Brain concentrations of kynurenic acid after a systemic neuroprotective dose in the gerbil model of global ischemia

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 23, Issue 4, 1999, Pages 741-752

  Salvati, Patricia ^a   Ukmar, Giorgio ^a   Dho, Luciano ^a   Rosa, Bruno ^a   Cini, Massimo ^a   Marconi, Marina ^a   Molinari, Antonio ^a   Post, Claes ^a  

^a PFIZER INC   (United States)

Author keywords

Gerbil; Ischemia; Kynurenic acid; Neuroprotection

Indexed keywords

AMINO ACID RECEPTOR BLOCKING AGENT; GLUTAMATE RECEPTOR; KYNURENIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN PROTECTION; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BRAIN LEVEL; FOREBRAIN; GERBIL; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NERVE CELL NECROSIS; NONHUMAN;

ANIMALS; BODY TEMPERATURE; BRAIN; GERBILLINAE; HIPPOCAMPUS; ISCHEMIC ATTACK, TRANSIENT; KYNURENIC ACID; MALE; NEURONS; NEUROPROTECTIVE AGENTS; PROSENCEPHALON; REPERFUSION; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 0033136456     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(99)00032-9     Document Type: Article

References (30)

1. Andine P., Lehmann A., Ellrén K., E. Wennberg, Kjellmer I., Nielsen T. and Hagberg H. (1988) The excitatory amino acid antagonist kynurenic acid administered after hypoxic-ischemia in neonatal rats offers neuroprotection. Neurosci. Lett. 90: 208-212
2. Beninger R.J., Jhamandas K., Boegman R.J. and El-Defrawy S.R. (1986) Kynurenic acid-induced protection of neurochemical and behavioural deficits produced by quinolinic acid injections into the nucleus basalis of rats. Neurosci Lett. 68: 317-321.
3. Buchan A., Li H. and Pulsinelli W.A. (1991) The N-methyl-D-aspartate antagonist, MK-801, fails to protect against neuronal damage caused by transient, severe forebrain ischemia in adult rats. J. Neurosci. 11: 1049-1056.
4. Buchan A.M., Lesiuk H., Barnes K.A., Li H., Huang Z.G., Smith K.E. and Xue D. (1993) AMPA antagonists: Do they hold more promise for clinical stroke trials than NMDA antagonists? Stroke 24:I-148 - I-152.
5. Busto R., Dietrich W.D.,. Globus M.Y.-T, Valdés I., Scheinberg P. and Ginsberg M.D. (1987) Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J. Cereb. Blood Flow Metab. 7: 729-738.
6. Colburne F. and Corbett D. (1995) Delayed postischemic hypothermia: A six month survival study using behavioral and histological assessments of neuroprotection. J. Neurosci. 15: 7250-7260.
7. Dietrich W.D., Busto R., Alonso O., Globus M.Y.-T. and Ginsberg M.D. (1993) Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats. J. Cereb. Blood Flow Metab. 13: 541-549.
8. Germano I.M., Pitts L.H., Meldrum B.S., Bartkowski H.M. and Simon R.P. (1987) Kynurenate inhibition of cell excitation decreases stroke size and deficits. Ann. Neurol. 22: 730-734.
9. Gill R. and Woodruff G.N. (1990) The neuroprotective actions of kynurenic acid and MK-801 in gerbils are synergistic and not related to hypothermia. Eur. J. Pharmacol. 176: 143-149.
10. Hicks R.R., Smith D.H., Gennarelli T.A. and McIntosh T. (1994) Kynurenate is neuroprotective following experimental brain injury in the rat. Brain Res. 655: 91-96.
11. Hicks R.R., Smith D.H. and McIntosh T.K. (1995) Temporal response and effects of excitatory amino acid antagonism on microtubule-associated protein 2 immunoreactivity following experimental brain injury in rats. Brain Res. 678: 151-160.
12. 3H] MDL 105,519, a radiolabelled antagonist for the N-methyl-D-aspartate-associated glycine site, to pig cortical brain membranes. Neurosci. Lett. 226: 79-82.
