C-CAM-mediated adhesion leads to an outside-in dephosphorylation signal

European Journal of Biochemistry

Volumn 262, Issue 2, 1999, Pages 541-546

  Lucka, Lothar ^a   Budt, Matthias ^b   Cichocka, Iwona ^b   Danker, Kerstin ^b   Horstkorte, Rüdiger ^b   Reutter, Werner ^b  

^a Inst fur Molekularbiologie/B   (Germany)

^b NONE

Author keywords

Antibody clustering; Carcinoembryonic antigen; Cell cell adhesion; Phosphorylation; Signal transduction

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CELL ADHESION MOLECULE; PROTEIN C CAM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL AGGREGATION; DEPHOSPHORYLATION; IMMUNOFLUORESCENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD; BLOTTING, WESTERN; CELL ADHESION; CELL ADHESION MOLECULES; CELL MEMBRANE; CHO CELLS; CRICETINAE; FLUORESCENT ANTIBODY TECHNIQUE; GLYCOPROTEINS; PHOSPHORYLATION; PRECIPITIN TESTS; RATS; SIGNAL TRANSDUCTION;

EID: 0033153421     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00402.x     Document Type: Article

References (34)

1. 1. Thomas, P., Toth, C.A., Saini, K.S., Jessup, J.M. & Steele, G. Jr (1990) The structure, metabolism and function of the carcinoembryonic antigen gene family. Biochim. Biophys. Acta 1032, 177-189.
2. 2. Thompson, J.A., Grunert, F. & Zimmermann, W. (1991) The carcinoembryonic antigen gene family: molecular biology and clinical perspectives. J. Clin. Lab. Anal. 5, 344-366.
3. 3. Thompson, J. A. (1995) Molecular cloning and expression of carcinoembryonic antigen gene family members. Tumour Biol. 16, 10-16.
4. 4. Obrink, B. (1997) CEA adhesion molecules: multifunctional proteins with signal-regulatory properties. Curr. Opin. Cell Biol. 9, 616-626.
5. 5. Culic, O., Huang. Q.H., Flanagan, D., Hixson, D. & Lin, S.H. (1992) Molecular cloning and expression of a new rat liver cell-CAM105 isoform. Differential phosphorylation of isoforms. Biochem. J. 285, 47-53.
6. 6. Cheung, P.H., Luo, W., Qiu, Y., Zhang, X., Earley, K., Millirons, P. & Lin, S.H. (1993) Structure and function of C-CAM1. The first immunoglobulin domain is required for intercellular adhesion. J. Biol. Chem 268, 24303-24310.
7. 7. Olsson, H., Wikstrom, K., Kjellstrom, G. & Obrink, B. (1995) Cell adhesion activity of the short cytoplasmic domain isoform of C-CAM (C-CAM2) in CHO cells. FEBS Lett. 365, 51-56.
8. 8. Lucka, L., Cichocka, I., Bäumler, K., Bechler, K. & Reutter, W. (1995) A short isoform of carcinoembryonic-antigen-related rat liver cell-cell adhesion molecule (C-CAM/gpl 10) mediates intercellular adhesion. Sequencing and recombinant functional analysis. Eur J. Biochem. 234, 527-535.
9. 9. Odin, P., Tingstrom, A. & Obrink, B. (1986) Chemical characterization of cell-CAM 105, a cell-adhesion molecule isolated from rat liver membranes. Biochem. J. 236, 559-568.
10. 10. Becker, A., Neumeier, R., Park, C.S., Gossrau, R. & Reutter, W. (1986) Identification of a transformation-sensitive 110-kDa plasma membrane glycoprotein of rat hepatocytes. Eur J. Cell Biol. 39, 417-423.
11. 11. Becker, A., Gossrau, R., Hoffmann, C. & Rentier, W. (1989) Localization of a putative cell adhesion molecule (gpl 10) in Wistar and Fischer rat tissues. Histochemistry 93, 55-61.
12. 12. Hsieh, J.T., Luo, W., Song, W., Wang, Y., Kleinerman, D.I., Van, N.T. & Lin, S.H. (1995) Tumor suppressive role of an androgen-regulated epithelial cell adhesion molecule (C-CAM) in prostate carcinoma cell revealed by sense and antisense approaches. Cancer Res. 55, 190-197.
13. 13. Kleinerman, D.I., Dinney, C.P., Zhang, W.W., Lin, S.H., Van, N.T. & Hsieh, J.T. (1996) Suppression of human bladder cancer growth by increased expression of C-CAM1 gene in an orthotopic model. Cancer Res. 56, 3431-3435.
14. 14. Luo, W., Wood, C.G., Earley, K., Hung, M.C. & Lin, S.H. (1997) Suppression of tumorigenicity of breast cancer cells by an epithelial cell adhesion molecule (C-CAM1): the adhesion and growth suppression are mediated by different domains. Oncogene 14, 1697-1704.
15. 15. Turbide, C., Kunath, T., Daniels, E. & Beauchemin, N. (1997) Optimal ratios of biliary glycoprotein isoforms required for inhibition of colonic tumor cell growth. Cancer Res. 57, 2781-2788.
