Age-related metabolite changes and volume loss in the hippocampus by magnetic resonance spectroscopy and imaging

Neurobiology of Aging

Volumn 20, Issue 3, 1999, Pages 279-285

  Schuff, Norbert ^a,b   Amend, Diane L ^a   Knowlton, Robert ^d   Norman, David ^b   Fein, George ^a,b   Weiner, Michael W ^a,b,c  

^a SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SWEDISH MEDICAL CENTER   (United States)

Author keywords

Aging; Atrophy; Hippocampus; Magnetic resonance imaging; Magnetic resonance spectroscopy; N acetyl aspartate; Neuron loss

Indexed keywords

N ACETYLASPARTIC ACID;

ADULT; AGED; AGING; AMINO ACID BRAIN LEVEL; ARTICLE; BRAIN ATROPHY; BRAIN SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; HUMAN; MALE; NERVE DEGENERATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ADULT; AGED; AGED, 80 AND OVER; AGING; ASPARTIC ACID; ATROPHY; CHOLINE; CREATINE; FEMALE; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; PROTONS; REGRESSION ANALYSIS;

EID: 0033133368     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(99)00022-6     Document Type: Article

References (38)

1. Arnold D.L., Wolinsky J.S., Matthews P.M., Falini A. The use of magnetic resonance spectroscopy in the evaluation of the natural history of multiple sclerosis. J Neurol Neurosurg Psychiatry. 64:(suppl. 1):1998;S94-S101.
2. Birken D.L., Oldendorf W.H. N-acetyl-L-aspartic acid a literature review of a compound prominent in 1H-NMR spectroscopic studies of brain . Neurosci Biobehav Rev. 13:(1):1989;23-31.
3. Cendes F., Andermann F., Dubeau F., Matthews P.M., Arnold D.L. Normalization of neuronal metabolic dysfunction after surgery for temporal lobe epilepsy. Evidence from proton MR spectroscopic imaging. Neurology. 49:(6):1997;1525-1533.
4. Chang L., Ernst T., Poland R.E., Jenden D.J. In vivo proton magnetic resonance spectroscopy of the normal aging human brain. Life Sci. 58:(22):1996;2049-2056.
5. Charles C., Lazeyras F., Rama Krishnan R., et al. Proton spectroscopy of human brain effects of age and sex . Prog Neuropsychopharmacol Biol Psychiatry Vol. 18:1994;995-1004.
6. David J.P., Ghozali F., Fallet-Bianco C., et al. Glial reaction in the hippocampal formation is highly correlated with aging in human brain. Neurosci Lett. 235:(1-2):1997;53-56.
7. De Stefano N., Matthews P.M., Arnold D.L. Reversible decreases in N-acetylaspartate after acute brain injury. Magn Reson Med. 34:(5):1995;721-727.
8. Ende G.R., Laxer K.D., Knowlton R.C., et al. Temporal lobe epilepsy bilateral hippocampal metabolite changes revealed at proton MR spectroscopic imaging . Radiology. 202:(3):1997;809-817.
9. Fukuzako H., Hashiguchi T., Sakamoto T., et al. Metabolite changes with age measured by proton magnetic resonance spectroscopy in normal subjects. Psychiatry Clin Neurosci. 51:1997;261-263.
10. Hetherington H.P., Pan J.W., Mason G.F., et al. Quantitative 1H spectroscopic imaging of human brain at 4.1 T using image segmentation. Magn Reson Med. 36:(1):1996;21-29.
11. Hugg J.W., Kuzniecky R.I., Gilliam F.G., Morawetz R.B., Fraught R.E., Hetherington H.P. Normalization of contralateral metabolic function following temporal lobectomy demonstrated by 1H magnetic resonance spectroscopic imaging. Ann Neurol. 40:(2):1996;236-239.
12. Jack C.R. Jr, Petersen R.C., Xu Y.C., et al. Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease. Neurology. 49:(3):1997;786-794.
13. Jack C.R. Jr, Twomey C.K., Zinsmeister A.R., Sharbrough F.W., Petersen R.C., Cascino G.D. Anterior temporal lobes and hippocampal formations normative volumetric measurements from MR images in young adults . Radiology. 172:(2):1989;549-554.
14. Jack C.R. Jr, Petersen R.C., Xu Y., et al. Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease. Neurology. 51:(4):1998;993-999.
