Ca2+/calmodulin-dependent protein kinase II inhibitor KN-62 inhibits adrenal medullary chromaffin cell functions independent of its action on the kinase

Journal of Neurochemistry

Volumn 66, Issue 6, 1996, Pages 2517-2522

  Tsutsui, Masato ^a   Yanagihara, Nobuyuki ^a   Fukunaga, Kohji ^b   Minami, Kouichiro ^a   Nakashima, Yasuhide ^a   Kuroiwa, Akio ^a   Miyamoto, Eishichi ^b   Izumi, Futoshi ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Adrenal medulla; Ca2+ calmodulin dependent protein kinase II; Catecholamine secretion; Inhibition; Ion channels; KN 62

Indexed keywords

BOVINAE; ANIMALIA;

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; ACETYLCHOLINE; ADRENALIN; CALCIUM 45; CARBACHOL; CATECHOLAMINE; CYCLIC GMP; N [1 [4 (5 ISOQUINOLINESULFONYL) ALPHA METHYLBENZYL] 2 (4 PHENYL 1 PIPERAZINYL)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NORADRENALIN; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE INHIBITOR; SODIUM 22; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; VERATRIDINE;

ADRENALIN RELEASE; ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CATECHOLAMINE RELEASE; CELL MEMBRANE; CHROMAFFIN CELL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ION TRANSPORT; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; SODIUM TRANSPORT;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ADOLESCENT; ADRENAL MEDULLA; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; CARBACHOL; CATECHOLAMINES; CATTLE; CHROMAFFIN SYSTEM; ENZYME INHIBITORS; HUMANS; ION CHANNELS; ISOQUINOLINES; NICOTINIC AGONISTS; PIPERAZINES; SODIUM; TYROSINE 3-MONOOXYGENASE;

EID: 0029901446     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.66062517.x     Document Type: Article

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