Attenuation by phenylbutazone of the renal effects and excretion of frusemide in horses

Equine Veterinary Journal

Volumn 31, Issue 4, 1999, Pages 289-295

  Dyke, T M ^a   Hinchcliff, K W ^a   Sams, R A ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Frusemide; Horse; Phenylbutazone; Renal

Indexed keywords

EQUIDAE; EQUUS CABALLUS;

DIURETIC AGENT; ELECTROLYTE; FUROSEMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PHENYLBUTAZONE;

ANIMAL; ANIMAL DISEASE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORSE; KIDNEY; PHYSIOLOGY; PREMEDICATION; RANDOMIZED CONTROLLED TRIAL; URINE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; DIURETICS; ELECTROLYTES; FEMALE; FUROSEMIDE; HORSES; KIDNEY; PHENYLBUTAZONE; PREMEDICATION;

EID: 0033158876     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-3306.1999.tb03819.x     Document Type: Article

References (25)

1. Boles-Ponto, L.L. and Schoenwald, R.D. (1990) Frusemide (frusemide) A pharmacokinetic/pharmacodynamic review (Part I). Clin. Pharmacokinet. 18, 381-408.
2. Breyer, J. and Jacobson, H.R. (1990) Molecular mechanisms of diuretic agents. Ann. Rev. Med. 41, 265-275.
3. Chay, S., Woods, W.E., Rowse, K., Nugent, T.E., Blake, J.W. and Tobin, T. (1983) The pharmacology of frusemide in the horse. V. Pharmacokinetics and blood levels of frusemide after intravenous administration. Drug Metab. Dispos. 11, 226-231.
4. Chennavasin, P., Seiwell, R. and Brater, D.C. (1980) Pharmacokinetic-dynamic analysis of the indomethacin-frusemide interaction in man. J. Pharmacol. Exp. Ther. 215, 77-81.
5. Data, J.L., Rane, A., Gerkens, J., Wilkinson, G.R., Nies, A.S. and Branch, R.A. (1978) The influence of indomethacin on the pharmacokinetics, diuretic response and hemodynamics of frusemide in the dog. J. Pharmacol. Exp. Therap. 206, 431-438
6. Dyke, T.M., Hinchcliff, K.W., Sams, R.A., Muir, W.W. and McKeever K.H. (1996) The effects of submaximal exercise on the pharmacokinetics of frusemide in horses. J. vet. Pharmacol. Therap. 19, 164-166.
7. Dyke, T.M., Hubbell, J.A.E., Grosenbaugh, D.A., Beard, W., Mitten, L., Sams, R.A. and Hinchcliff, K.W. (1998) The pharmacokinetics of frusemide in anesthetized horses after bilateral ureteral ligation. J. vet. Pharmacol. Therap. 21, 298.
8. Gross, D.K., Hinchcliff, K.W. and Morley, P.S. (1997) Furosemide use in racing Thoroughbreds in North America (abstract). Proc. Conf. Res. Workers Anim. Dis. 78, 50.
9. Hammarlund-Udenaes, M. and Benet, L.Z. (1989) Furosemide pharmacokinetics and pharmacodynamics in health and disease - an update. J. Pharmacokinet. Biopharm. 17, 1-46.
10. Hinchcliff, K.W., McKeever, K.H. and Muir, W.W. (1991) Furosemide-induced changes in plasma and blood volume in horses. J. vet. Pharmacol. Therap. 14, 411-417.
11. Hinchcliff, K.W., McKeever, K.H., Muir, W.W. and Sams, R.A. (1995) Pharmacologic interaction of furosemide and phenylbutazone in horses. Am. J. vet. Res. 56, 1206-1212.
12. Hinchcliff, K.W., Hubbell, J.A.E., Grosenbaugh, D., Mitten, L.A. and Beard, W.L. (1996) Hemodynamic effects of furosemide are dependent on diuresis. Proc. Ann. Conv. Am. Assoc. Equine Pract. 42, 229-230.
13. Hinchcliff, K.W. and McKeever, K.H. (1998) Fluid administration attenuates the haemodynamic effect of frusemide in running horses. Equine vet. J. 30, 246-250.
14. Kirchner, K.A. (1985) Prostaglandin inhibitors alter loop segment chloride uptake during frusemide diuresis. Am. J. Physiol. 248, F698-F704.
15. Kirchner, K.A. (1988) Role of antidiuretic hormone in the attenuated frusemide response observed during indomethacin administration. J. Lab. Clin. Med. 111, 237-243.
16. Kurosawa, M., Ohtake, I., Tsuji, T. and Murakami, M. (1991) The diuretic effect and fate of frusemide in horses. Jap. J. equine Sci. 2, 49-57.
17. Mitten, L. and Hinchcliff, K.W. (1997) Non-steroidal anti-inflammatory drugs. In: Current Therapy in Equine Medicine 4, W.B. Saunders Co., Philadelphia. p 724.
18. Muir, W.W., Milne, D.W. and Skarda, R.T. (1976) Acute hemodynamic effects of frusemide administered intravenously in the horse. Am. J. vet. Res. 37, 1177-1180.
19. Nies, A., Gal, J., Fadul, S. and Gerber, J. (1983) Indomethacin-frusemide interaction: the importance of renal blood flow. J. Pharmacol. Exp. Ther. 226, 27-32.
20. Olsen, S.C., Coyne, C.P. and Lowe, B.S. (1992) Influenceof frusemide on hemodynamic responses during exercise in horses. Am. J. vet. Res. 53, 742-747.
21. Rivas, L.J. and Hinchcliff, K.W. (1997) Effect of frusemide and subsequent intravenous fluid administration on right atrial pressure of splenectomized horses. Am. J. vet. Res. 58, 632-635.
22. Roberts, L.B., Blake, J. W. and Tobin, T. (1978) The pharmacology of frusemide in the horse. II. Its detection, pharmacokinetics and clearance from urine. J. equine med. Surg. 2, 185-194.
23. Rubie, S., Robinson, N.B., Stoll, M., Broadstone, R.V. and Derksen, F.J. (1993) Flunixin meglumine blocks frusemide-induced bronchodilation in horses with chronic obstructive pulmonary disease. Equine vet. J. 25, 138-142.
24. Schott, H.C., Hines, M.T. and Bayly, W.M. (1993) Phenylbutazone inhibition of frusemide diuresis in horses (abstract). J. vet. intern. Med. 7, 150.
25. Uboh, C.E., Soma, L.R., Rudy, J.A., Morgan, E., Mengeringhausen, K. and Sams, R. (1992) Plasma concentration of frusemide versus specific gravity of urine in predicting dose of administration in racehorses. Res. Commun. Chem. Pathol. Pharmacol. 77, 201-218.