15. Kalra S., Cashman N.R., Genge A., Arnold D.L. Recovery of N-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy. Neuroreport 1. 9:(8):1998;1757-1761.
16. Keefover R.W. Aging and cognition. Neurol Clin. 16:(3):1998;635-648.
17. Laakso M.P., Soininen H., Partanen K., et al. MRI of the hippocampus in Alzheimer's disease sensitivity, specificity, and analysis of the incorrectly classified subjects . Neurobiol Aging. 19:(1):1998;23-31.
18. Lim K.O., Zipursky R.B., Murphy G.M. Jr, Pfefferbaum A. In vivo quantification of the limbic system using MRI effects of normal aging . Psychiatry Res. 35:(1):1990;15-26.
19. Lim K.O., Spielman D.M. Estimating NAA in cortical gray matter with applications for measuring changes due to aging. Magn Reson Med. 37:(3):1997;372-377.
20. MacKay S., Ezekiel F., Di Sclafani V., et al. Alzheimer disease and subcortical ischemic vascular dementia evaluation by combining MR imaging segmentation and H-1 MR spectroscopic imaging . Radiology. 198:(2):1996;537-545.
21. Maudsley A.A., Lin E., Weiner M.W. Spectroscopic imaging display and analysis. Magn Reson Imaging. 10:1992;471-485.
22. Maudsley A.A., Matson G.B., Hugg J.W., Weiner M.W. Reduced phase encoding in spectroscopic imaging. Magn Reson Med. 31:(6):1994;645-645.
23. Milner B. Disorders of learning and memory after temporal lobe lesions in man. Clin Neurosurg. 19:1972;421-446.
24. Moffett J.R., Namboodiri M.A., Cangro C.B., Neale J.H. Immunohistochemical localization of N-acetylaspartate in rat brain. Neuroreport. 2:(3):1991;131-134.
25. Morrison J.H., Hof P.R. Life and death of neurons in the aging brain. Science 17. 278:(5337):1997;412-419.
26. Nadel L. The hippocampus and space revisited. Hippocampus. 1:1991;221-229.
27. Reiman E.M., Uecker A., Caselli R.J., et al. Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's disease. Ann Neurol. 44:(2):1998;288-291.
28. Schuff N., Marmar C.R., Weiss D.S., et al. Reduced hippocampal volume and N-acetyle aspartate in post traumatic stress disorder. Ann NY Acad Sci. 821:1997;516-520.
29. Schuff N., Amend D., Ezekiel F., et al. Changes of hippocampal N-acetyl aspartate and volume in Alzheimer's disease. A proton MR spectroscopic imaging and MRI study. Neurology. 49:(6):1997;1513-1521.
30. Schuff N., Amend D.L., Meyerhoff D.J., et al. Alzheimer disease quantitative H-1 MR spectroscopic imaging of frontoparietal brain . Radiology. 207:(1):1998;91-102.
31. Squire L.R., Zola-Morgan S. The medial temporal lobe memory system. Science. 253:(5026):1991;1380-1386.
32. Sullivan E.V., Marsh L., Mathalon D.H., Lim K.O., Pfefferbaum A. Age-related decline in MRI volumes of temporal lobe gray matter but not hippocampus. Neurobiol Aging. 16:(4):1995;591-606.
33. Sullivan E.V., Marsh L., Mathalon D.H., Lim K.O., Pfefferbaum A. Anterior hippocampal volume deficits in nonamnesic, aging chronic alcoholics. Alcohol Clin Exp Res Exp. 19:(1):1995;110-122.
34. Tohgi H., Takahashi S., Kato E., et al. Reduced size of right hippocampus in 39- to 80-year-old normal subjects carrying the apolipoprotein E epsilon4 allele. Neurosci Lett. 236:(1):1997;21-24.
35. Urenjak J., Williams S.R., Gadian D.G., Noble M. Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J Neurosci. 13:(3):1993;981-989.
36. Vermathen P., Ende G., Laxer K.D., Knowlton R.C., Matson G.B., Weiner M.W. Hippocampal N-acetylaspartate in neocortical epilepsy and mesial temporal lobe epilepsy. Ann Neurol. 42:(2):1997;194-199.
37. Watson C., Andermann F., Gloor P., et al. Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging. Neurology. 42:(9):1992;1743-1750.
38. West M.J. Regionally specific loss of neurons in the aging human hippocampus. Neurobiol Aging. 14:(4):1993;287-293.