Longitudinal versus radial effects of hydroxypropylmethylcellulose on gastrointestinal glucose absorption in dogs

European Journal of Pharmaceutical Sciences

Volumn 8, Issue 3, 1999, Pages 211-219

  Reppas, Christos ^a   Greenwood, Dale E ^b   Dressman, Jennifer B ^c,d  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF ATHENS   (Greece)

^c ELI LILLY AND COMPANY   (United States)

^d UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Gastrointestinal transit; Glucose; HPMC; Luminal osmolality; Luminal viscosity; Soluble fibers; Water flux

Indexed keywords

GLUCOSE; HYDROXYPROPYLMETHYLCELLULOSE;

ANIMAL EXPERIMENT; ARTICLE; DOG; DUODENUM FISTULA; FEMALE; GASTROINTESTINAL ABSORPTION; GASTROINTESTINAL TRANSIT; GLUCOSE ABSORPTION; INTESTINE TRANSIT TIME; NONHUMAN; OSMOLALITY; PRIORITY JOURNAL; VISCOSITY; WATER TRANSPORT;

ANIMALS; BLOOD GLUCOSE; DIETARY FIBER; DOGS; FEMALE; GASTROINTESTINAL TRANSIT; GLUCOSE; INTESTINAL ABSORPTION; METHYLCELLULOSE; OSMOLAR CONCENTRATION; SOLUTIONS; VISCOSITY;

EID: 0033166406     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(99)00009-3     Document Type: Article

References (28)

1. Birkner H.J., Kern F. In vitro adsorption of bile acids to food residues, salicylazosulfapyridine and hemicellulose. Gastroenterology. 67:1974;237-244.
2. Blackburn N.A., Johnson I.T. The effect of guar gum on the viscosity of the gastrointestinal contents and on glucose uptake from the perfused jejunum in the rat. Br. J. Nutr. 46:1981;239-246.
3. Blackburn N.A., Redfern J.S., Jarjis H., Holgate A.M., Hanning I., Scarpello J.H.B., Johnson I.T., Read N.W. The mechanism of action of guar gum in improving glucose tolerance in man. Clin. Sci. 66:1984;329-336.
4. Borchard G., Luessen H.L., Kolter K., Schehlmann V., Sanner A., Verhoef J.C., De Boer A.G., Junginger H.E. Acrylic/maleinic co-polymers and derivatives for transmucosal drug delivery. Proc. 2nd World Meeting APGI/APV, Paris, 25-28 May :1998.
5. Brener W., Hendrix T.R., McHugh P.R. Regulation of the gastric emptying of glucose. Gastroenterology. 85:1983;76-82.
6. Bueno L., Praddaude F., Fioramonti J., Ruckebusch Y. Effect of dietary fiber on gastrointestinal motility and jejunal transit time in dogs. Gastroenterology. 80:1981;701-707.
7. Ellis P.R., Roberts F.G., Low A.G., Morgan L.M. The effect of high-molecular-weight guar gum on net apparent glucose absorption and net apparent insulin and gastric inhibitory polypeptide production in the growing pig: relationship to rheological changes in jejunal digesta. Br. J. Nutr. 74:1995;539-556.
8. Ellsenhans B., Sufke U., Blume R., Caspary W.F. The influence of carbohydrate gelling agents on rat intestinal transport of monosaccharides and neural amino acids in vitro. Clin. Sci. 59:1980;373-380.
9. Flourie B., Vidon N., Florent C., Bernier J.J. Effect of pectin on jejunal glucose absorption in man. Gut. 23:1982;A911.
10. Forman L.P., Schneeman B.O. Dietary pectin's effect on starch utilization in rats. J. Nutr. 112:1982;528-533.
11. Gao P., Fagerness P.E. Diffusion in HPMC gels. I Determination of drug and water diffusivity by pulsed-field gradient spin-echo NMR. Pharm. Res. 12:1995;955-964.
12. Glantz S.A., Primer of Biostatistics. 1981;200 McGraw Hill Co, New York.
13. Holt S., Heading R.C., Carter D.C., Prescott L.F., Tothill P. Effect of gel fibre on gastric emptying and absorption of glucose and paracetamol. Lancet. 1:1979;636-639.
14. Jenkins D.J.A., Wolever T.M.S., Leeds A.R., Gassull M.A., Haisman P., Dilawari J., Goff D.V., Metz G.L., Alberti K.G.M.M. Dietary fiber, fiber analogues and glucose tolerance: Importance of viscosity. Br. Med. J. 1:1978;1392-1394.
15. Johnson I.T., Gee I.M. Effect of gel-forming gums on the intestinal unstirred layer and sugar transport in vitro. Gut. 22:1981;398-403.
16. Lin H.C., Doty J.E., Reedy T.J., Meyer J.H. Inhibition of gastric emptying by glucose depends on length of intestine exposed to nutrient. Am. J. Physiol. 256:1989;G404-G411.
17. Meddings J.B., Westergaard H. Intestinal glucose transport using perfused rat jejunum in vivo: model analysis and derivation of corrected kinetic constants. Clin. Sci. 76:1989;403-413.
18. Meyer J.H., Dressman J.B., Fink A., Amidon G.L. Effect of size and density on canine gastric emptying of non digestible solids. Gastroenterology. 89:1985;805-813.
19. Meyer J.H., Gu Y.G., Jehm D., Taylor I.L. Intragastric vs. intraintestinal viscous polymers and glucose tolerance after liquid meals of glucose. Am. J. Clin. Nutr. 48:1988;260-266.
20. Pilsch S.M., Physiological Effects and Health Consequences of Dietary Fiber. 1987;91 Life Science Research Office, FASEB, Bethesda, MD.
21. Reppas C., Meyer J.H., Sirois P.J., Dressman J.B. Effect of hydroxypropylmethylcellulose on gastrointestinal transit and luminal viscosity in dogs. Gastroenterology. 100:1991;1217-1223.
22. Reppas C., Dressman J.B. Viscosity modulates blood glucose response to nutrient solutions in dogs. Diabetes Res. Clin. Pract. 17:1992;81-88.
23. Reppas C., Adair C.H., Barnett J.L., Berardi R.R., Duross D., Swidan S.Z., Thill P.F., Tobey S.W., Dressman J.B. High viscosity HPMC reduces postprandial blood glucose concentration in NIDDM patients. Diabetes Res. Clin. Pract. 22:1993;61-69.
24. Reppas C., Eleftheriou G., Greenwood D.E., Symillides M., Macheras P., Dressman J.B. The Effect of HPMC - a cholesterol lowering agent - on oral drug absorption in dogs. Biopharm. Drug. Dispos. 19:1998;523-530.
25. Wallwork S.C., Grant D.J.W., Physical Chemistry. 3rd ed :1977;478 Longman, NY, New York.
26. Wolever T.M.S., Jenkins D.J.A., Nineham R., Alberti K.G.M.M. Guar gum and reduction of postprandial glycemia: Effect of incorporation into solid food, liquid food, and both. Br. J. Nutr. 41:1979;505-510.
27. Wursch P., Pi-Sunyer F.X. The role of viscous soluble fiber in the metabolic control of diabetes. A review with special emphasis on cereals rich in beta-glucan. Diabetes Care. 20:1997;1774-1780.
28. Yamada, T., Alpers, D.H., Owyang, C., Powell, D.W., Silverstein, F.E. (Eds.), 1991. Textbook of Gastroenterology, Vol. 1, J.B. Lippincott Co, Philadelphia, p. 147 and 254.