Role of a novel KCa opener in regulating K+ channels of hypoxic human pulmonary vascular cells

American Journal of Respiratory Cell and Molecular Biology

Volumn 20, Issue 4, 1999, Pages 737-745

  Peng, Wei ^a   Hoidal, John R ^a   Farrukh, Imad S ^a  

^a UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUSTELA PUTORIUS FURO;

4 AMINOPYRIDINE; 8 (4 CHLOROPHENYLTHIO)GUANOSINE 3',5' CYCLIC MONOPHOSPHOROTHIOATE; 8-(4-CHLOROPHENYLTHIO)GUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE; ADENOSINE 3',5' PHOSPHOROTHIOATE; ADENOSINE-3',5'-CYCLIC PHOSPHOROTHIOATE; CHARYBDOTOXIN; CYCLIC AMP; CYCLIC GMP; DRUG DERIVATIVE; EGTAZIC ACID; ENZYME INHIBITOR; INWARDLY RECTIFYING POTASSIUM CHANNEL; NUCLEOTIDE; POTASSIUM CHANNEL; POTASSIUM CHANNEL PROTEIN I(SK); PRASTERONE; PROTEIN KINASE INHIBITOR; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; CELL CULTURE; CELL HYPOXIA; CELL MEMBRANE POTENTIAL; DRUG EFFECT; HUMAN; LUNG CIRCULATION; PATCH CLAMP; PHYSIOLOGY; VASCULAR SMOOTH MUSCLE;

4-AMINOPYRIDINE; CELL HYPOXIA; CELLS, CULTURED; CHARYBDOTOXIN; CYCLIC AMP; CYCLIC GMP; DEHYDROEPIANDROSTERONE; EGTAZIC ACID; ENZYME INHIBITORS; HUMANS; MEMBRANE POTENTIALS; MUSCLE, SMOOTH, VASCULAR; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN KINASE INHIBITORS; PULMONARY CIRCULATION; THIONUCLEOTIDES;

EID: 0033113514     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.20.4.3390     Document Type: Article

References (28)

