, 5512-5516.
44. TANAKA, K., MIURA, N., SATOKATA, I., MIYAMOTO, I., YOSHIDA, M.C., SATOH, Y., KONDO, S., YASUI, A., OKAYAMA, H., and OKADA, Y. (1990). Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain. Nature (London) 348, 73-78.
45. TEMPLE, G.F., DOZY, A.M., ROY, K.L., and KAN, W.Y. (1982). Construction of a functional human suppressor tRNA gene: An approach to gene therapy for β-thalassaemia. Nature (London) 296, 537-540.
46. WANG, S., and VOS, J. (1996). A hybrid infectious vector based on Epstein-Barr virus and herpes simplex virus type I for gene transfer into human gene. J. Virol. 70, 8422-8430.
47. WANG, S., YOUNG, W.-B., JACOBSON, C., and LINK, C.J. (1997). A novel herpesvirus amplicon system for in vivo gene therapy. Gene Ther. 4, 1132-1141.
48. WHITE, R.J. (1997). Regulation of RNA polymerases I and III by the retinoblastoma protein: A mechanism for growth control. Trends Biol. Sci. 22, 77-80.
49. YAGI, T., MATSUMMURA, Y., SATO, M., NISHIGORI, C., MORI, T., SUBERS, A.M., and TAKEBE, H. (1998). Complete restoration of normal DNA repair characteristics in group F xeroderma pigmentosum cells by over-expression of transfeced XPF cDNA. Carcinogenesis 19, 55-60.
50. ZENG, L., QUILLIET, X., CHEVALLIER-LAGENTE, O., EVENO, E., SARASIN, A., and MEZZINA, M. (1997). Retrovirus-mediated gene transfer corrects DNA repair defect of xeroderma pigmentosum cells of complementation groups A, B and C. Gene Ther. 4, 1077-1084.