Differential involvement of small G proteins in Alzheimer's disease

International Journal of Molecular Medicine

Volumn 3, Issue 6, 1999, Pages 597-600

  Shimohama, Shun ^a,b   Kamiya, Shinji ^a,b   Niguchi, Takashita ^b   Sumida, Yasuo ^a   Fujimoto, Sadaki ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Alzheimer's disease; Rab; Ral; Rap; Ras; Small G protein

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; RAB PROTEIN; RAB8A PROTEIN, HUMAN; RAL PROTEIN; RALA PROTEIN, HUMAN; RALB PROTEIN, XENOPUS; RAP PROTEIN; RAS PROTEIN; XENOPUS PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN; CELL MEMBRANE; CYTOSOL; HUMAN; METABOLISM; POLYACRYLAMIDE GEL ELECTROPHORESIS; WESTERN BLOTTING;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BLOTTING, WESTERN; BRAIN; CELL MEMBRANE; CYTOSOL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; HUMANS; RAB GTP-BINDING PROTEINS; RAB1 GTP-BINDING PROTEINS; RAB3 GTP-BINDING PROTEINS; RAB5 GTP-BINDING PROTEINS; RAL GTP-BINDING PROTEINS; RAP GTP-BINDING PROTEINS; RAS PROTEINS; XENOPUS PROTEINS;

EID: 0033145902     PISSN: 11073756     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijmm.3.6.597     Document Type: Article

References (34)

