Discontinuation of treatment with IFN-β leads to exacerbation of experimental autoimmune encephalomyelitis in Lewis rats. Rapid reversal of the antiproliferative activity of IFN-β and excessive expansion of autoreactive T cells as disease promoting mechanisms

Journal of Neuroimmunology

Volumn 84, Issue 1, 1998, Pages 14-23

  Van Der Meide, Peter H ^a   De Labie, Miranda C D C ^a   Ruuls, Sigrid R ^b   Groenestein, Reno J ^a   Botman, Carolien A D ^a   Olsson, Tomas ^c   Dijkstra, Christine D ^b  

^a BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

ELIS POT; Experimental autoimmune encephalomyelitis; IFN ; Lewis rats

Indexed keywords

RECOMBINANT BETA INTERFERON;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ARTICLE; DOSE RESPONSE; IMMUNOTHERAPY; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE ACTIVATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; INTERFERON-BETA; LYMPH NODES; MULTIPLE SCLEROSIS; RATS; RATS, INBRED LEW; RECURRENCE; SPLEEN;

EID: 0032053599     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(97)00207-5     Document Type: Article

References (35)

1. Abreu S.L. Suppression of experimental allergic encephalomyelitis by interferon. Immunol. Commun. 11:1982;1-7.
2. Abreu S.L. Interferon in experimental autoimmune encephalomyelitis (EAE): Effects of exogenous interferon on the antigen-enhanced adoptive transfer of EAE. Int. Arch. Allergy Appl. Immun. 76:1985;302-307.
3. Adorini L., Sinigaglia F. Pathogenesis and immunotherapy of autoimmune diseases. Immunol. Today. 18:1997;209-211.
4. Andersen O., Lygner P.E., Bergstrom T., Andersson M., Vahlne A. Viral infections trigger multiple sclerosis relapses: A prospective seroepidemiological study. J. Neurol. 240:1993;417-422.
5. Barna B.P., Chou S.M., Jacobs B., Yen-Lieberman B., Ransohoff R.M. Interferon-beta impairs induction of HLA-DR antigen expression in cultured adult human astrocytes. J. Neuroimmunol. 23:1989;45-53.
6. Borden E.C., Hogan T.F., Voelkel J.G. Comparative antiproliferative activity in vitro of natural interferons alpha and beta for diploid and transformed human cells. Cancer Res. 42:1982;4948-4953.
7. Dijkstra C.D., Döpp E.A., Joling P., Kraal G. The heterogeneity of mononuclear phagocytes in lymphoid organs: Distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3. Immunology. 54:1985;589-597.
8. Gresser I., Guy-Grand D., Maury C., Maunoury M.-T. Interferon induces peripheral lymphadenopathy in mice. J. Immunol. 127:1981;1569-1575.
9. Issazadeh S., Mustafa M., Ljungdahl Å., Höjeberg B., Dagerlind Å., Elde R., Olsson T. Interferon-γ, interleukin-4 and transforming growth factor β in experimental autoimmune encephalomyelitis in Lewis rats: Dynamics of cellular mRNA expression in the central nervous system and lymphoid cells. J. Neurosci. Res. 40:1995;579-590.
10. Kimchi A., Shure H., Revel M. Regulation of lymphocyte mitogenesis by (2′-5′) oligo-isoadenylate. Nature. 282:1979;849-851.
11. + T cells in recovery from antigen-induced autoimmune disease. J. Exp. Med. 178:1993;909-916.
12. Ling P.D., Warren M.K., Vogel S.N. Antagonistic effect of interferon-beta on the interferon-gamma-induced expression of Ia antigen in murine macrophages. J. Immunol. 135:1985;1857-1863.
13. Male D., Pryce G., Hughes C., Lantos P. Lymphocyte migration into brain modelled in vitro: Control by lymphocyte activation, cytokines and antigen. Cell. Immunol. 127:1990;1-11.
14. Matsumoto Y., Hara N., Tanaka R., Fujiwara M. Immunohistochemical analysis of the rat central nervous system during experimental allergic encephalomyelitis with special reference to Ia-positive cells with dendritic morphology. J. Immunol. 136:1986;3668-3676.
15. McFarlin D.E., Blank S.E., Kibler R.F., McKneally S., Shapira R. EAE in the rat: Response to encephalitogenic proteins and peptides. Science. 179:1977;478-482.
16. Milanese C., Salmaggi A., La Mantia L., Campi A., Eoli M., Savoiardo M., Bianchi G., Nespolo A. Double blind study of intrathecal beta interferon in multiple sclerosis: Clinical and laboratory results. J. Neurol. Neurosurg. Psychiatry. 53:1990;554-557.
