Effect of long-term ACE inhibition on myocardial tissue in hypertensive stroke-prone rats

Journal of Molecular and Cellular Cardiology

Volumn 31, Issue 8, 1999, Pages 1447-1456

  Zimmermann, René ^a   Kastens, Jens ^b   Linz, Wolfgang ^c   Wiemer, Gabriele ^c   Schölkens, Bernward A ^c   Schaper, Jutta ^b  

^a KERCKHOFF HEART CENTER   (Germany)

^b MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^c SANOFI   (France)

Author keywords

ACE inhibitors; Fibrosis; Gene expression; Hypertension; Hypertrophy; VEGF

Indexed keywords

ALPHA ACTININ; CD45 ANTIGEN; COLLAGEN; COLLAGEN TYPE 1; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FIBRONECTIN; GROWTH FACTOR; MESSENGER RNA; RAMIPRIL; SCLEROPROTEIN; STRUCTURAL PROTEIN; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN; VIMENTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; HEART MUSCLE; HEART VENTRICLE HYPERTROPHY; IMMUNOHISTOCHEMISTRY; INFLAMMATORY INFILTRATE; LONG TERM CARE; MALE; NONHUMAN; NORTHERN BLOTTING; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

EID: 0033179154     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1999.0976     Document Type: Article

References (42)

