Selected classes of minimised hammerhead ribozyme have very high cleavage rates at low Mg2+ concentration

Nucleic Acids Research

Volumn 27, Issue 11, 1999, Pages 2400-2407

  Conaty, Jason ^a,b   Hendry, Philip ^a   Lockett, Trevor ^a  

^a CSIRO   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

MAGNESIUM ION; PHOSPHODIESTERASE; RIBOZYME;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION;

ANIMALS; DIMERIZATION; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; HUMANS; INTERLEUKIN-2; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MAGNESIUM; NUCLEIC ACID CONFORMATION; REPRESSOR PROTEINS; RNA, CATALYTIC; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 0033151843     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/27.11.2400     Document Type: Article

References (27)

1. Williams,K.P. and Bartel,D.P. (1996) In Eckstein,F. and Lilley,D.M.J. (eds), Catalytic RNA. Springer-Verlag, Berlin, Germany.
2. Symons,R.H. (1992) Annu. Rev. Biochem., 61, 641-671.
3. Uhlenbeck,O.C. (1987) Nature, 328, 596-600.
4. Haseloff,J. and Gerlach,W.L. (1988) Nature, 334, 585-591.
5. Perriman,R., Delves,A. and Gerlach,W.L. (1992) Gene, 113, 157-163.
6. Shimayama,T., Nishikawa,S. and Taira,K. (1995) Biochemistry, 34, 3649-3654.
7. Zoumadakis,M. and Tabler,M. (1995) Nucleic Acids Res., 23, 1192-1196.
8. McCall,M.J., Hendry,P. and Jennings,P.A. (1992) Proc. Natl Acad. Sci. USA, 89, 5710-5741.
9. Hendry,P., Moghaddam,M.J., McCall,M.J., Jennings,P.A., Ebel,S. and Brown,T. (1994) Biochim. Biophys. Acta, 1219, 405-412.
10. Hendry,P. and McCall,M. (1995) Nucleic Acids Res., 23, 3922-3927.
11. Tuschl,T. and Eckstein,F. (1993) Proc. Natl Acad. Sci. USA, 90, 6991-6994.
12. Long,D.M. and Uhlenbeck,O.C. (1994) Proc. Natl Acad. Sci. USA, 91, 6977-6981.
13. Pley,H.W., Flaherty,K.M. and McKay,D.B. (1994) Nature, 372, 68-74.
14. Scott,W.G., Finch,J.T. and Klug,A. (1995) Cell, 81, 991-1002.
15. Hendry,P. and McCall,M. (1996) Nucleic Acids Res., 24, 2679-2684.
16. McCall,M.J., Hendry,P. and Lockett,T.J. (1997) In Turner,P.C. (ed.), Ribozyme Protocols. Humana Press, Totowa, NJ, Vol. 74, pp. 151-159.
17. Flatman,P.W. (1991) Annu. Rev. Physiol., 53, 259-271.
18. Freier,S.M., Kierzek,R., Jaeger,J.A., Sugimoto,N., Caruthers,M.H., Neilson,T. and Turner,D.H. (1986) Proc. Natl Acad. Sci. USA, 83, 9373-9377.
19. Amontov,S.V. and Taira,K. (1996) J. Am. Chem. Soc., 118, 1624-1628.
20. Kuwabara,T., Warashina,M., Orita,M., Koseki,S., Ohkawa,J. and Taira,K. (1998) Nature Biotechnol., 16, 961-965.
21. Ishizaka,M., Ohsima,Y. and Tani,T. (1995) Biochem. Biophys. Res. Commun., 214, 403-409.
22. Thomson,J.B., Sigurdsson,S.T., Zeuch,A. and Eckstein,F. (1996) Nucleic Acids Res., 24, 4401-4406.
23. Forster,A.C. and Symons,R.H. (1987) Cell, 49, 211-220.
24. Heus,H.A. and Pardi,A. (1991) Science, 253, 191-194.
25. Butcher,S.E., Dieckmann,T. and Feigon,J. (1997) J. Mol. Biol., 268, 348-358.
26. Zillmann,M., Limauro,S.E. and Goodchild,J. (1997) RNA, 3, 734-747.
27. Hendry,P., Lockett,T.J. and McCall,M.J. (1998) In Scanlon,K.J. (ed.), Methods in Molecular Medicine. Humana Press, Totowa, NJ, Vol. 11, pp. 1-15.