Protein structure-based design, synthesis, and biological evaluation of 5-thia-2,6-diamino-4(3H)-oxopyrimidines: Potent inhibitors of glycinamide ribonucleotide transformylase with potent cell growth inhibition

Journal of Medicinal Chemistry

Volumn 40, Issue 16, 1997, Pages 2502-2524

  Varney, Michael D ^a   Palmer, Cindy L ^a   Romines III, William H ^a   Boritzki, Theodore ^a   Margosiak, Stephen A ^a   Almassy, Robert ^a   Janson, Cheryl A ^a   Bartlett, Charlotte ^a   Howland, Eleanor J ^a   Ferre, Rosanne ^a  

^a AGOURON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 BROMO 2,6 DIAMINO 4(3H) PYRIMIDINONE; 5 THIAPYRIMIDINONE; ANTINEOPLASTIC AGENT; FOLATE BINDING PROTEIN; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL GROWTH; CRYSTAL STRUCTURE; DIASTEREOISOMER; GROWTH INHIBITION; NONHUMAN; PROTEIN STRUCTURE; PURINE METABOLISM; PURINE SYNTHESIS; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

ACYLTRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ESCHERICHIA COLI; FOLIC ACID; HUMANS; HYDROXYMETHYL AND FORMYL TRANSFERASES; MICE; MODELS, MOLECULAR; PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; PROTEIN CONFORMATION; PYRIMIDINES; RECOMBINANT PROTEINS; STEREOISOMERISM; TUMOR CELLS, CULTURED;

EID: 15144340856     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9607459     Document Type: Article

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