16. 16. Leusch, H.G., Drzeniek, Z., Hefta, S.A., Markos-Pusztai, Z. & Wagener, C. (1991) The putative role of members of the CEA-gene family (CEA, NCA an BGP) as ligands for the bacterial colonization of different human epithelial tissues. Zentralbl Bakteriol. 275, 118-122.
17. 17. Gray-Owen, S.D., Dehio, C., Haude, A., Grunert, F. & Meyer, T.F. (1997) CD66 carcinoembryonic antigens mediate interactions between Opa-expressing Neisseria gonorrhoeae and human polymorphonuclear phagocytes. EMBO J. 16, 3435-3445.
18. 18. Williams, R.K., Jiang, G.S. & Holmes, K.V. (1991) Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins. Proc. Natl Acad. Sci. USA 88, 5533-5536.
19. 19. Dveksler, G.S., Pensiero, M.N., Dieffenbach, C.W., Cardellichio, C.B., Basile, A.A., Elia, P.E. & Holmes, K.V. (1993) Mouse hepatitis virus strain A59 and blocking antireceptor monoclonal antibody bind to the N-terminal domain of cellular receptor. Proc. Natl Acad. Sci. USA 90, 1716-1720.
20. 20. Klein, M.L., McGhee, S.A., Baranian, J., Stevens, L. & Hefta, S.A. (1996) Role of nonspecific cross-reacting antigen, a CD66 cluster antigen, in activation of human granulocytes. Infect. Immun. 64, 4574-4579.
21. 21. Stocks, S.C., Ruchaud-Sparagano, M.H., Kerr, M.A., Grunert, F., Haslett, C. & Dransfield, I. (1996) CD66: role in the regulation of neutrophil effector function. Eur J. Immunol. 26, 2924-2932.
22. 22. Hunter, I., Lindh, M. & Obrink, B. (1994) Differential regulation of C-CAM isoforms in epithelial cells. J Cell Sci. 107, 1205-1216.
23. 23. Brummer, J., Neumaier, M., Gopfert, C. & Wagener, C. (1995) Association of pp. 60c-src with biliary glycoprotein (CD66a), an adhesion molecule of the carcinoembryonic antigen family down-regulated in colorectal carcinomas. Oncogene 11, 1649-1655.
24. 24. Beauchemin, N., Kunath, T., Robitaille, J., Chow, B., Turbide, C., Daniels, E. & Veillette, A. (1997) Association of biliary glycoprotein with protein tyrosine phosphatase SHP-1 in malignant colon epithelial cells. Oncogene 14, 783-790.
25. 25. Müller, M., Ishikawa, T., Berger, U., Klunemann, C., Lucka, L., Schreyer, A., Kannicht, C., Reutter, W., Kurz, G. & Keppler, D. (1991) ATP-dependent transport of taurocholate across the hepatocyte canalicular membrane mediated by a 110-kDa glycoprotein binding ATP and bile salt. J. Biol. Chem 266, 18920-18926.
26. 26. Sippel, C.J., Suchy, F.J., Ananthanarayanan, M. & Perlmutter, D.H. (1993) The rat liver ecto-ATPase is also a canalicular bile acid transport protein, J. Biol. Chem 268, 2083-2091.
27. 27. Lin, S.H. & Guidotti, G. (1989) Cloning and expression of a cDNA coding for a rat liver plasma membrane ecto-ATPase. The primary structure of the ecto-ATPase is similar to that of the human biliary glycoprotein I. J. Biol. Chem 264, 14408-14414.
28. 28. Cheung, P.H., Culic, O., Qiu, Y., Earley, K., Thompson, N., Hixson, D.C. & Lin, S.H. (1993) The cytoplasmic domain of C-CAM is required for C-CAM-mediated adhesion function: studies of a C-CAM transcript containing an unspliced intron. Biochem. J. 295, 427-435.
29. 29. Edlund, M., Wikstrom, K., Toomik, R., Ek, P. & Obrink, B. (1998) Characterization of protein kinase C-mediated phosphorylation of the short cytoplasmic domain isoform of C-CAM. FEBS Lett. 425, 166-170.
30. 30. Najjar, S.M., Philippe, N., Suzuki, Y., Ignacio, G.A., Formisano, P., Accili, D. & Taylor, S.I. (1995) Insulin-stimulated phosphorylation of recombinant pp. 120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase. Biochemistry 34, 9341-9349.
31. 31. Huber, M., Izzi, L., Grondin, P., Houde, C., Kunath, T., Veillette, A. & Beauchemin, N. (1999) The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells. J. Biol. Chem 274, 335-344.
32. 32. Becker, A., Lucka, L., Kilian, C., Kannicht, C. & Reutter, W. (1993) Characterisation of the ATP-dependent taurocholate-carrier protein (gpl 10) of the hepatocyte canalicular membrane. Eur J. Biochem. 214, 539-548.
33. 33. Lin, S.H., Luo, W., Earley, K., Cheung, P. & Hixson, D.C. (1995) Structure and function of C-CAM1: effects of the cytoplasmic domain on cell aggregation. Biochem. J. 311, 239-245.
34. 34. Hunter, I., Sawa, H., Edlund, M. & Obrink, B. (1996) Evidence for regulated dimerization of cell-cell adhesion molecule (C-CAM) in epithelial cells. Biochem. J. 320, 847-853.