Th1 T cell responses to HIV-1 Gag protein delivered by a Listeria monocytogenes vaccine are similar to those induced by endogenous listerial antigens

Journal of Immunology

Volumn 163, Issue 3, 1999, Pages 1449-1456

  Mata, Marielena ^a   Paterson, Yvonne ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b 323 Johnson Pavilion ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; CD4 ANTIGEN; EPITOPE; GAG PROTEIN; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL VIRULENCE; CELLULAR IMMUNITY; CYTOTOXIC T LYMPHOCYTE; FEMALE; GENETIC ENGINEERING; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LISTERIA MONOCYTOGENES; LISTERIOSIS; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN TARGETING; VACCINATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL VACCINES; CYTOKINES; FEMALE; GENE PRODUCTS, GAG; HIV CORE PROTEIN P24; HIV-1; IMMUNOPHENOTYPING; LISTERIA MONOCYTOGENES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; TH1 CELLS; VACCINES, COMBINED;

EID: 0033178936     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (66)

1. Fauci, A. S. 1993. Multifactorial nature of human immunodeficiency virus disease:implications for therapy. Science 262:1011.
2. Hahn, B. H., G. M. Shaw, M. E. Taylor, R. R. Redfield, P. D. Markham, S. Z. Salahuddin, F. Wong-Stall, R. C. Gallo, E. S. Parks, and W. P. Parks. 1986. Genetic variation in HTLV-III/LAV over time in patients with AIDS or at risk for AIDS. Science 232:1548.
3. Saag, M., B. H. Hahn, J. Gibbons, Y. X. Li, E. S. Parks, W. P. Parks, and G. M. Shaw. 1988. Extensive variation of HIV type-1 in vivo. Nature 334:440.
4. Haigwood, N. L., and S. Zolla-Pazner. 1998. Humoral immunity to HIV, SIV, and SHIV. AIDS 12(Suppl. A):S121.
5. Kalams, S. A., and B. D. Walker. 1994. The cytotoxic T-lymphocyte response in HIV-1 infection. Clin. Lab. Med. 14:271.
6. Salk, A., P. A. Bretscher, P. L. Salk, M. Clerici, and G. Shearer. 1993. A strategy for prophylactic vaccination against HIV. Science 260:1270.
7. Clerici, M., and G. M. Shearer. 1993. A Th1→Th2 switch is a critical step in the etiology of HIV infection. Immunol. Today 14:107.
8. Falkow, S., R. R. Isberg, and D. A. Portnoy. 1992. The interaction of bacteria with mammalian cells. Annu. Rev. Cell Biol. 8:333.
9. + lymphocytes from mice infected with the intracellular bacterium Listeria monocytogenes. J. Immunol. 137:2688.
10. Bishop, D. K., and D. J. Hinrichs. 1987. Adoptive transfer of immunity to Listeria manocytogenes:the influence of in vitro stimulation on lymphocyte subset requirements. J. Immunol. 139:2005.
11. Weiskirch, L. M., and Y. Paterson. 1997. Listeria monocytogenes:a potent vaccine vector for neoplastic and infectious disease. Immunol. Rev. 158:159.
12. Jensen, E. R., H. Shen, F. O. Wettstein, R. Ahmed, and J. F. Miller. 1997. Recombinant Listeria monocytogenes as a live vaccine vehicle and a probe for studying cell-mediated immunity. Immunol. Rev. 158:147.
13. Schafer, R., D. A. Portnoy, S. A. Brassell, and Y. Paterson. 1992. Induction of a cellular immune response to a foreign antigen by a recombinant Listeria monocytogenes vaccine. J. Immunol. 149:53.
14. Ikonomidis, G., Y. Paterson, F. Kos, and D. Portnoy. 1994. Delivery of a viral antigen to the class I processing and presentation pathway by L. monocytogenes. J. Exp. Med. 180:2209.
15. + T cells in vivo:a study with the nucleoprotein of the lymphocytic choriomeningitis virus. Int. Immunol. 7:797.
16. Slifka, M. K., H. Shen, M. Matloubian, E. R. Jensen, J. F. Miller, and R. Ahmed. 1996. Antiviral cytotoxic T-cell memory by vaccination with recombinant Listeria monocytogenes. J. Virol. 70:2902.
17. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
18. + αβ-TCR transgenic T cells is macrophage dependent. Int. Immunol. 5:371.
19. Zhan, Y., and C. Cheers. 1998. Control of IL-12 and IFN-γ production in response to live or dead bacteria by TNF and other factors. J. Immunol. 161:1447.
20. Wagner, R. D., H. Steinberg, J. F. Brown, and C. J. Czuprynski. 1994. Recombinant interleukin-12 enhances resistance of mice to Listeria monocytogenes infection. Microb. Pathog. 17:175.
21. Tripp, C. S., M. K. Gately, J. Hakimi, P. Ling, and E. R. Unanue. 1994. Neutralization of IL-12 decreases resistance to Listeria in SCID and C. B-17 mice: reversal by IFN-γ. J. Immunol. 152:1883.
