The clinical significance of core promoter and precore mutations during the natural course and interferon therapy in patients with chronic hepatitis B

American Journal of Gastroenterology

Volumn 94, Issue 8, 1999, Pages 2237-2245

  Shindo, Michiko ^a   Hamada, Kazushige ^a   Susumu Koya, Yoshihiro Sokawa ^a   Okuno, Tadao ^b  

^a Akashi Municipal Hospital   (Japan)

^b KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; AMINOTRANSFERASE; GAMMA INTERFERON; HEPATITIS B(E) ANTIBODY; HEPATITIS B(E) ANTIGEN; MEMBRANE ANTIGEN; RECOMBINANT ALPHA2B INTERFERON;

ADOLESCENT; ADULT; AMINO ACID SUBSTITUTION; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; DNA SEQUENCE; ENZYME ACTIVITY; FEMALE; GENE MUTATION; HEPATITIS B; HUMAN; HYPOTHESIS; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALE; MOLECULAR CLONING; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; STOP CODON; TREATMENT OUTCOME;

EID: 0033179722     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1572-0241.1999.01299.x     Document Type: Article

References (29)

1. Hoofnagle JH, Shafritz DA, Popper H. Chronic type B hepatitis and the "healthy" HBsAg carrier state. Hepatology 1987; 7:758-63.
2. Realdi G, Alberti A, Rugge M, et al. Seroconversion from hepatitis B e antigen to antibody in chronic type B hepatitis. Gastroenterology 1980;79:195-9.
3. Hoofnagle JH, Dusheiko GM, Seeff LB, et al. Seroconversion from hepatitis B e antigen to antibody in chronic type B hepatitis. Ann Intern Med 1981;94:744-8.
4. Garcia PD, Ou J-H, Rutter WJ, et al. Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane after signal peptide cleavage translocation can be aborted and the product released into the cytoplasm. J Cell Biol 1988;106:1093-1104.
5. Standring DN, Ou J-H, Masiarz FR, et al. A signal peptide encoded within the precore region of hepatitis B virus directs the secretion of a heterogenous population of e antigens in xenopus oocyte. Proc Natl Acad Sci USA 1988;85:8405-9.
6. Carman WF, Jacyna MR, Hadziyannis S, et al. Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet 1989;2:588-90.
7. Okamoto H, Yotsumoto S, Akahane Y, et al. Hepatitis B virus with precore region defects prevail in persistently infected hosts along with Seroconversion to the antibody against e antigen. J Virol 1990;64:1298-1303.
8. Brunetto MR, Giarin MM, Liveri F, et al. Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis. Proc Natl Acad Sci USA 1991;88:4180-90.
9. Kosaka Y, Takase K, Kojima M, et al. Fulminant hepatitis B: Induction by hepatitis B virus mutants defective in the precore region and incapable of encoding e antigen. Gastroenterology 1991:100:1087-94.
10. Carman WF, Pagan EA, Hadziyannis S, et al. Association of a precore genomic variants of hepatitis B virus with fulminant hepatitis. Hepatology 1991;14:31-5.
11. Omata M, Ebata T, Yokosuka O, et al. Mutations in the precore region of hepatitis B virus DNA in patients with fulminant hepatitis. N Engl J Med 1991:324:1699-1704.
12. Laskus T, Persing DH, Nowicki MJ, et al. Nucleotide sequence analysis of the precore region in patients with fulminant hepatitis B in the United States. Gastroenterology 1993; 105:1173-8.
13. Ferray C, Gigou M, Samuel D, et al. Low prevalence of precore mutations in hepatitis B virus DNA in fulminant hepatitis type B in France. J Hepatol 1993;18:119-22.
14. Takeda K, Akahane Y, Suzuki H, et al. Defects in the precore region of the HBV genome in patients with chronic hepatitis B after sustained seroconversion from HBeAg to anti-HBe induced spontaneously or with interferon therapy. Hepatology 1990:12:1284-9.
15. Hamasaki K, Nakata K, Nagayama K, et al. Changes in the prevalence of HBeAg-negative mutant hepatitis B virus during the course of chronic hepatitis. Hepatology 1994;20:8-14.
16. Sato S, Suzuki K, Akahane Y, et al. Hepatitis B virus strains with mutations in the core promoter in patients with fulminant hepatitis. Ann Intern Med 1995:122:241-8.
17. Laskus T, Rakela J, Nowicki MJ, et al. Hepatitis B virus core promoter sequence analysis in fulminant and chronic hepatitis B. Gastroenterology 1995:109:1618-23.
18. Sterneck M, Gunter S, Santantonio T, et al. Hepatitis B virus genomes of patients with fulminant hepatitis do not share a specific mutation. Hepatology 1996;24:300-6.
19. 1764) of hepatitis B virus: Clinical significance and an easy method for detection. J Gen Virol 1995;76:3159-64.
20. Buckwold VE, Xu Zhichang, Chen M, et al. Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J Virol 1996;70:5845-51.
21. Wong DKH, Cheung AM, Keith O'Rourke MBA. Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B. A meta-analysis. Ann Intern Med 1993;119:312-23.
22. Gunther S, Meisel H, Reip A, et al. Frequent and rapid emergence of mutated pre-core sequences in HBV from e antigen positive carriers who seroconvert to anti-HBe during Interferon treatment. Virology 1992;187:271-9.
23. Laskus T, Rakela J, Persing DH. Nucleotide sequence analysis of precore and proximal core regions in patients with chronic hepatitis B treated with interferon. Dig Dis Sci 1995;40:l-7.
24. Bozkaya H, Ayola B, Lok ASF. High rate of mutations in the hepatitis B core gene during the immune clearance phase of chronic hepatitis B virus infection. Hepatology 1996;24:32-7.
25. Lok ASF, Akarla US, Greene S. Predictive value of precore hepatitis B virus mutations in spontaneous and interferoninduced hepatitis B e antigen clearance. Hepatology 1995;21: 19-24.
26. Zaaijer HL, ter Borg F, Cuypers HTM, et al. Comparison of methods for detection of hepatitis B virus DNA. J Clin Microbiol 1994:32:2088-91.
27. Haliassos A, Chomel JC, Tesson L, et al. Modification of enzymatically amplified DNA for the detection of point mutations. Nucleic Acids Res 1989;17:3606.
28. Okamoto H, Tsuda F, Sakugawa H, et al. Typing hepatitis B virus by homology in nucleotide sequence: Comparison of surface antigen subtypes. J Gen Virol 1988;69:2575-83.
29. Vaudin M, Wolstenholme AJ, Tsiquaye KN, et al. The complete nucleotide sequence of the genome of a hepatitis B virus isolated from a naturally infected chimpanzee. J Gen Virol 1988:69:1383-9.