13. Kusumoto M., Arai H., Mori K. and Sato K. (1995) Resistance to cerebral ischemia in developing gerbils. J. Cereb. Blood Flow Metab. 15: 886-891.
14. Leeson P.D., Baker R., Carling R.W., Curtis N.R., Moore K.W., Williams B.J., Foster A.C., Donald A.E., Kemp J.A. and Marshall G.R. (1991) Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor. J. Med. Chem. 34: 1243-1252.
15. Lipton S.A. and Rosenberg P.A. (1994) Excitatory amino acids as a final common pathway for neurologic disorders. New Engl. J. Med. 330: 613-622.
16. Meldrum B. (1990) Protection against ischaemic neuronal damage by drugs acting on excitatory neurotransmission. Cerebrovasc. Brain Metab. Rev. 2: 27-57.
17. Miranda A.F., Boegman R.J., Beninger R.J. and Jhamandas K. (1997) Protection against quinolinic acid-mediated excitotoxicity in nigrostriatal dopaminergic neurons by endogenous kynurenic acid. Neuroscience 78: 967-975.
18. Pellegrini-Giampietro D.E., Cozzi A. and Moroni F. (1994) The glycine antagonist and free radical scavenger 7-Cl-thio-kynurenate reduces CA1 ischemic damage in the gerbil. Neuroscience 63: 701-709.
19. Plaitakis A., Fesdjian C.O. and Shashidharan P. (1996) Glutamate antagonists in amyotrophic lateral sclerosis. A review of their therapeutic potential. CNS Drugs 5: 437-456.
20. Rothman Schonfeld, A. and Glick S.D. (1979) Cerebrovascular abnormalities associated with seizure susceptibility in the mongolian gerbil. Brain Res. 173: 147-151.
21. Salvati P., Speciale C., Cini M., Marconi M., Dho L., Rosa B., Ferrario R. and Post C.(1997) Measurement of brain levels of KYNA after neuroprotective doses in the gerbil model of global ischemia. Society for Neuroscience 23: 2311.
22. Sheardown M.J., Suzdak P.D. and Nordholm L. (1993) AMPA, but not NMDA, receptor antagonism is neuroprotective in gerbil global ischaemia, even when delayed 24h. Eur. J. Pharmacol. 236: 347-353.
23. Simon R.P., Young R.S.K., Stout S. and Cheng J. (1986) Inhibition of excitatory neurotransmission with kynurenate reduces brain edema in neonatal anoxia. Neurosci. Lett. 71: 361-364.
24. Sonsalla P.K., Riordan D.E. and Heikkila R.E. (1991) Competitive and noncompetitive antagonists at N-methyl-D-aspartate receptors protect against nethamphetamine-induced dopaminergic damage in mice. J. Pharmacol. Exp. Ther. 256: 506-512.
25. 2 balance in the basal ganglia and its relevance to Parkinson's disease Synapse 19: 264-293.
26. Stone T.W. (1993) Neuropharmacology of quinolinic and kynurenic acids. Pharmacol. Rev. 45: 309-379.
27. Swartz K.J., Matson W.R., MacGarvey U., Ryan E.A. and Beal M.F. (1990) Measurement of kynurenic acid in mammalian brain extracts and cerebrospinal fluid by high-performence liquid chromatography with fluorimetric detection and coulometric electrode array detection Anal. Biochem. 185: 363-376.
28. Takaoka S., Bart R.D., Pearlstain R., Brinkhous A. and Warner D.S. (1997) Neuroprotective effect of NMDA receptor glycine recognition site antagonism persists when brain temperature is controlled. J. Cereb. Blood Flow Metab. 17: 161-167.
29. Verberne A.J.M., Widdop R.E., MacCarrone C., Jarrott B., Beart P.M. and Louis W.J. (1990) Intrathecal kynurenate reduces arterial pressure, heart rate and baroreceptor-heart rate reflex in conscious rats. Neurosci. Lett. 114: 309-315.
30. Whetsell W.O. and Shapira N.A. (1993) Biology of disease. Neuroexcitation, excitotoxicity and human neurological disease. Lab. Invest. 68: 372-387.