Relationship between the kinetics of micronuclei induction and the mechanism of chromosome break formation by methylnitrosourea in mice in vivo

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 427, Issue 1, 1999, Pages 31-38

  Morales Ramirez P ^a   Vallarino Kelly, T ^a  

^a INSTITUTO NACIONAL DE INVESTIGACIONES NUCLEARES   (Mexico)

Author keywords

Chromosome break formation; Methylnitrosourea; Micronuclei induction

Indexed keywords

METHYLNITROSOUREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL KINETICS; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; CONTROLLED STUDY; CYTOTOXICITY; DNA REPAIR; ERYTHROCYTE; GENOTOXICITY; LATENT PERIOD; MALE; MICRONUCLEUS; MOUSE; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CHROMOSOME BREAKAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; MALE; METHYLNITROSOUREA; MICE; MICE, INBRED BALB C; MICRONUCLEUS TESTS; MUTAGENS; TIME FACTORS;

EID: 0033151418     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(99)00082-2     Document Type: Article

References (23)

1. D. Jenssen, C. Ramel, Dose response at low doses of X- Irradiation and MMS on the induction of micronuclei in mouse erythroblasts, Mutat. Res. 41 (1976) 311-320.
2. R.C. Chaubey, K.P. George, K. Sundaram, X-ray-induced micronuclei in the bone marrow erythrocytes of mice, Int. J. Radiat. Biol. 33 (1978) 507-510.
3. P. Morales-Ramírez, T. Vallarino-Kelly, J. Mercader- Martínez, R. Rodríguez-Reyes, Induction of micronuclei by acute and chronic exposure in vivo to gamma rays in murine polychromatic erythrocytes, Mutat. Res. 341 (1994) 47-55.
4. 137Cs at very low dose rates, Int. J. Radiat. Biol. 67 (1995) 29-36.
5. K.H. Mavournin, D.H. Blakey, M.C. Cimino, M.F. Salomone, J.A. Heddle, The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency, Gene-Tox Program, Mutat. Res. 239 (1990) 29-80.
6. P. Morales-Ramfírez, T. Vallarino-Kelly, R. Rodríguez-Reyes, Effect of chlorophyllin on gamma ray induced micronuclei in polychromatic erythrocytes of murine peripheral blood determined by the ABC strategy. Mutat. Res. 367 (1995) 51-56.
7. P. Morales-Ramfírez, T. Vallarino-Kelly, G. Anguiano- Orozco, R. Rodríguez.-Reyes, Pharmacokinetics parameters of genotoxic activity inferred from the comparison of the kinetics of MN-PCE induced by chemical agents and ionizing radiation, Mutat. Res. 391 (1997) 127-134.
8. P. Morales-Ramirez, T. Vallarino-Kelly, Pharmacokinetic parameters determined from the clastogenic activity of ethylnitrosourea and dimethylnitrosamine in mice in vivo, Mutat. Res. 412 (1998) 315-322.
9. C.L. Bean, S.M. Galloway, Evaluation of the need for a late harvest time in the assay for chromosome aberrations in Chinese hamster ovary cells. Mutat. Res. 292 (1993) 3-16.
10. M.J. Armstrong, S.M. Galloway, Mismatch repair provokes chromosome aberrations in hamster cells treated with methylating agents or 6-thioguanine, but not with ethylating agents, Mutat. Res. 373 (1997) 167-178.
11. W. Schmid, The micronucleus, Mutat. Res. 31 (1975) 9-15.
12. M. Hayashi, Difference between i.p. and oral gavage application in the MN test, Mutat. Res. 223 (1989) 329-344.
13. E.G. Brain, L.J. Yu, K. Gustafsson, P. Drewes, D.J. Waxman, Modulation pf P-450-dependent ifosfamide pharmacokinetics: A better understanding of drug activation in vivo, Br. J. Cancer 77 (1998) 1768-1776.
14. J.I. Penny, F.C. Campbell, Active transport of benzo[a]pyrene in apical membrane vesicles from normal human intestinal epithelium, Biochim. Biophys. Acta 1226 (1994) 232-236.
15. A. Atkinson, D. Roy, In vivo DNA adduct formation by bisphenol A, Environ. Mol. Mutagen. 26 (1995) 60-66.
16. M.T. Mendiola-Cruz, P. Morales-Ramírez, Repair kinetics of gamma-ray induced DNA damage determined by the single cell gel electrophoresis assay in murine leucocytes in vivo, Mutat. Res. (1998) Accepted.
17. H. Inoue, K. Sugita, T. Furukawa, Long-term time-lapse cinemicrography of human erythroblasts under compression and without compression-direct measurements of generation time of each maturation stage, Int. J. Hematol. 58 (1993) 1-8.
18. S.P. Xue, S.F. Zhang, Q. Du, H. Sun, J. Xin, S.Q. Lui, J. Ma, Cell Mol. Biol. 43 (1997) 851-860.
19. G. Krishna, J. Nath, M. Petersen, T. Ong, A comparison of baseline and cyclophosphamide-induced sister chromatid exchanges in bone marrow and spleen cells of mouse and Chinese hamster cells, Environ. Mutagen. 8 (1986) 449-459.
20. G. Krishna, J. Nath, T. Ong, Mitomycin C-induced sister chromatid exchanges in vivo and in vivo/in vitro in mice and Chinese hamster, Environ. Mutagen. 10 (1987) 157-167.
21. S. Squires, A.J. Ryan, H.L. Strutt, P.J. Smith, R.T. Johnson, Deoxyguanosine enhances the cytotoxicity of the topoisomerase I inhibitor camtothecin by reducing the repair of double-strand breaks induced in replicating DNA, J. Cell Sci. 100 (1991) 883-893.
22. T.S. Zwanenburg, L.H. Mullenders, A.T. Natarajan, A.A. Zeeland, DNA lesions, chromosomal aberrations and G2 delay in CHO cells cultured in medium containing bromo- or chloro-deoxyuridine, Mutat. Res. 127 (1984) 155-168.
23. D.T. Beranek, Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents. Mutat. Res. 231 (1990) 11-30.