1. Katzman R: Alzheimer's disease. N End J Mcd 314: 964-973, 1986.
2. Masliah E, Terry RD, Alford M, DcTeresa R and Hansen LA: Cortical and subcortical patterns of synaptophysin-likc immuno-rcactivity in Alzhcimcr's disease. Am J Pathol 138: 235-246, 1991.
3. Terry RD, Masliah E, Salmon DP, Butters N, DeTcresa R, Hill R, Hansen LA and Katzman R: Physical basis of cognitive alterations in Alzhcimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30: 572-580, 1991.
4. Boguski MS and McCormick F: Proteins regulating Ras and its relatives. Nature 366: 643-654, 1993.
5. Rittinger K, Walker PA, Eccleston JF, Nurmahomcd K, Owen D, Laue E, Gamblin SJ and Smerdon SJ: Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP. Nature 388: 693-697, 1997.
6. Gibbs JB and Marshall MS: The ras oncogene - an important regulatory clement in lower eucaryotic organisms. Microbiol Rev 53: 171-185, 19S9.
7. Bollag G and McCormick F: Regulators and effectors of ras proteins. Annu Rev Cell Biol 7: 601-632, 1991.
8. McCormick F: Ras-related proteins in signal transduction and growth control. Mol Reprod Dev 42: 500-506, 1995.
9. Zhang K, Noda M, Vass WC, Papageorgc AG and Lowy DR: Identification of small clusters of divergent amino acids that mediate the opposing effects of ras and krev-1. Science 249: 162-165, 1990.
10. Kaibuchi K, Mizuno T, Fujioka H, Yamamoto T, Kishi K, Fukumoto Y, Hori Y and Takai Y: Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-likc small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein. Mol Cell Biol 11: 2873-2880, 1991.
11. Rubinfeld B, Muncmitsu S, Clark R, Conroy L, Watt K, Crosier WJ, McCormick F and Polakis P: Molecular cloning of a GTPase activating protein specific for the krev-1 protein p21rapl. Cell 65: 1033-1042, 1991.
12. Pizon V, Chardin P, Lerosey I, Olofsson B and Tavitian A: Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region. Oncogenc 3: 201-204, 1988.
13. Olofsson B, Chardin P, Touchot N, Zahraoui A and Tavitian A: Expression of the ras-relatcd ralA, rho12 and rab genes in adult mouse tissues. Oncogenc 3: 231-234, 1988.
14. Polakis PG, Weber RF, Nevins B, Didsbury JR, Evans T and Snyderman R: Identification of the rail and racl gene products, low molecular mass GTP-binding proteins from human platelets. J Biol Chem 264: 16383-16389, 1989.
15. Wildey GM, Viggeswarapu M, Rim S and Denker: Isolation of cDNA clones and tissue expression of rat ral A and ral B GTP-bindins proteins. Biochem Biophys Res Commun 194: 552-559, 1993.
16. Chardin P and Tavitian A: Codins sequences of human ra1A and ra1B cDNAs. Nucleic Acids Res 17: 4380, 1989.
17. Zheng JY, Koda T, Fujiwara T, Kishi M, Ikehara Y and Kakinuma M: A novel Rab GTPase, Rab33B, is ubiquitously expressed and localized to the medial Golai cisternae. J Cell Sci 111:1061-1069, 1998.
18. Mirra SS, Heyman A, Mckcel D, Sumi SM, Grain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G and Berg L: The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzhcimcr's disease. Neurology 41: 479-486, 1991.
19. Brambilla R, Gnesutta N, Minichiello L, White G, Roylance AJ, Herron CE, Ramsey M, Wolfcr DP, Ccstari V, Rossi-Arnaud C, Grant SG, Chapman PF, Lipp HP and Sturani E: A role for the Ras signalling pathway in synaptic transmission and long-term memory. Nature 390: 281-286, 1997.
20. Kim JH, Liao D, Lau LF and Huganir RL: SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. Neuron 20: 683-691, 1998.
21. Ebadi M, Bashir RM, Heidrick ML, Hamada FM, Refaey HE, Hamed A, Helal G, Baxi MD, Cerutis DR and Lassi NK: Ncurotrophins and their receptors in nerve injury and repair. Neurochem Int 30: 347-374, 1997.
22. Gartner U, Holzer M, Heumann R and Arendt T: Induction of p21ras in Alzheimcr patholoey. Neuroreport 6: 1441-1444, 1995.
23. Pizon V, Desjardins M, Bucci C, Parton RG and Zerial M: Association of Rapla and Raplb proteins with late endocytic/phasocytic compartments and Rap2a with the Golgi complex. J Cell Sci 107: 1661-1670, 1994.
24. Janoueix-Lerosey I, Pashcva E, de-Tand MF, Tavitian A and de-Gunzburg J: Identification of a specific effector of the small GTP-binding protein Rap2. Eur J Biochem 252: 290-298, 1998.
25. 2+-dcpendent pathway. Curr Biol 8: 839-842, 1998.
26. Fisher von Mollard G, Stahl B, Li C, Sudhof TC and Jahn R: Rab proteins in regulated exocytosis. Trends Biochem Sci 19: 164-168, 1994.
27. Ayala J, Olofsson B, Touchot N, Zahraoui A, Tavitian A and Prochiantz A: Developmental and regional expression of three new members of the ras-gene family in the mouse brain. J Neurosci Res 22: 384-389, 1989.
28. Geppert M, Bolshakov VY, Siegelbaum SA, Takei K, De-Camilli P, Hammer RE and Sudhof TC: The role of Rab3A in neurotransmitter release. Nature 369:493-497, 1994.
29. Stettler O, Nothias F, Tavitian B and Vernier P: Double in situ hybridization reveals overlapping neuronal populations expressing the low molecular weight GTPases Rab3a and Rab3b in rat brain. Eur J Neurosci 7: 702-713, 1995.
30. Horiguchi H, Giner A, Hoflack B and Zerial M: A GDP/GTP exchange-stimulatory activity for the Rab5-RabGDI complex on clathrin-coated vesicles from bovine brain. J Biol Chem 270: 11257-11262, 1995.
31. Huber LA, de Hoop MJ, Dupree P, Zerial M, Simons K and Dotti C: Protein transport to the dendritic plasma membrane of cultured neurons is regulated by rab8P. J Cell Biol 123: 47-55, 1993.
32. Huber LA, Dupree P and Dotti CG: A deficiency of the small GTPase rabS inhibits membrane traffic in developing neurons. Mol Cell Biol 15:918-924, 1995.
33. Peranen J, Auvinen P, Virta H, Wepf R and Simons K: RabS promotes polarized membrane transport through reorganization of actin and microtubules in fibroblasts. J Cell Biol 135: 153-167, 1996.
34. Ihara Y: Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease. Brain Res 459: 138-144, 1988.