Application of LC-NMR to the identification of bulk drug impurities in GART inhibitor AG2034

Magnetic Resonance in Chemistry

Volumn 37, Issue 6, 1999, Pages 393-400

  Potts, Barbara C M ^a   Albizati, Kim F ^a   Johnson, Mark O'Neil ^b   Prosser James, Joyce ^b  

^a AGOURON PHARMACEUTICALS INC   (United States)

^b Bruker Instruments   (United States)

Author keywords

13C NMR; 1H NMR; Bulk drug impurity; LC NMR; NMR; Pyrimidothiazine

Indexed keywords

IMPURITIES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

13C NMR; 1H NMR; BULK DRUG IMPURITY; BULK DRUGS; DRUG IMPURITIES; GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE; IMPURITIES IN; LIQUID CHROMATOGRAPHY-NMR; NMR-SPECTROSCOPY; PYRIMIDOTHIAZINE;

LIQUID CHROMATOGRAPHY;

EID: 0033137365     PISSN: 07491581     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-458X(199906)37:6<393::AID-MRC468>3.0.CO;2-Q     Document Type: Article

References (10)

1. 1. Federal Register 61(3), 372 (1996).
2. 2. J. C. Lindon, J. K. Nicholson and I. D. Wilson, Prog. Nucl. Magn. Reson. Spectrosc. 29, 1 (1996).
3. 3. N. Mistry, I. M. Ismail, M. S. Smith, J. K. Nicholson and J. C. Lindon, J. Pharm. Biomed. Anal. 16, 697 (1997).
4. 4. K. Albert, J. Chromatogr. A 703, 123 (1995).
5. 5. M. D. Varney, C. L. Palmer, W. H. Romines, T. Boritzki, S. A. Margosiak, R. Almassy, C. A. Janson, C. Bartlett, E. J. Howland and R. Ferre, J. Med. Chem. 40, 2502 (1997).
6. 6. L. Braunschweiler and R. R. Ernst, J. Magn. Reson. 53, 521 (1983).
7. 7. U. Piantini, O. W. Sorensen, and R. R. Ernst, J. Am. Chem. Soc. 104, 6800 (1982).
8. 8. L. Muller, J. Am. Chem. Soc. 101, 4481 (1979).
9. 9. A. Bax and M. F. Summers, J. Am. Chem. Soc. 108, 2093 (1986).
10. 10. A. Bax and D. G. Davis, J. Magn. Reson. 65, 355 (1985).