Enhanced efficiency of lactosylated poly-L-lysine-mediated gene transfer into cystic fibrosis airway epithelial cells

American Journal of Respiratory Cell and Molecular Biology

Volumn 20, Issue 5, 1999, Pages 1081-1086

  Kollen, Wouter J W ^b   Schembri, Frank M ^b   Gerwig, Gerrit J ^b   Vliegenthart, Johannes F G ^b   Glick, Mary Catherine ^b   Scanlin, Thomas F ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; GLYCEROL; LACTOSE; LUCIFERASE; POLYLYSINE;

AMINO ACID SEQUENCE; ARTICLE; CELL LINE; CHEMISTRY; CYSTIC FIBROSIS; DRUG EFFECT; GENE EXPRESSION REGULATION; GENE TRANSFER; GENE VECTOR; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; NOSE MUCOSA; PATHOLOGY;

AMINO ACID SEQUENCE; CELL LINE, TRANSFORMED; CHLOROQUINE; CYSTIC FIBROSIS; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GLYCEROL; HUMANS; LACTOSE; LUCIFERASES; MOLECULAR SEQUENCE DATA; NASAL MUCOSA; POLYLYSINE;

EID: 0033124961     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.20.5.3417     Document Type: Article

References (24)

1. Curiel, D. T., J. M. Pilewski, and S. M. Albelda. 1905. Gene therapy approaches for inherited and acquired lung diseases. Am. J. Respir. Cell Mol. Biol. 14:1-18.
2. Verma, I. M., and N. Somia. 1997. Gene therapy - promises, problems and prospects. Nature 389:239-242.
3. Cheng, S. H., and R. K. Scheule. 1998. Airway delivery of cationic lipid: DNA complexes for cyslic fibrosis. Adv. Drug Del. Rev. 30:173-184.
4. Crystal, R. G. 1995. Transfer of genes to humans: early lessons and obstacles to success. Science 270:404-410.
5. Anderson, W. F. 1998. Human gene therapy. Nature 392:25-30.
6. Kollen, W. J. W., P. Midoux, P. Erbacher, A. Yip, A. C. Roche, M. Monsigny, M. C. Glick, and T. F. Scanlin. 1996. Gluconoylated and glycosylated polylysines as vectors for gene transfer into cystic fibrosis airway epithelial cells. Hum. Gene Ther. 7:1577-1586.
7. Di Stefano, G., C. Busi, A. Mattioli, and L. Fiume. 1995. Selective delivery to the liver of antiviral nucleoside analogs coupled to a high molecular mass lactosaminated poly-L-lysine and administered in mice by intramuscular route. Biochem. Pharm. 49:1769-1775.
8. Fiume, L., G. Di Stefano, C. Busi, A. Mattioli, G. B. Gervasi, M. Bertini, C. Bartoli, R. Catalani, G. Caccia, C. Farina, A. Fissi, O. Pieroni, R. Giuseppetti, E. D'Ugo, R. Bruni, and M. Rapicetta. 1997. Hepatotropic conjugate of adenine monophosphate with lactosaminated poly-L-lysine. J. Hepatol. 26:253-259.
9. Hard, K., G. van Zadelhoff, P. Moonen, J. P. Kamerling, and J. F. G. Vliegenthart. 1992. The Asn-linked carbohydrate chains of human Tamm-Horsfall glycoprotein of one male: novel sulfated and novel N-acetylgalactosamine-containing N-linked carbohydrate chains. Eur. J. Biochem. 209: 895-915.
10. 1H-nuclear magnetic resonance spectroscopy as a tool in the structural analysis of carbohydrates related to glycoproteins. Adv. Carbohydr. Chem. Biochem 41-209-374.
11. Jetten, A. M., J. R. Yankaskas, M. J. Stutts, N. J. Willumsen, and R. C. Boucher. 1989. Persistence of abnormal chloride conductance regulation in transformed cystic fibrosis epithelia. Science 244:1472-1475.
12. Olsen, J. C., L. G. Johnson, M. J. Stutts, B. Sarkadi, J. R. Yankaskas, R. Swanstrom, and R. C. Boucher. 1992. Correction of the apical membrane chloride permeability defect in polarized cystic fibrosis airway epithelia following retroviral-mediated gene transfer. Hum. Gene Ther. 3:253-266.
13. Reddel, R. R., Y. Ke, B. I. Gerwin, M. G. McMcnamin, J. F. Lechner, R. T. Su, D. E. Brash, J. B. Park, J. S. Rhim, and C. C. Harris. 1988. Transformation of human bronchial epithelial cells by infection with SV-40 or adenovirus - SV40 12 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes. Cancer Res. 48:1904-1909.
14. Pfeifer, A. M. A., G. E. Mark, L. Malan-Shibley, S. Graziano, P. Amstad, and C. C. Harris. 1989. Cooperation of C-raf-1 and C-myc protooncogenes in the neoplastic transformation of simian virus 40 large tumor antigen-immortalized human bronchial epithelial cells. Proc. Natl. Acad. Sci. USA 86:10075-10079.
15. Brasier, A. R., J. E. Tate, and J. F. Habener. 1989. Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines. Biotechniques 7:1116-1122.
16. Lowry, O., N. Rosebrough, A. Farr, and R. Randall. 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:265-275.
17. Midoux, P., C. Mendes, A. Legrand, J. Raimond, R. Mayer, M. Monsigny, and A. C. Roche. 1993. Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells. Nucleic Acids Res 21:871-878.
18. Midoux, P., R. Mayer, and M. Monsigny. 1995. Membrane permeabilization by α-helical peptides: a flow cytometry study. Biochim. Biophys. Acta 1239: 249-256.
19. Murata, M., Y. Sugahara, S. Takashashi, and S. I. Ohnishi. 1987. pII-dependent membrane fusion activity of a synthetic twenty amino acid peptide with the same sequence as that of the hydrophobic segment of influenza virus hemagglutinin. J. Biochem. 102:957-962.
20. Zauner, W., A. Kichler, W. Schmidt, K. Mechtler, and F. Wagner. 1997. Glycerol and polylysine synergize in their ability to rupture vesicular membranes: a mechanism for increased transferrin-polylysine-mediated gene transfer. Exp. Cell Res. 232:137-145.
21. Wolfert, M. A., and L. W. Seymour. 1998. Chloroquine and amphipathic peptide helices show synergistic transfection in vitro. Gene Ther 5:409-414.
22. Erbacher, P., A. C. Roche, M. Monsigny, and P. Midoux. 1996. Putative role of chloroquine in gene transfer into a human hepatoma cell line by DNA/ lactosylated polylysine complexes. Exp. Cell Res. 225:186-194.
23. Sato, S., C. L. Wardt, M. E. Krouse, J. F. Wine, and R. R. Kopito. 1996. Glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation. J. Biol. Chem. 271:635-638.
24. Wüthrich, K. 1986. NMR of Proteins and Nucleic Acids. Chapter 2. John Wiley & Sons, New York. 17.