17. Multiple Sclerosis Collaborative Research Group (MSCRG), Jacobs L.D., Cookfair D.L., Rudick R.A., Herndon R.M., Richert J.R., Salazar A.M., Fischer J.S., Goodkin D.E.et al. Intramuscular Interferon beta-1a for disease progression in relapsing multiple sclerosis. Ann. Neurol. 39:1996;285-294.
18. Mustafa M.I., Diener P., Höjeberg D., Van der Meide P.H., Olsson T. T cell immunity and interferon-γ secretion during experimental allergic encephalomyelitis in Lewis rats. J. Neuroimmunol. 31:1991;165-177.
19. Olsson T., Kelic S., Edlund C., Bakhiet M., Höjeberg B., Van der Meide P.H., Ljungdahl Å., Kristensson K. Neuronal interferon-γ immunoreactive molecule: Bioactivities and purification. Eur. J. Immunol. 24:1994;308-314.
20. Panitch H.S., Folus J.S., Johnson K.P. Beta interferon prevents HLA class II antigen induction by gamma interferon in MS (abstract). Neurology. 39 (Suppl. 1):1989;171.
21. Raine S.C., Lee S.C., Scheinberg L.C., Duyvestein A.M., Cross A.H. Adhesion molecules on endothelial cells in the central nervous system: An emerging area in the neuroimmunology of multiple sclerosis. Clin. Immunol. Immunopathol. 52:1990;173-187.
22. Rudick R.A., Carpenter C.S., Cookfair D.L., Tuohy V.K., Ransohoff R.M. In vitro and in vivo inhibition of mitogen-driven T cell activation by recombinant interferon beta. Neurology. 43:1993;2080-2087.
23. Ruuls S.R., De Labie M.C.D.C., Weber K.S., Botman C.A.D., Groenestein R.J., Dijkstra C.D., Olsson T., Van der Meide P.H. The length of treatment determines whether IFN-β prevents or aggravates experimental autoimmune encephalomyelitis in Lewis rats. J. Immunol. 157:1996;5721-5731.
24. Sibley W.A., Bamford C.R., Clark K. Clinical viral infections and multiple sclerosis. Lancet. I:1985;1313-1315.
25. Soilu-Hänninen M., Salmi A., Salonen R. Interferon-β downregulates expression of VLA-4 antigen and antagonizes interferon-γ-induced expression of HLA-DQ on human peripheral blood monocytes. J. Neuroimmunol. 60:1995;99-106.
26. Stone L.A., Frank J.A., Albert P.S., Bash C., Smith M.E., Maloni H., McFarland H.F. The effect of interferon-β on blood-brain barrier disruptions demonstrated by contrast-enhanced magnetic resonance imaging in relapsing-remitting multiple sclerosis. Ann. Neurol. 37:1995;611-619.
27. The interferon-β Multiple Sclerosis Study Group Interferon beta-IB is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology. 43:1993;655-661.
28. The UBC MS/MRI Study Group and the Interferon-β Multiple Sclerosis Study Group, Paty D.W., Li D.K.B. Interferon beta-IB is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology. 43:1993;662-667.
29. Van der Meide P.H., De Labie M.C.D.C., Botman C.A.D., Van Bennekom W.P., Olsson T., Aten J., Weening J.J. Mercuric chloride downregulates T cell interferon-γ production in Brown Norway but not in Lewis rats; role of glutathione. Eur. J. Immunol. 23:1993;675-681.
30. Van der Meide P.H., Joosten A.M., Hermans P., Kloosterman T.C., Olsson T., De Labie M.C.D.C. Assessment of the inhibitory effect of immunosuppressive agents on rat T cell interferon-γ production using an ELISPOT assay. J. Immunol. Methods. 144:1991;203-213.
31. Vandenbark A.A., Offner H., Reshef T., Fritz R., Jen Chou C.-H., Cohen I.R. Specificity of T-lymphocyte lines for peptides of myelin basic protein. J. Immunol. 135:1985;229-233.
32. Weinstock-Guttman B., Ransohoff R.M., Kinkel R.P., Rudick R.A. The interferons: Biological effects, mechanisms of action, and use in multiple sclerosis. Ann. Neurol. 37:1995;7-15.
33. Yednock T.A., Cannon C., Fritz L.C., Sanchez-Madrid F., Steinman L., Karin N. Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin. Nature. 356:1992;63-66.
34. Yu M., Nishiyama A., Trapp B.D., Tuohy V.K. Interferon-β inhibits progression of relapsing-remitting experimental autoimmune encephalomyelitis. J. Neuroimmunol. 64:1996;91-100.
35. + T cells are essential to induce experimental autoimmune myasthenia gravis. J. Exp. Med. 184:1996;349-356.