Only a small portion of the cytoplasmic progesterone receptor is associated with Hsp90 in vivo

Journal of Cellular Biochemistry

Volumn 74, Issue 3, 1999, Pages 458-467

  Passinen, Satu ^a   Haverinen, Marjaana ^a   Pekki, Anu ^a   Rauta, Jenita ^a   Paranko, Jorma ^a   Syvälä, Heimo ^a   Tuohimaa, Pentti ^a   Ylikomi, Timo ^a,b,c  

^a UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

Hsp90; Progesterone receptor

Indexed keywords

CYTOPLASMIC RECEPTOR; HEAT SHOCK PROTEIN 90; MUTANT PROTEIN; OLIGOMER; PROGESTERONE RECEPTOR; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL FRACTIONATION; COMPLEX FORMATION; CYTOPLASM; MONKEY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

ANIMALS; COS CELLS; CYTOPLASM; HSP90 HEAT-SHOCK PROTEINS; MOLYBDENUM; OXIDATIVE STRESS; PROTEIN BINDING; RECEPTORS, PROGESTERONE;

EID: 0033198072     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19990901)74:3<458::AID-JCB13>3.0.CO;2-M     Document Type: Article

References (39)

1. Alexis MN, Mavridou I, Mitsiou DJ. 1992. Subunit composition of the untransformed glucocorticoid receptor in the cytosol and in the cell. Eur J Biochem 204:75-84.
2. Alnemri ES, Litwack G. 1993. The steroid binding domain influences intracellular solubility of the baculovirus over-expressed glucocorticoid and mineralocorticoid receptors. Biochemistry 32:5387-5393.
3. Baulieu EE. 1989. Contragestion and other clinical applications of RU 486, an antiprogesterone at the receptor. Science 245:1351-1357.
4. Bohen SP, Kralli A, Yamoto KR. 1995. Hold'em and fold'em: Chaperones and signal transduction. Science 268:1303-1304.
5. Bresnick EH, Dalman FC, Pratt WB. 1990. Direct stoichiometric evidence that the untransformed Mr 300 000, 9S, glucocorticoid receptor is a core unit derived from a larger heteromeric complex. Biochemistry 29:520-527.
6. Carson-Jurica MA, Lee AT, Dobson AW, Conneely OM, Schrader WT, O'Malley BW. 1989. Interaction of the chicken progesterone receptor with heat shock protein (hsp) 90. J Steroid Biochem 34:1-9.
7. Chambraud B, Berry M, Redeuilh G, Chambon P and Baulieu EE. 1990. Several regions of human estrogen receptor are involved in the formation of receptor-heat shock protein-90 complexes. J Biol Chem 265:20686-20691.
8. Dalman FC, Koenig RJ, Perdew GH, Massa E, Pratt WB. 1990. In contrast to the glucocorticoid receptor, the thyroid hormone receptor is translated in the DNA binding state and is not associated with hsp90. J Biol Chem 265:3615-3618.
9. Dalman FC, Sturzenbecker LJ, Levin AA, Lucas AD, Perdew GH, Petkovitch M, Chambon P, Grippo JF, Pratt WB. 1991. Retinoic acid receptor belongs to a subclass of nuclear receptors that do not form docking complexes with hsp90. Biochemistry 30:5605-5608.
10. Dougherty JJ, Puri RK, Toft DO. 1984. Polypeptide components of two 8S forms of chicken oviduct progesterone receptor. J Biol Chem 259:8004-8009.
11. Freeman BC, Toft DO, Morimoto RI. 1996. Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23. Science 274:1718-1720.
12. Grody WW, Schrader WT, O'Malley BW. 1982. Activation, transformation and subunit structure of steroid hormone receptors. Endocr Rev 3:141-162.
13. Gronemeyer H, Laudet V. 1995. Transcription factors 3: Nuclear receptors. Protein profile Volume 2. New York: Academic Press.
14. Groyer A, Schweizer-Groyer G, Cadepond F, Mariller M, Baulieu EE. 1987. Antiglucocorticosteroid effects suggest why steroid hormone is required for receptors to bind DNA in vivo but not in vitro. Nature 328:624.
15. Guiochon-Mantel A, Lescop P, Cristinmaitre S, Loosfelt H, Perrot-Applanat M, Milgrom E. 1991. Nucleocytoplasmic shuttling of the progesterone receptor. EMBO J 10:3851-3859.
16. Hansen JC, Gorski J. 1985. Conformational and eletrostatic propereties of unoccupied and liganded estrogen receptors determined by aquous two-phase partitioning. Biochemistry 24:6078-6085.
17. Kang KI, Devin J, Cadepond F, Jibard N, Guichon-Mantel A, Baulieu ET, Catelli AM. 1994. In vivo functional protein-protein interaction:nuclear targeted hsp90 shifts sytoplasmic steroid receptor mutants into the nucleus. Proc Natl Acad Sci USA 91:340-344.
