Angiotensin-converting enzyme inhibition alters nitric oxide and superoxide release in normotensive and hypertensive rats

Hypertension

Volumn 30, Issue 5, 1997, Pages 1183-1190

  Wiemer, Gabriele ^a   Linz, Wolfgang ^a   Hatrik, Stefan ^b   Schölkens, Bernward A ^a   Malinski, Tadeusz ^b  

^a SANOFI   (France)

^b OAKLAND UNIVERSITY   (United States)

Author keywords

Aging; Endothelium; Hypertension; Nitric oxide; Nitric oxide synthase III; Ramipril; Superoxide

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RAMIPRIL; SUPEROXIDE;

ADOLESCENT; AGING; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE THERAPY; ARTICLE; CONTROLLED STUDY; HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; VASCULAR ENDOTHELIUM;

EID: 0030689824     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.30.5.1183     Document Type: Article

References (32)

1. Luscher TF. The endothelium in hypertension: bystander, target or mediator. J Hypertens. 1994;12(suppl 10):S105-S116.
2. Luscher TF, Vanhoutte PM. Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Hypertension. 1986;8:344-348.
3. Dohi Y, Thiel MA, Buhler FR, Luscher TF. Activation of endothelial L-arginine pathway in resistance arteries. Hypertension. 1990; 15:170-179.
4. Tschudi MR, Mesaros S, Luscher TF, Malinski T. Direct in situ measurement of nitric oxide in mesenteric resistance arteries: increased decomposition by superoxide in hypertension. Hypertension, 1996;27:32-35.
5. Clozel M, Kuhn H, Hefti F. Effects of angiotensin converting enzyme inhibitors and of hydralazine on endothelial function in hypertensive rats. Hypertension, 1990;16:532-540.
6. Rubanyi GM, Kauser K, Graser T. Effect of cilazapril and indomethacin on endothelial dysfunction in the aortas of spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1993;22(suppl 5): S23-S30.
7. Kahonen M, Makynen H, Wu X, Arvola P, Porsti I. Endothelial function in spontaneously hypertensive rats: influence of quinapril treatment. Br J Pharmacol 1995;115:859-867.
8. Gohlke P, Lamberty V, Kuwer I, Bartenbach S, Schnell A, Linz W, Scholkens BA, Wiemer G, Unger T. Long-term low-dose angiotensin-converting enzyme inhibitor treatment increases vascular cyclic guanosine 3′,5′-monophosphate. Hypertension. 1993;22:682-687.
9. Becker RHA, Wiemer G, Linz W. Preservation of endothelial function by ramipril in rabbits on a long-term atherogenic diet. J Cardiovasc Pharmacol. 1991;18(suppl 2):S110-S115.
10. Wiemer G, Pierchala B, Mesaros S, Scholkens BA, Malinski T, Direct measurement of nitric oxide release from cultured endothelial cells stimulated by bradykinin or ramipril. Endothelium. 1996; 4:119-125.
11. The SOLVD Investigators. Effect of enalapril on mortality and development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med. 1992;327:685-691.
12. The AIRE Investigators. Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. Lancet. 1993;342:821-828.
13. The TRACE Investigators. A clinical trial of the angiotensin-converting enzyme inhibitor trandolapril in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 1995;333:1670-1676.
14. Wiemer G, Linz W, Scholkens BA, Wohlfart P, Malinski T. Life-span extension of hypertensive rats by long-term inhibition correlates with increased nitric oxide availability. J Mol Cell Cardiol. 1997;29:A227. Abstract.
15. Malinski T, Taha Z. Nitric oxide release from a single cell measured in situ by a porphyrinic-based microsensor. Nature. 1992;358: 676-678.
16. Malinski T, Czuchajowski L. Nitric oxide measurements by electrochemical methods. In: Feelisch M, Stamler JS, eds. Methods of Nitric Oxide Research. New York, NY: John Wiley & Sons, Inc; 1996:319-339.
17. Jia L, Furchgott RF. Inhibition by sulfhydryl compounds of vascular relaxation induced by nitric oxide and endothelium-derived relaxing factor. J Pharmacol Exp Ther. 1993;267:371-378.
18. Gyllenhammer H. Lucigenin chemiluminescence in the assessment of neutrophil superoxide production. J Immunol Methods. 1987;97: 209-213.
19. Pou S, Pou WS, Bredt DS, Snyder SH, Rosen GM. Generation of superoxide by purified brain nitric oxide synthase. J Biol Chem. 1992;267:24173-24176.
20. Kobayashi K, Miki M. A direct demonstration of reaction of nitric oxide with superoxide union by the use of pulse radiolysis. In: Asada K, Yoshikawa T, eds. Frontiers of Reactive Oxygen Species in Biology and Medicine. New York, NY: Elsevier Science Publishing Co; 1994:223-224.
21. Fridovich I. The biology of oxygen radicals. Science. 1978;201: 875-880.
22. Beckman JS, Chen J, Ischiropoulos H, Crow JP. Oxidative chemistry of peroxynitrite. In: Packer L, ed. Methods in Enzymology, Vol 233. San Diego, Calif: Academic Press Inc; 1994:229-240.
23. Greene B, Pacitti AJ, Souba WW. Characterization of L-arginine transport by pulmonary artery endothelial cells. Am J Physiol. 1993; 264:L351-L356.
24. Klatt P, Schmidt K, Uray G, Maver B. Multiple catalytic functions of brain nitric oxide synthase. J Biol Chem. 1994;268:14781-14787.
25. Bennet WS, Steitz TA. Glucose-induced conformational change in yeast hexokinase. Proc Natl Acad Sci U S A. 1978;75:4848-4852.
26. Luscher TF, Romero JC, Vanhoutte PM. Bioassay of endothelium-derived vasoactive substances in the aorta of normotensive and spontaneously hypertensive rats. J Hypertens. 1986;4(suppl 6):S81-S83.
27. Shirasaki Y, Kolm P, Nickols GA, Lee TJ-F. Endothelial regulation of cyclic GMP and vascular responses in hypertension. J Pharmacol Exp Ther. 1988;245:53-58.
28. Nava E, Luscher TF. Evidence for an increased production of nitric oxide in spontaneously hypertensive rats. Eur Clin Invest. 1994; 24(suppl 2):A45. Abstract.
29. Nava E, Noll G, Luscher TF. Increased activity of constitutive nitric oxide synthase in cardiac endothelium in spontaneous hypertension. Circulation. 1995;91:2310-2313.
30. Nakazono K, Watanabe N, Matsuno K, Sasaki J, Sato T, Inoue M. Does superoxide underlie the pathogenesis of hypertension? Proc Natl Acad Sci U S A. 1991;88:10045-10048.
31. Clancy RM, Leszczynska-Piziak J, Abramson SB, Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxsdase. J Clin Invest. 1992;90:1116-1121.
32. Wiemer G, Scholkens BA, Becker RHA, Busse R. Ramipril enhances endothelial autacoid formation by inhibiting breakdown of endothelium-derived bradykinin. Hypertension. 1991;18:558-563.