1. Bauer EP, Kuki S, Arras M, Zimmermann R, Schaper W, 1996. Gene expression after pulmonary artery banding in pig hearts. Thorac Cardiovasc Surg 44: 181.
2. Bauer EP, Kuki S, Arras M, Zimmermann R, Schaper W, 1997. Increased growth factor transcription after pulmonary artery banding. Eur J Cardio-Thorac Surg 11: 818-823.
3. Berse B, Brown LF, Water LVD, Dvorak HF, Senger DR, 1992. Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol Biol Cell 3: 211-220.
4. Brooks WW, Bing OHL, Conrad CH, O'Neill L, Crow MT, Lakatta EG, Dostal DE, Baker KM, Boluyt MO, 1997. Captopril modifies gene expression in hypertrophied and failing hearts of aged spontaneously hypertensive rats. Hypertension 30: 1362-1368.
5. Carroll SM, Nimmo LE, Knoepfler PS, White FC, Bloor CM, 1995. Gene expression in a swine model of right ventricular hypertrophy: Intercellular adhesion molecule, vascular endothelial growth factor and plasminogen activators are upregulated during pressure overload. J Mol Cell Cardiol 27: 1427-1441.
6. Chapman D, Weber KT, Eghbali M, 1990. Regulation of fibrillar collagen types I and III and basement membrane type IV collagen gene expression in pressure overloaded rat myocardium. Circ Res 67: 787-794.
7. Chin K, Kurashima Y, Ogura T, Tajiri H, Yoshida S, Esumi H, 1997. Induction of vascular endothelial growth factor by nitric oxide in human glioblastoma and hepatocellular carcinoma cells. Oncogene 15: 437-442.
8. Chomczynski P, Sacchi N, 1987. Single step method of RNA isolation by acid guanidinium thiocyanatephenol-chloroform extraction. Anal Bioch 162: 156-159.
9. Conolly DT, Heuvelman DM, Nelson R, Olander JV, Eppley BL, Delfino JJ, Siegel NR, Leimgruber RM, Feder J, 1989. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J Clin Invest 84: 1470-1478.
10. Gohlke P, Linz W, Scholkens B, van Ewen P, Mantorana P, Unger T, 1996. Vascular and cardiac protection by ramipril in spontaneously hypertensive rats: Prevention versus regression study. Br J Clin Practice 84: 1-10.
11. Gohlke P, Kuwer I, Schnell A, Amann K, Mall G, Unger T, 1997. Blockade of bradykinin B2 receptors prevents the increase in capillary density induced by chronic angiotensin-converting enzyme inhibitor treatment in stroke-prone spontaneously hypertensive rats. Hypertension 29: 478-482.
12. Harrap SB, Mirakian C, Datodi SR, Lever AF, 1994. Blood pressure and lifespan following brief ACE inhibitor treatment in young spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 21: 125-127.
13. Horowitz JR, Rivard A, van der Zee R, Hariawala M, Sheriff DD, Esakof DD, Chaudhry GM, Symes JF, Isner JM, 1997. Vascular endothelial growth factor/vascular permeability factor produces nitric oxide-dependent hypotension: Evidence for a maintenance role in quiescent adult endothelium. Arterioscler Thromb Vasc Biol 17: 2793-2800.
14. Ignotz RA, Massague J, 1986. Transforming growth factor-β stimulates the expression of fibronectin and collagen and their incorporation in the extracellular matrix. J Biol Chem 261: 4337-4345.
15. Keck PJ, Hauser SD, Krivi G, Sanzo K, Warren T, Feder J, Connolly DT, 1989. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246: 1309-1312.
16. Kim S, Ohta K, Hamaguchi A, Yukimura T, Miura K, Iwao H, 1995a. Angiotensin II induces cardiac phenotypic modulation and remodeling in vivo in rats. Hypertension 25: 1252-1259.
17. Kim S, Kawamura M, Wanibuchi H, Ohta K, Hamaguchi A, Omura T, Yukimura T, Miura K, Iwao H, 1995b. Angiotensin II type 1 receptor blockade inhibits the expression of immediate-early genes and fibronectin in rat injured artery. Circulation 92: 88-95.
18. Kim S, Ohta K, Hamaguchi A, Omura T, Yukimura T, Miura K, Inada Y, Ishimura Y, Chatani F, Iwao H, 1995c. Angiotensin type I receptor antagonist inhibits the gene expression of transforming growth factor-beta 1 and extracellular matrix in cardiac and vascular tissues of hypertensive rats. J Pharmacol Exp Ther 273: 509-515.
19. Lee RMKW, Delaney KH, Lu M, 1995. Perindopril treatment prolonged the lifespan of spontaneously hypertensive rats. J Hypertens 13: 471-476.
20. Li J, Brown LF, Hibberd MG, Grossman JD, Morgan JP, Simons M, 1996. VEGF, flk-1, flt-1 expression in a rat myocardial infarction model of angiogenesis. Am J Physiol 270: H1803-H1811.
21. Li J, Hampton T, Morgan JP, Simons M, 1997. Stretch-induced VEGF expression in the heart. J Clin Invest 100: 18-24.
22. Linz W, Schaper J, Wiemer G, Albus U, Schölkens BA, 1992. Ramipril prevents left ventricular hypertrophy with myocardial fibrosis without blood pressure reduction: A one year study in rats. Br J Pharmacol 107: 970-975.
23. Linz W, Wiemer G, Schaper J, Zimmermann R, Nagasawa K, Gohlke P, Unger T, Schölkens BA, 1995. Angiotensin converting enzyme inhibitors, left ventricular hypertrophy and fibrosis. Mol Cell Biochem 147: 89-97.
24. Linz W, Jessen T, Becker RHA, Schölkens BA, Wiemer G, 1997. Long-term angiotensin converting enzyme inhibition doubles lifespan of hypertensive rats. Circulation 96: 3164-3172.
25. Murohara T, Asahara T, Silver M, Bauters C, Masuda H, Kalka C, Kearney M, Chen D, Symes JF, Fishman MC, Huang PL, Isner JM, 1998a. Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. J Clin Invest 101: 2567-2578.
26. Murohara T, Horowitz JR, Silver M, Tsurumi Y, Chen D, Sullivan A, Isner JM, 1998b. Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin. Circulation 97: 99-107.
27. Nagasawa K, Zimmermann R, Münkel B, Linz W, Schölkens B, Schaper J, 1995. Extracellular matrix deposition in hypertensive hearts - Antifibrotic effects of ramipril. Eur Heart J 16 (Suppl. C): 33-37.
28. Ogawa T, Linz W, Stevenson M, Bruneau BG, Kuroski de Bold ML, Chen JH, Eid H, Scholkens BA, De Bold AJ, 1996. Evidence for load-dependent and load-independent determinants of cardiac natriuretic peptide production. Circulation 93: 2059-2067.
29. 1 expression in hypertensive rats. Eur J Pharmacol 269: 115-119.
30. Parenti A, Morbidelli L, Cui X-L, Douglas JG, Hood JD, Granger HJ, Ledda F, Ziche M, 1998. Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinasel/2 activation in postcapillary endothelium. J Biol Chem 273: 4420-4426.
31. Pentinen RP, Kobayashi K, Bornstein P, 1988. Transforming growth factor β increased mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability. Proc Natl Acad Sci USA 85: 1105-1108.
32. Pertovaara L, Kaipainen A, Mustonen T, Orpana A, Ferrara N, Saksela O, Alitalo K, 1994. Vascular endothelial growth factor is induced in response to transforming growth factor-β in fibroblastic and epithelial cells. J Biol Chem 269: 6721-6274.
33. Richer C, Fornes P, Vacher E, Bruneval P, Giudicelli J-F, 1994. Trandolapril's protective effects in stroke-prone spontaneously hypertensive rat persists long after treatment withdrawal. Am J Cardiol 73: 26C-35C.
34. Sharma HS, Tang ZH, Gho BCG, Verdouw PD, 1995. Nucleotide sequence and expression of the porcine vascular endothelial growth factor. Biochem Biophys Acta 1260: 235-238.
35. Shweiki D, Itin A, Gitay-Goren H, Keshet E, 1993. Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis. J Clin Invest 91: 2235-2243.
36. Stier Jr CT, Chander P, Gutstein WH, Levine S, Itskovitz HD, 1991. Therapeutic benefit of captopril in salt-loaded stroke-prone spontaneously hypertensive rats is independent of hypotensive effect. Am J Hypertens 4: 680-687.
37. Torry RJ, Labarrere CA, Torry DS, Holt VJ, Faulk WP, 1995. Vascular endothelial growth factor expression in transplanted human hearts. Transplantation 60: 1451-1457.
38. Tsurumi Y, Murohara T, Krasinski K, Chen D, Witzenbichler B, Kearney M, Couffinthal T, Isner JM, 1997. Reciprocal relation between VEGF and NO in the regulation of endothelial integrity. Nat Med 3: 879-886.
39. Villarreal FJ, Dillmann WH, 1992. Cardiac hypertrophy-induced changes in mRNA levels for TGF-beta1, fibronectin, and collagen. Am J Physiol 262: H1861-H1866.
40. Wiemer G, Schölkens BA, Linz W, 1994. Endothelial protection by converting enzyme inhibitors. Cardiovasc Res 28: 166-172.
41. Wiemer G, Linz W, Schölkens BA, Wohlfart P, Malinski T, 1997a. Life-span extension of hypertensive rats by long-term inhibition correlates with increased nitric oxide availability. J Mol Cell Cardiol 29: A227.
42. Wiemer G, Linz W, Hatrik S, Schölkens BA, Malinski T, 1997b. Angiotensin-converting enzyme inhibition alters nitric oxide and superoxide release in normotensive and hypertensive rats. Hypertension 30: 1183-1190.