22. Dalton, D. K., S. Pitts-Meek, S. Keshav, I. S. Figari, A. Bradley, and T. A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 259:1739.
23. Huang, S., W. Hendriks, A. Althage, S. Hemmi, H. Bluethmann, R. Kamijo, J. Vilcek, R. M. Zinkernagel, and M. Aguet 1993. Immune responses in mice that lack the interferon-γ receptor. Science 259:1742.
24. Dai, W. J., G. Kohler, and F. Brombacher. 1997. Both innate and acquired immunity to Listeria monocytogenes infection are increased in IL-10-deficient mice. J. Immunol. 158:2259.
25. Haak-Frendscho, M., J. F. Brown, Y. Iizawa, R. D. Wagner, and C. J. Czuprynski. 1992. Administration of anti-IL-4 monoclonal antibody 11B11 increases the resistance of mice to Listeria monocytogenes infection. J. Immunol. 148:3978.
26. Frankel, F. R., S. Hegde, J. Lieberman, and Y. Paterson. 1995. Induction of cell-mediated immune responses to human immunodeficiency virus type 1 Gag protein by using Listeria monocytogenes as a live vaccine vector. J. Immunol. 155:4775.
27. d through interactions between a glutamine at P3 and pocket D. J. Immunol. 161: 2985.
28. Debouck, C., J. G. Gorniak, J. E. Strickler, T. D. Meek, B. W. Metcalf, and M. Rosenberg. 1987. Human immunodeficiency virus protease expressed in Escherichia coli exhibits autoprocessing and specific maturation of the gag precursor. Proc. Natl. Acad. Sci. USA 84:8903.
29. Julius, M. H., E. Simpson, and L. A. Herzenberg. 1973. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur. J. Immunol. 3:645.
30. Curry, R. C., P. A. Keiner, and G. L. Spitalny. 1987. A sensitive immunochemical assay for biologically active μIFN-γ. J. Immunol. Methods 104:137.
31. Mossman, T. R., and T. A. T. Fong. 1989. Specific assays for cytokine production by T cells. J. Immunol. Methods 116:151.
32. Chatelain, R., K. Varkila, and R. L. Coffman. 1992. IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 148:1182.
33. Karasuyama, H., and F. Melchers. 1988. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. Eur. J. Immunol. 18:97.
34. Brehm, K., J. Kreft, M. T. Ripio, and J. A. Vazquez-Boland. 1996. Regulation of virulence gene expression in pathogenic Listeria. Microbiologia 12:219.
35. Palker, T. J., T. J. Matthews, A. Langlois, M. E. Tanner, M. E. Martin, R. M. Scearce, J. E. Kim, J. A. Berzofsky, D. P. Bolognesi, and B. F. Haynes. 1989. Polyvalent human immunodeficiency virus synthetic immunogen comprised of envelope gp120 T helper cell sites and B cell neutralization epitopes. J. Immunol. 142:3612.
36. Shirai, M., C. D. Pendleton, and J. A. Berzofsky. 1992. Broad recognition of cytotoxic T cell epitopes from the HIV-1 envelope protein with multiple class I histocompatibility molecules. J. Immunol. 148:1657.
37. Berzofsky, J. A. 1988. Features of T-cell recognition and antigen structure useful in the design of vaccines to elicit T-cell immunity. Vaccine 6:89.
38. Alexander, J., J. Sidney, S. Southwood, J. Ruppert, C. Oseroff, A. Maewal, K. Snoke, H. M. Serra, R. T. Kubo, A. Sette, et al. 1994. Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides. Immunity 1:751.
39. Nakane, A., T. Minagawa, M. Kohanawa, Y. Chen, H. Sato, M. Moriyama, and N. Tsuruoka. 1989. Interactions between endogenous γ Interferon and tumor necrosis factor in host resistance against primary and secondary Listeria monocytogenes infections. Infect. Immun. 57:3331.
40. + T cell interactions in IFN-γ and IL-4 responses to viral infections:requirements for IL-2. J. Immunol. 160:5007.
41. Clerici, M., J. V. Giorgi, C. C. Chou, V. K. Gudeman, J. A. Zack, P. Gupta, H. N. Ho, P. G. Nishanian, J. A. Berzofsky, and G. M. Shearer. 1992. Cell-mediated immune response to human immunodeficiency virus (HIV) type 1 in seronegative homosexual men with recent sexual exposure to HIV-1. J. Infect. Dis. 165:1012.
42. Rowland-Jones, S. L., T. Dong, K. R. Fowke, J. Kimani, P. Krausa, H. Newell, T. Blanchard, K. Ariyoshi, J. Oyugi, E. Ngugi, et al. 1998. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. J. Clin. Invest. 102:1758.
43. + lymphocyte phenotype and cytokine production in long-term non-progressor and in progressor patients with HIV-1 infection. Clin. Exp. Immunol. 105:220.
44. Dyer, W. B., G. S. Ogg, M. A. Demoitie, X. Jin, A. F. Geczy, S. L. Rowland-Jones, A. J. McMichael, D. F. Nixon, and J. S. Sullivan. 1999. Strong human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte activity in Sydney Blood Bank Cohort patients infected with nef-defective HIV type 1. J. Virol. 73:436.
