Direct androgenic regulation of calcitonin gene-related peptide expression in motoneurons of rats with mosaic androgen insensitivity

Journal of Neuroscience

Volumn 19, Issue 13, 1999, Pages 5597-5601

  Monks, Douglas A ^a   Vanston, Claire M ^a   Watson, Neil V ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

Author keywords

Androgen; Androgen receptor; Bulbocavernosus; Calcitonin gene related peptide; Cell autonomous; Levator ani; Mosaic; Penile reflexes; Sexual dimorphism; Spinal nucleus of the bulbocavernosus; tfm mutation

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE;

ANDROGEN INSENSITIVITY SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CORPUS CAVERNOSUM; GENE EXPRESSION REGULATION; HORMONAL REGULATION; IMMUNOREACTIVITY; LEVATOR ANI MUSCLE; MOTONEURON; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; RETROGRADE NERVE FIBER TRANSPORT; TARGET CELL; X CHROMOSOME INACTIVATION;

EID: 0033168324     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-13-05597.1999     Document Type: Article

References (33)

1. Blanco CE, Popper P, Micevych P (1997) α-CGRP mRNA levels in motoneurons innervating specific rat muscles. Mol Brain Res 44:253-261.
2. Breedlove SM, Arnold AP (1981) Sexually dimorphic motor nucleus in the rat lumbar spinal cord: response to adult hormone manipulation, absence in androgen-insensitive rats. Brain Res 225:297-307.
3. Christensen MD, Hulsebosch CE (1997) Spinal cord injury and antiNGF treatment results in changes in CGRP density and distribution in the dorsal horn in the rat. Exp Neurol 147:463-475.
4. Damassa DA, Smith ER, Tennent B, Davidson JM (1977) The relationship between circulating testosterone levels and male sexual behavior in rats. Horm Behav 8:275-286.
5. Dube JY, Lesage R, Tremblay RR (1975) Androgen and estrogen binding in rat skeletal and perineal muscles. Can J Biochem 54:50-55.
6. Ferguson GA, Takane Y (1989) Statistical analysis in psychology and education. Ed 6. New York: McGraw-Hill.
7. Forger NG, Hodges LL, Roberts SL, Breedlove SM (1992) Regulation of motoneuron death in the spinal nucleus of the bulbocavernosus. J Neurobiol 23:1192-1203.
8. Freeman LM, Padgett BA, Prins GS, Breedlove SM (1995) Distribution of androgen receptor immunoreactivity in the spinal cord of wild-type, androgen-insensitive and gonadectomized male rats. J Neurobiol 27:51-59.
9. Freeman LM, Watson NV, Breedlove SM (1996) Androgen spares androgen-insensitive motoneurons from apoptosis in the spinal nucleus of the bulbocavernosus in rats. Horm Behav 30:424-433.
10. Goldman AS, Shapiro BH, Neuman F (1976) Role of testosterone and its metabolites in the differentiation of the mammary gland in rats. Endocrinology 99:1490-1495.
11. Hart BL (1979) Activation of sexual reflexes by male rats by dihydrotestosterone but not estrogen. Physiol Behav 23:107-109.
12. Hodges-Savola CA, Fernandez HI (1995) A role for calcitonin-gene related peptide in the regulation of rat skeletal muscle G4 acetylcholinesterase. Neurosci Lett 190:117-120.
13. Jordan CL, Pawson PA, Arnold AP, Grinnel AD (1992) Hormonal regulation of motor unit size and synaptic strength during synapse elimination in the rat levator ani muscle. J Neurosci 12:4447-4459.
14. Jordan CL, Padgett B, Hershey J, Prins G, Arnold A (1997) Ontogeny of androgen receptor immunoreactivity in lumbar motoneurons and in the sexually dimorphic levator ani muscle of male rats. J Comp Neurol 379:88-98.
15. Kedzierski W, Bok D, Travis GH (1998) Non-cell-autonomous photoreceptor degeneration in rds mutant mice mosaic for expression of a rescue transgene. J Neurosci 18:4076-4082.
16. Kemppainen JA, Lane MV, Sar M, Wilson EM (1992) Androgen receptor phosphorylation, turnover, nuclear transport and transcriptional activation. J Biol Chem 267:968-974.
17. Lu B, Fu W-M, Greengard P, Poo M-M (1993) Calcitonin gene related peptide potentiates synaptic responses at developing neuromuscular junction. Nature 363:76-79.
18. Lyon MF (1961) Gene action in the X chromosome of the mouse (Mus musculus L). Nature 190:372-373.
19. Monk M, Harper MI (1979) Sequential X chromosome inactivation coupled with cellular differentiation in early mouse embryos. Nature 281:311-313.
20. Nelson RJ (1997) The use of genetic "knockout" mice in behavioral endocrinology research. Horm Behav 31:188-196.
21. New HV, Mudge AW (1986) Calcitonin gene-related peptide regulates muscle acetylcholine receptor synthesis. Nature 323:809-811.
22. Piehl F, Cullheim S, Hokfelt T, Hammarberg H (1998) Regulatory effects of trophic factors on expression and distribution of CGRP and GAP-43 in rat motoneurons. J Neurosci Res 51:1-14.
23. Popper P, Micevych PE (1989) The effect of castration on calcitonin gene-related peptide in spinal motor neurons. Neuroendocrinology 50:338-343.
24. Popper P, Micevych PE (1990) Steroid regulation of calcitonin gene-related peptide mRNA expression in motoneurons of the spinal nucleus of the bulbocavernosus. Mol Brain Res 8:159-166.
25. Popper P, Abelson L, Micevych PE (1992a) Differential regulation of α-calcitonin gene-related peptide and preprocholcystokinin messenger RNA expression in a motoneurons. Neuroscience 51:87-96.
26. Popper P, Ulbarri C, Micevych PE (1992b) Muscle activity regulates the expression of calcitonin gene-related peptide in motoneurons of the spinal nucleus of the bulbocavernosus. Mol Brain Res 13:43-51.
27. Tanaka J, Arnold AP (1993) Androgenic modulation of the activity of lumbar motoneurons involved in the rat bulbocavernosus reflex. Exp Brain Res 94:301-307.
28. Tsujimoto T, Kuno M (1988) Calcitonin gene-related peptide prevents disuse-induced sprouting of rat motor nerve terminals. J Neurosci 8:3951-3957.
29. Vrbova G, Gordon T, Jones R (1994) Nerve-muscle interaction. New York: Chapman & Hall.
30. Ward OB, Ward IL, Eckert MA, Carlucci JR, Wexler AM (1996) Critical periods of sensitivity of sexually dimorphic spinal nuclei to prenatal testosterone exposure in female rats. Horm Behav 30:407-415.
31. Watson NV, Freeman LM, Breedlove SM (1996) Neuronal size in the spinal nucleus of the bulbocavernosus: direct modulation by androgen in animals with mosaic genetic androgen insensitivity. Soc Neurosci Abstr 26:697.
32. Watson RE, Weigand SJ, Clough RW, Hoffman GE (1986) Use of cryoprotectant to maintain long-term peplide immunoreactivity and tissue morphology. Peptides 7:155-159.
33. Xu J, Forger NG (1998) Expression and androgen regulation of the ciliary neurotrophic factor receptor (CNTFRα) in muscles and spinal cord. J Neurobiol 35:217-225.