18. Nair SC, Toran EJ, Rimerman RA, Hjermstad S, Smithgall TE, Smith DF. 1996. A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor. Cell Stress Chaperones 1:237-250.
19. Nishigori H, Toft D. 1980. Inhibition of progesterone receptor activation by sodium molybdate. Biochemistry 19: 77-83.
20. Pekki AK. 1991. Different immunoelectron microscopic locations of progesterone receptor and hsp90 in chick oviduct epithelial cells. J Histochem Cytochem 39:1095-1101.
21. Pekki A, Ylikomi T, Syvälä H, Tuohimaa P. 1995. Progesterone receptor does not form oligomeric (8S), non-DNA-binding complex in intact cell nuclei. J Cell Biochem 58:1-10.
22. Raaka BM, Finnerty M, Sun E, Samuels HH. 1985. Effects of Molybdate on steroid receptors in intact GH1 cells. J Biol Chem 260:14009-14015.
23. Rexin M, Busch W, Gehring U. 1991. Protein components of the nonactivated glucocorticoid receptor. J Biol Chem 266:24601-24605.
24. Rossini GP, Camelli L. 1994. Oligomeric structures of cytosoluble estrogen-receptor complexes as studied by antiestrogen receptor antibodies and chemical crosslinking of intact cells. J Steroid Biochem Mol Biol 50:241-252.
25. Schowalter DB, Sullivan WP, Maihle NJ, Dobson ADW, Conneely OM, O'Malley BW, Toft DO. 1991. Characterization of progesterone receptor binding to the 90-and 70-kDa heat shock proteins. J Biol Chem 266:21165-21173.
26. Segnitz B, Gehring U. 1995. Subunit structure of the nonactivated human estrogen receptor. Proc Natl Acad Sci USA 92:2179-2183.
27. Smith DF, Schowalter DB, Kost SL, Toft DO. 1990. Reconstitution of progesterone receptor with heat shock proteins. Mol Endocrin 4:1704-1711.
28. Smith DF, Toft DO. 1993. Steroid receptors and their associated proteins. Mol Endocrinol 7:4-11.
29. Stancato LF, Hutchison KA, Krishna P, Pratt WB. 1996. Animal and plant cell lysates share a conserved chaperone system that assembles the glucocorticoid receptor into a functional heterocomplex with hsp90. Biochemistry 35:554-461.
30. Tienrungroj W, Meshinchi S, Sanchez ER, Pratt SE, Grippo JF, Holmgren A, Pratt WB. 1987. The role of sulfhydryl groups in permitting transformation and DNA binding of the glucocorticoid receptor. J Biol Chem 262:6992-7000.
31. Toft D, Gorski J. 1966. A receptor molecule for estrogens: Isolation from the rat uterus and preliminary characterization. Proc Natl Acad Sci USA 55:1574-1581.
32. Tuohimaa P, Pekki A, Bläuer M, Joensuu T, Vilja P, Ylikomi T. 1993. Nuclear progesterone receptor is mainly hsp90-free in vivo. Proc Natl Acad Sci USA 90:5848-5852.
33. Turcotte B, Meyer ME, Bocquel MT, Belanger L, Chambon P. 1990. Repression of the alpha fetoprotein gene promoter by progesterone and chimeric receptors in the presence of hormones and anti-hormones. Mol Cell Biol 10:5002-5006.
34. Whitfield GK, Hsieh JC, Nakajima S, MacDonald PN, Thompson PD, Jurutka PW, Haussler CA, Haussler MR. 1995. A highly conserved region in the hormone-binding domain of the human vitamin D receptor contains residues vital for heterodimerization with retinoid X receptor and for transcriptional activation. Mol Endocrinol 9:1166-1179.
35. Wikstöm AC, Bakke O, Okret S, Brönnegård M, Gustafsson JÅ. 1987. Intracellular localization of the glucocorticoid receptor evidence for cytoplasmic and nuclear localization. Endocrinology 120:1232-1242.
36. Wurtz JM, Bourguet W, Renaud JP, Vivat V, Chambon P, Moras D, Gronemeyer H. 1996. A canonical structure forthe ligand-binding domain of nuclear receptors. Nat Struct Biol 3:87-94.
37. Yang J, Defranco DB. 1996. Assessment of glucocorticoid receptor-heat shock protein90 interactions in vivo during nucleocytoplasmic trafficking. Mol Endocrin 10:3-13.
38. Ylikomi T, Bocquel MT, Berry M, Gronemeyer H, Chambon P. 1992. Cooperation of protosignals for nuclear accumulation of estrogen and progesterone receptors. EMBO J 11:3681-3694.
39. Ylikomi T, Wurtz J-M, Syvälä H, Passinen S, Pekki A, Haverinen M, Bläuer M, Tuohimaa P, Gronemeyer H. 1998. Reappraisal of the role of heat schock proteins as regulators of steroid receptor activity. Crit Rev Biochem Mol Biol 33:437-466.