45. Clerici, M., D. R. Lucey, J. A. Berzofsky, L. A. Pinto, T. A. Wynn, S. P. Blatt, M. J. Dolan, C. W. Hendrix, S. F. Wolf, and G. Shearer. 1993. Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. Science 262:1721.
46. Salgame, P., M. X. Guan, A. Agahtehrani, and E. E. Henderson. 1998. Infection of T cell subsets by HIV-1 and the effects of interleukin-12. J. Interferon Cytokine Res. 18:521.
47. Chehimi, J., S. E. Starr, I. Frank, A. D'Andrea, X. Ma, R. R. MacGregor, J. Sennelier, and G. Trinchieri. 1994. Impaired interleukin 12 production in human immunodeficiency virus-infected patients. J. Exp. Med. 179:1361.
48. Taoufik, Y., O. Lantz, C. Wallon, A. Charles, E. Dussaix, and J. F. Delfraissy. 1997. Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes:an indirect interleukin-10-mediated effect. Blood 89:2842.
49. Cheers, C., I. F. C. McKenzie, H. Pavlov, C. Waid, and J. York. 1978. Resistance and susceptibility of mice to bacterial infection:course of listeriosis in resistant and susceptible mice. Infect. Immun. 19:763.
50. Cheers, C., and I. F. C. McKenzie. 1978. Resistance and susceptibility of mice to bacterial infection:genetics of listeriosis. Infect. Immun. 19:755.
51. Jones, D. E., M. M. Elloso, and P. Scott. 1998. Host susceptibility factors to cutaneous leishmaniasis. Front. Biosci. 3:D1171.
52. Pamer, E. G., A. J. A. M. Sijits, M. S. Villanueva, D. H. Busch, and S. Vijh. 1997. MHC class I antigen processing of Listeria monocytogenes proteins:implications for dominant and subdominant CTL responses. Immunol. Rev. 158:129.
53. Wagner, R. D., and C. J. Czuprynski. 1993. Cytokine mRNA expression in livers of mice infected with Listeria monocytogenes. J. Leukocyte Biol. 53:525.
54. Poston, R. M., and R. J. Kurlander. 1992. Cytokine expression in vivo during murine listeriosis:infection with live, virulent bacteria is required for monokine and lymphokine messenger RNA accumulation in the spleen. J. Immunol. 149: 3040.
55. Iizawa, Y., J. F. Brown, and C. J. Czuprynski. 1992. Early expression of cytokine mRNA in mice infected with Listeria monocytogenes. Infect. Immun. 60:4068.
56. Ehlers, S., M. E. Mielke, T. Blankenstein, and H. Hahn. 1992. Kinetic analysis of cytokine gene expression in the livers of naive and immune mice infected with Listeria monocytogenes:the immediate early phase in innate resistance and acquired immunity. J. Immunol. 149:3016.
57. Liu, Z., R. J. Simpson, and C. Cheers. 1994. Role of IL-6 in activation of T cells for acquired cellular resistance to Listeria monocytogenes. J. Immunol. 152:5375.
58. Hauser, T., K. Frei, R. M. Zinkernagel, and T. P. Leist. 1990. Role of tumor necrosis factor in Listeria resistance of nude mice. Med. Microbiol. Immunol. 179:95.
59. Rakhmilevich, A. L. 1995. Neutrophils are essential for resolution of primary and secondary infection with Listeria monocytogenes. J. Leukocyte Biol. 57:827.
60. Dai, W. J., W. Bartens, O. Kohler, M. Hufnagel, M. Kopf, and F. Brombacher. 1997. Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes-infected IFN-γ receptor-deficient mice. J. Immunol. 158:5297.
61. Mackaness, G. B. 1969. The influence of immunologically committed lymphoid cells on macrophage activity in vitro. J. Exp. Med. 129:973.
62. Samsom, J. N., A. Annema, P. H. Groeneveld, N. van Rooijen, J. A. Langermans, and R. van Furth. 1997. Elimination of resident macrophages from the livers and spleens of immune mice impairs acquired resistance against a secondary Listeria monocytogenes infection. Infect. Immun. 65:986.
63. + cells in resistance to primary and secondary infection, delayed-type hypersensitivity and adoptive transfer of resistance. Immunology 71:107.
64. Orme, I. M. 1989. Active and memory immunity to Listeria monocytogenes infection in mice is mediated by phenotypically distinct T-cell populations. Immunology 68:93.
65. North, R. J. 1973. Cellular mediators of anti-Listeria immunity as an enlarged population of short-lived replicating T cells:kinetics of their production. J. Exp. Med. 138:342.
66. Busch, D. H., I. Pilip, and E. G. Pamer. 1998. Evolution of a complex T cell receptor repertoire during primary and recall bacterial infection. J. Exp. Med. 188:61.