1. 2+-dependent action potentials in small pulmonary arteries of the cat. J. Appl. Physiol. 59:1389-1393.
2. Post, J. M., J. R. Hume, S. L. Archer, and E. K. Weir. 1992. Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction. Am. J. Physiol. 262(Cell. Physiol. 31):C882-C890.
3. Yuan, X.-J., W. F. Goldman, M. L. Tod, L. J. Rubin, and M. P. Blaustein. 1993. Hypoxia reduces potassium currents in cultured rat pulmonary but not mesenteric arterial myocytes. Am. J. Physiol. 264:L116-L123.
4. + channels: regulation in human pulmonary vascular smooth muscle cells. Am. J. Physiol. 272(Cell. Physiol. 41):C1271-C1278.
5. Brayden, J. E., and M. T. Nelson. 1992. Regulation of arterial tone by activation of calcium-dependent potassium channels. Science 256:532-535.
6. Peng, W., S. V. Karwande, J. R. Hoidal, and I. S. Farrukh. 1996. Potassium currents in cultured human pulmonary arterial smooth muscle cells. J. Appl. Physiol. 80:1187-1196.
7. Clapp, L. H., and A. M. Gurney. 1992. ATP-sensitive channels regulate the resting potential of pulmonary arterial smooth muscle cells. Am. J. Physiol. 262:H916-H920.
8. + channels in cerebral artery smooth muscle cells. Am. J. Physiol. (Cell. Physiol. 34): C299-C303.
9. + channels in human pulmonary arterial smooth muscle cells: role of nitric oxide. J. Appl. Physiol. 81:1264-1272.
10. Castle, N. A., D. J. Haylett, and D. H. Jenkinson. 1989. Toxins in the characterization of potassium channels. Trends Pharmacol. Sci. 12:59-65.
11. Barrett-Connor, E., and D. Goodman-Guruen. 1995. The epidemiology of DHEAS and cardiovascular disease. ANYAS 774:259-270.
12. Herrington, D. M. 1995. Dehydroepiandrosterone and coronary atherosclerosis. ANYAS 774:271-280.
13. Jesse, R. L., K. Loesser, D. M. Eich, Y. Z. Qian, M. L. Hess, and J. E. Nestler. 1995. Dehydroepiandrosterone inhibits human platelet aggregation in vitro and in vivo. ANYAS 774:281-290.
14. Jones, A. W., and R. G. Hart. 1975. Altered ion transport in aortic smooth muscle during deoxycorticostcrone acetate hypertension in the rat. Circ. Res. 37:333-341.
15. Beynon, H. L. C., N. D. Garbett, and P. J. Barnes. 1988. Severe premenstrual exacerbation of asthma: effect of intramuscular progesterone. Lancet 2:370-372.
16. +-channel opener. Am. J. Physiol. 214(Lung Cell. Mol. Physiol. 18):L186-L195.
17. Hamill, O. P., A. Marty, E. Neher, B. Sakmann, and F. J. Sigworth. 1981. Improved patch-clamp recording from cells and cell-free membrane patches. Pfluegers Arch. 391:85-100.
18. Fabiato, A. 1988. Computer programs for calculating total from specified free or free from specified total ionic concentrations in aqueous solutions containing multiple metals and ligands. Methods Enzymol. 157:378-417.
19. Song, Y., and J. M. Simard. 1995. Beta-adrenoreceptor stimulation activates large-conductance Ca-activated K channels in smooth muscle cells from basilar artery of guinea pig. Pflugers Arch. 430:984-993.
20. Bennie, R. E., C. S. Packer, D. R. Powell, N. Jin, and R. A. Rhoades. 1991. Biphasic contractile response of pulmonary artery to hypoxia. Am. J. Physiol. 261:L156-L163.
21. Rodman, D. M., T. Yamaguchi, K. Hasunuma, R. F. O'Brien, and I. F. McMurtry. 1990. Effects of hypoxia on endothelium-dependent relaxation of rat pulmonary artery. Am. J. Physiol. 258:L207-L214.
22. Kovitz, K. L., T. D. Aleskowitch, T. J. Sylvester, and N. A. Flavahan. 1993. Endothelium-derived contracting and relaxing factors contributing to hypoxic responses of pulmonary arteries. Am. J. Physiol. 265:H1139-H1148.
23. Farrukh, I. S., and J. R. Michael. 1992. Cellular mechanisms that control pulmonary vascular tone during hypoxia and normoxia. Am. Rev. Respir. Dis. 145:1389-1397.
24. Nossaman, B. D., A. D. Kaye, C. J. Feng, and P. J. Kadowitz. 1997. Effects of charybdotoxin on responses to nitrovasodilators and hypoxia in the rat lung. Am. J. Physiol. 212(Lung Cell. Mol. Physiol. 16):L787-L791.
25. Cornfield, D. N., H. L. Reeve, S. Tolarova, E. K. Weir, and S. Archer. 1996. Oxygen causes fetal pulmonary vasodilation through activation of a calcium-dependent potassium channel. Proc. Natl. Acad. Sci. USA 93:8089-8094.
26. McCobb, D. P., N. L. Fowler, T. Featherstone, C. J. Lingle, M. Saito, J. E. Krause, and L. Salkoff. 1995. A human calcium-activated potassium channel gene expressed in vascular smooth muscle. Am. J. Physiol. 269(Heart Circ. Physiol. 38):H767-H777.
27. McManus, O. B., G. H. Harris, K. M. Giangiacomo, P. Feigenbaum, J. P. Reuben, M. E. Addy, J. F. Burka, C. J. Kaczorowski, and M. L. Garcia. 1993. An activator of calcium-dependent potassium channels isolated from a medicinal herb. Biochemistry 32:6128-6133.
28. Michel, A., F. Laurent, J. Bompart, K. Hadj-Kaddour, J. P. Chapat, M. Boucard, and P. A. Bonnet. 1993. Cardiovascular effects of SCA40, a novel potassium channel opener, in rats. Br. J. Pharmacol. 110:1031-1036.